Glucocorticoids (GCs) are steroid hormones synthesized and secreted by the adrenal cortex. Their release is regulated by the hypothalamic–pituitary–adrenal (HPA) axis and follows a pronounced circadian rhythm.
Glucocorticoids (GCs) are a class of steroid hormones synthesized in the adrenal cortex from cholesterol, produced mainly in the zona fasciculata. In humans, the predominant endogenous glucocorticoid is cortisol (with corticosterone usually lower), whereas in rats/mice corticosterone is the main ...