计算溶液所需的质量、体积或浓度。
Deflazacort
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Deflazacort 是一种糖皮质激素，是一种抗炎剂和免疫抑制剂。A systemic corticosteroid.
Information
Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
In vitro
In vivo
Deflazacort results in a significant and equal decrease of thymus weight, indicating a marked reduction in total immunogenic tissue in rats. Deflazacort reduces thymus weight and Daily weight gain in rats. Deflazacort lowers liver IFG-I and GHR mRNA in rats. Deflazacort (DFC) is a heterocyclic glucocorticoid with anti-inflammatory activity but with decreased side effects. Deflazacort and [3H]dexamethasone (DEX) similarly induce in vivo ornithine decarboxylase activity in hippocampus and liver, although body weight loss after chronic treatment is significantly less for DFC. Deflazacort induces dose-dependent decreases in osteocalcin (OC) plasma production rate (PPR). Deflazacort and prednisolone increase both postabsorptive plasma glucose and plasma calcium levels in sheep, but there are no significant differences between their effects. Deflazacort, especially combined with L-arginine, spares quadriceps muscle from injury-induced regeneration (myf5 expression) compared with placebo treatment, despite an increase in membrane permeability immediately after exercise. Deflazacort alone prevents the typical progressive loss of function (measured as voluntary distance run over 24 hours) that is observed 3 months later in placebo-treated mice. Deflazacort causes a less significant alteration in the pattern of GH secretion and does not negatively affect the overall amount of GH secreted.
Cell Data
cell lines：Colon cancer cell lines DLD-1, LoVo, HCT15, and Colo205
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
别名
地夫可特
英文别名
MDL 458 | 5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11β,16β)-
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Deflazacort
生化机理
地氟沙考（MDL 458）是一种糖皮质激素，可用作抗炎药和免疫抑制剂。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
名称和识别符
EC号
238-483-7
分子类型
小分子
Isomeric SMILES
CC1=N[C@@]2([C@H](O1)C[C@@H]3[C@@]2(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)C(=O)COC(=O)C
关联CAS
MeSH Entry Terms
Calcort;deflazacort;Dezacor;Emflaza;Zamene
分子量
441.52
Reaxy-Rn
37936925
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37936925&ln=
技术文档
高级数据
产品属性
| ALogP | 2 |
|---|
安全和危险性（GHS）
象形图
信号词
Danger
危险声明
H373: 通过长时间或反复暴露对器官造成损害
H360: 可能损害生育力或未出生的孩子
H361: 怀疑破坏生育力或未出生的孩子
预防措施声明
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P203: 使用前，获取、阅读并遵守所有安全说明。
P318: 如果暴露或担心，请就医。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）