The Hippo pathway is an important signaling network that regulates tissue growth, cell proliferation, and tissue homeostasis. Its downstream YAP/TAZ–TEAD transcriptional module is closely associated with the initiation, progression, and treatment resistance of multiple tumors. As the ...
The Hippo signaling pathway is a cell-state sensing system centered on the MST/MAP4K-LATS kinase network, with YAP/TAZ-TEAD serving as its major transcriptional output. Unlike classical signaling pathways with fixed ligands and receptors, Hippo integrates multiple inputs, including cell contact, ...
The cytoskeleton is a dynamic fibrous network composed of microfilaments, microtubules, and intermediate filaments, mainly consisting of actin, tubulin, and different types of intermediate filament proteins. The cytoskeleton not only maintains cell morphology, cell polarity, and intracellular ...