| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C424327-1ml |
1ml |
现货  |
|
| 别名 | 皮质酮 |
|---|---|
| 英文别名 | (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | A | HMS3713G06 | (11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione | Corticosterone, 1mg/ml in Methanol | NCGC0026090 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Corticosterone |
| 生化机理 | 皮质酮是一种为应对压力而合成的激素。它能结合并激活 MCRs（矿质皮质激素受体）和 GRs（糖皮质激素受体），从而改变其表达。这最终会影响膜的离子传导。皮质酮诱导小鼠骨髓凋亡。强效内源性糖皮质激素和矿质类固醇受体激动剂（EC 50 = 20 nM，GR）。诱导细胞凋亡。调节体内碳水化合物、钾和钠的代谢。可渗透血脑屏障。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 糖皮质激素受体激动剂；矿物质皮质激素受体激动剂 |
| 产品介绍 |
Corticosteroid is an activator of MCR. Corticosteroid is an activator of MCR. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-019-6 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| INCHI | InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 |
| InChi Key | OMFXVFTZEKFJBZ-HJTSIMOOSA-N |
| Canonical SMILES | CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O |
| Isomeric SMILES | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O |
| WGK Germany | 3 |
| RTECS | GM7650000 |
| PubChem CID | 5753 |
| 分子量 | 346.46 |
| Beilstein号 | 2339601 |
| 比旋光度 | +221 to +226 deg(C=1, EtOH) |
|---|---|
| 熔点 | 180-183°C |
| 分子量 | 346.500 g/mol |
| XLogP3 | 1.900 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 346.214 Da |
| 单同位素质量Monoisotopic Mass | 346.214 Da |
| 拓扑极表面积Topological Polar Surface Area | 74.600 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 638.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 7 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H317: 可能引起皮肤过敏反应 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 |
| WGK Germany | 3 |
| RTECS | GM7650000 |
| Merck Index | 2538 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| 1. Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi. (2023) Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway. Frontiers in Bioscience-Landmark, 28 (11): (311). [PMID:38062826] [10.31083/j.fbl2811311] |
| 2. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2024) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, 461 (132477). [PMID:37716268] [10.1016/j.jhazmat.2023.132477] |
| 3. Junhui He, Dongbo Han, Chunlian Jia, Jiaxiu Xie, Fucui Zhu, Jie Wei, Dongmei Li, Dongmei Wei, Yi Li, Li Tang, Guining Wei, Jing Yan, Yuanming Tong, Lifang Yang, Xuecai Tan. (2023) Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression. Drug Design Development and Therapy, [PMID:36923105] [10.2147/DDDT.S399183] |
| 4. Yuan Baoshi, Shi Kexin, Zha Juanmin, Cai Yujia, Gu Yue, Huang Kai, Yue Wenchang, Zhai Qiaocheng, Ding Ning, Ren Wenyan, He Weiqi, Xu Ying, Wang Tao. (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death & Disease, 14 (1): (1-12). [PMID:36681687] [10.1038/s41419-022-05545-7] |
| 5. Jun Huang, Bin Chen, Hao Wang, Sheng Hu, Xudong Yu, James Reilly, Zhiming He, Yong You, Xinhua Shu. (2022) Dihydromyricetin Attenuates Depressive-like Behaviors in Mice by Inhibiting the AGE-RAGE Signaling Pathway. Cells, 11 (23): (3730). [PMID:36496991] [10.3390/cells11233730] |
| 6. He Junhui, Li Dongmei, Wei Jie, Wang Sheng, Chu Shifeng, Zhang Zhao, He Fei, Wei Dongmei, Li Yi, Xie Jiaxiu, Lai Kedao, Chen Naihong, Wei Guining. (2022) Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. NEUROCHEMICAL RESEARCH, 47 (12): (3761-3776). [PMID:36222958] [10.1007/s11064-022-03761-3] |
| 7. Li Sheng, Wang Zhi, Yao Jing Wen, Jiao Hong Chao, Wang Xiao Juan, Lin Hai, Zhao Jing Peng. (2022) Reduced PGC-1β protein expression may underlie corticosterone inhibition of mitochondrial biogenesis and oxidative phosphorylation in chicken muscles. Frontiers in Physiology, 13 [PMID:36311241] [10.3389/fphys.2022.989547] |
| 8. Sun Jia-Yi, Liu Yi-Tong, Jiang Sheng-Nan, Guo Peng-Mei, Wu Xin-Yu, Yu Jia. (2022) Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway. Frontiers in Pharmacology, 13 [PMID:36188568] [10.3389/fphar.2022.999712] |
| 9. Mingfa Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Haifang Li, Yunlei Zhou, Hai Lin. (2022) Research Note: Creatine monohydrate alleviates protein breakdown induced by corticosterone via inhibiting ubiquitin proteasome pathway in chicken myotubes. POULTRY SCIENCE, 101 (102177). [PMID:36194918] [10.1016/j.psj.2022.102177] |
| 10. Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao, Luan Shu. (2022) Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling. NUTRITIONAL NEUROSCIENCE, [PMID:36039913] [10.1080/1028415X.2022.2112439] |
| 11. Wang Yan, Zhou Sixu, Song Xujiao, Ding Shanshan, Wang Baogui, Wen Jiangfeng, Chen Chunlin. (2022) Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway. NEUROCHEMICAL RESEARCH, 47 (10): (3126-3136). [PMID:35804209] [10.1007/s11064-022-03668-z] |
| 12. Chai Yuhui, Cai Yawen, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway. Frontiers in Pharmacology, 13 [PMID:35496273] [10.3389/fphar.2022.812362] |
| 13. Jie Liu, Yi Cheng, Yuanjin Zhang, Shengbo Huang, Zongjun Liu, Xin Wang. (2021) Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats. TOXICOLOGY LETTERS, 352 (46). [PMID:34600097] [10.1016/j.toxlet.2021.09.010] |
| 14. Huina Li, Kefan Wu, Yue Zhang, Ning Li, Kaijin Wang. (2020) Crassifoside H ameliorates depressant behavior in chronic unpredictable mild stress rats by improving HPA axis dysfunction and inhibiting inflammation in hippocampus. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 19 (8): (1693-1699). [10.4314/tjpr.v19i8.18] |
| 15. Lan Zhang, Yue Yang, Lei Di, Jun-long Li, Ning Li. (2020) Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. PHARMACEUTICAL BIOLOGY, 58 (1): (498-509). [PMID:32476554] [10.1080/13880209.2020.1765812] |
| 16. Jingjing Liu, Ning Xu, Hong Men, Shuang Li, Yanli Lu, Sze Shin Low, Xin Li, Lihang Zhu, Chen Cheng, Gang Xu, Qingjun Liu. (2020) Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System. SENSORS, 20 (5): (1422). [PMID:32150916] [10.3390/s20051422] |
| 17. Zhang Yingyi, Li Liang, Wang Qi, Shen Mei, Han Weili, Yang Xuemei, Chen Lingyun, Ma Ande, Zhou Zhengzheng. (2019) Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (15): (3361-3372). [PMID:31119349] [10.1007/s00216-019-01810-5] |
| 18. Li-Tao Yi, Rong-Hao Mu, Shu-Qi Dong, Shuang-Shuang Wang, Cheng-Fu Li, Di Geng, Qing Liu. (2018) miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice. JOURNAL OF PSYCHOPHARMACOLOGY, [PMID:29484897] [10.1177/0269881118758304] |
| 19. He Xiaolie, Yang Li, Wang Mei, Zhuang Xizhen, Huang Ruiqi, Zhu Rongrong, Wang Shilong. (2017) Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and Dexanabinol-Loaded Solid Lipid Nanoparticles. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 42 (6): (2281-2294). [PMID:28848078] [10.1159/000480001] |
| 20. Mei Yang, Youning Ma, Wenjun Gui, Yiping Ren, Guonian Zhu, Yihua Liu. (2015) Determination of 26 endocrine disrupting chemicals in fish and water using modified QuEChERS combined with solid-phase extraction and UHPLC-MS/MS. Analytical Methods, 7 (19): (8418-8431). [10.1039/C5AY01082A] |
| 21. Zhijing Song,Huanyu Gao,Wenchun Xie,Qing Sun,Kai Liang,Yan Li. (2020-12-29) Quantitative MALDI-MS assay of steroid hormones in plasma based on hydroxylamine derivatization.. Analytical biochemistry, 616 (114089-114089). [PMID:33359147] |
| 22. Ang W, Chen G, Xiong L, Chang Y, Pi W, Liu Y, Li C, Zheng J, Zhou L, Yang B, Deng Y, Yang S, Luo Y, Wei Y.. (2014) Synthesis and biological evaluation of novel naphthalene compounds as potential antidepressant agents.. Eur J Med Chem, 82 (263-273). [PMID:24915002] [10.1016/j.ejmech.2014.05.061] |
| 1. Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi. (2023) Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway. Frontiers in Bioscience-Landmark, 28 (11): (311). [PMID:38062826] [10.31083/j.fbl2811311] |
| 2. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2024) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, 461 (132477). [PMID:37716268] [10.1016/j.jhazmat.2023.132477] |
| 3. Junhui He, Dongbo Han, Chunlian Jia, Jiaxiu Xie, Fucui Zhu, Jie Wei, Dongmei Li, Dongmei Wei, Yi Li, Li Tang, Guining Wei, Jing Yan, Yuanming Tong, Lifang Yang, Xuecai Tan. (2023) Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression. Drug Design Development and Therapy, [PMID:36923105] [10.2147/DDDT.S399183] |
| 4. Yuan Baoshi, Shi Kexin, Zha Juanmin, Cai Yujia, Gu Yue, Huang Kai, Yue Wenchang, Zhai Qiaocheng, Ding Ning, Ren Wenyan, He Weiqi, Xu Ying, Wang Tao. (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death & Disease, 14 (1): (1-12). [PMID:36681687] [10.1038/s41419-022-05545-7] |
| 5. Jun Huang, Bin Chen, Hao Wang, Sheng Hu, Xudong Yu, James Reilly, Zhiming He, Yong You, Xinhua Shu. (2022) Dihydromyricetin Attenuates Depressive-like Behaviors in Mice by Inhibiting the AGE-RAGE Signaling Pathway. Cells, 11 (23): (3730). [PMID:36496991] [10.3390/cells11233730] |
| 6. He Junhui, Li Dongmei, Wei Jie, Wang Sheng, Chu Shifeng, Zhang Zhao, He Fei, Wei Dongmei, Li Yi, Xie Jiaxiu, Lai Kedao, Chen Naihong, Wei Guining. (2022) Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. NEUROCHEMICAL RESEARCH, 47 (12): (3761-3776). [PMID:36222958] [10.1007/s11064-022-03761-3] |
| 7. Li Sheng, Wang Zhi, Yao Jing Wen, Jiao Hong Chao, Wang Xiao Juan, Lin Hai, Zhao Jing Peng. (2022) Reduced PGC-1β protein expression may underlie corticosterone inhibition of mitochondrial biogenesis and oxidative phosphorylation in chicken muscles. Frontiers in Physiology, 13 [PMID:36311241] [10.3389/fphys.2022.989547] |
| 8. Sun Jia-Yi, Liu Yi-Tong, Jiang Sheng-Nan, Guo Peng-Mei, Wu Xin-Yu, Yu Jia. (2022) Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway. Frontiers in Pharmacology, 13 [PMID:36188568] [10.3389/fphar.2022.999712] |
| 9. Mingfa Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Haifang Li, Yunlei Zhou, Hai Lin. (2022) Research Note: Creatine monohydrate alleviates protein breakdown induced by corticosterone via inhibiting ubiquitin proteasome pathway in chicken myotubes. POULTRY SCIENCE, 101 (102177). [PMID:36194918] [10.1016/j.psj.2022.102177] |
| 10. Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao, Luan Shu. (2022) Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling. NUTRITIONAL NEUROSCIENCE, [PMID:36039913] [10.1080/1028415X.2022.2112439] |
| 11. Wang Yan, Zhou Sixu, Song Xujiao, Ding Shanshan, Wang Baogui, Wen Jiangfeng, Chen Chunlin. (2022) Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway. NEUROCHEMICAL RESEARCH, 47 (10): (3126-3136). [PMID:35804209] [10.1007/s11064-022-03668-z] |
| 12. Chai Yuhui, Cai Yawen, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway. Frontiers in Pharmacology, 13 [PMID:35496273] [10.3389/fphar.2022.812362] |
| 13. Jie Liu, Yi Cheng, Yuanjin Zhang, Shengbo Huang, Zongjun Liu, Xin Wang. (2021) Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats. TOXICOLOGY LETTERS, 352 (46). [PMID:34600097] [10.1016/j.toxlet.2021.09.010] |
| 14. Huina Li, Kefan Wu, Yue Zhang, Ning Li, Kaijin Wang. (2020) Crassifoside H ameliorates depressant behavior in chronic unpredictable mild stress rats by improving HPA axis dysfunction and inhibiting inflammation in hippocampus. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 19 (8): (1693-1699). [10.4314/tjpr.v19i8.18] |
| 15. Lan Zhang, Yue Yang, Lei Di, Jun-long Li, Ning Li. (2020) Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. PHARMACEUTICAL BIOLOGY, 58 (1): (498-509). [PMID:32476554] [10.1080/13880209.2020.1765812] |
| 16. Jingjing Liu, Ning Xu, Hong Men, Shuang Li, Yanli Lu, Sze Shin Low, Xin Li, Lihang Zhu, Chen Cheng, Gang Xu, Qingjun Liu. (2020) Salivary Cortisol Determination on Smartphone-Based Differential Pulse Voltammetry System. SENSORS, 20 (5): (1422). [PMID:32150916] [10.3390/s20051422] |
| 17. Zhang Yingyi, Li Liang, Wang Qi, Shen Mei, Han Weili, Yang Xuemei, Chen Lingyun, Ma Ande, Zhou Zhengzheng. (2019) Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (15): (3361-3372). [PMID:31119349] [10.1007/s00216-019-01810-5] |
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