氟环素, 糖皮质激素受体激动剂

糖皮质激素受体激动剂

1篇引用文献

Moligand™

10mM in DMSO

CAS编号: 356-12-7(DMSO)
分子式: C₂₆H₃₂F₂O₇
分子量: 494.52

有货

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
F407947-1ml	1ml	现货

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Compound libraries (12332)

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基本描述

英文别名	(6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
规格或纯度	Moligand™, 10mM in DMSO
英文名称	Fluocinonide
生化机理	氟西萘德（Vanos）是一种强效糖皮质激素类固醇，局部用作治疗湿疹等皮肤病的消炎药。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	激动剂
作用机制	糖皮质激素受体激动剂
产品介绍	Fluocinonide 是有效的糖皮质激素类固醇。 Information Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. In vitro Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam. In vivo Fluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed. Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥98%

产品属性

ALogP	1.374
hba_count	6
HBD Count	1
Rotatable Bond	4

关联靶点（人）

NR3C1 Tclin 糖皮质激素受体(Glucocorticoid receptor) (3 活性数据)

点击查看靶蛋白信息： NR3C1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

分子类型	小分子
Canonical SMILES	CC(=O)OCC(=O)C12OC(C)(C)OC1CC3C4CC(F)C5=CC(=O)C=CC5(C)C4(F)C(O)CC23C
分子量	494.52
Reaxy-Rn	26095433
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26095433&ln=

化学和物理性质

DMSO(mg / mL) Max Solubility	99
DMSO(mM) Max Solubility	200.19
Water(mg / mL) Max Solubility	<1

安全和危险性（GHS）

Reaxy-Rn	26095433
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26095433&ln=

SDS英文版

技术规格说明书

Concentration(Compounding value)	9-11(mmol/L)
Record the entire process by video	Conform

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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此产品的引用文献

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1. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li. (2019) Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics. JOURNAL OF CHROMATOGRAPHY A, 1606 (460382). [PMID:31353072] [10.1016/j.chroma.2019.460382]

参考文献

1. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li. (2019) Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics. JOURNAL OF CHROMATOGRAPHY A, 1606 (460382). [PMID:31353072] [10.1016/j.chroma.2019.460382]