| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C421109-1ml |
1ml |
现货  |
|
| 别名 | 环索奈德 | (11β,16α)-16,17-[[(R--环己基亚甲基)双(氧基)]-11-羟基-21-(2-甲基-1-氧代丙氧基)pregna-1,4-二烯-3,20 -二酮 | 环索奈德 |
|---|---|
| 英文别名 | Alvesco 160 | Ciclesonida | CICLESONIDE [EP MONOGRAPH] | SCHEMBL3688 | E83CFZ7SZD | Omnaris HFA | UNII-S59502J185 | CCG-269962 | (11?,16?)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione | C3701 | |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Ciclesonide |
| 生化机理 | 糖皮质激素治疗哮喘的前药的主要成分；在肺中去酯化为活性代谢物。消炎药。通过靶向病毒NSP-15（EC90 =6.3μM），还可以阻止SARS-CoV-2在体外Vero细胞中复制。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 糖皮质激素受体激动剂 |
| 产品介绍 |
Ciclesonide (RPR251526) 是一种具有强效抗炎活性的糖皮质激素，可用于哮喘研究。 |
| ALogP | 5.3 |
|---|
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | [2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate |
| INCHI | InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1 |
| InChi Key | LUKZNWIVRBCLON-GXOBDPJESA-N |
| Canonical SMILES | CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6 |
| Isomeric SMILES | CC(C)C(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)O[C@H](O2)C6CCCCC6 |
| 分子量 | 540.7 |
| Reaxy-Rn | 37811599 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811599&ln= |
| 分子量 | 540.700 g/mol |
|---|---|
| XLogP3 | 5.300 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 540.309 Da |
| 单同位素质量Monoisotopic Mass | 540.309 Da |
| 拓扑极表面积Topological Polar Surface Area | 99.100 Ų |
| 重原子数Heavy Atom Count | 39 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1100.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 9 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H373: 通过长时间或反复暴露对器官造成损害 H413: 可能对水生生物造成长期的有害影响 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。 |
| Reaxy-Rn | 37811599 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811599&ln= |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Xiao Li, Jia Chen, Caixia Yan, Xuanwei Li, Yaokun Xia, Qingwei Zhao. (2024) Alkanediol–hexafluoroisopropanol amphiphilic supramolecular solvent: Fabrication, characterization, and application potential for doping control of hormones and metabolic modulators in human urine. MICROCHEMICAL JOURNAL, 201 (110533). [10.1016/j.microc.2024.110533] |
| 1. Xiao Li, Jia Chen, Caixia Yan, Xuanwei Li, Yaokun Xia, Qingwei Zhao. (2024) Alkanediol–hexafluoroisopropanol amphiphilic supramolecular solvent: Fabrication, characterization, and application potential for doping control of hormones and metabolic modulators in human urine. MICROCHEMICAL JOURNAL, 201 (110533). [10.1016/j.microc.2024.110533] |
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