Defensins are cysteine-rich cationic antimicrobial peptides produced primarily by neutrophils, intestinal Paneth cells, and various mucosal epithelial cells. They can directly disrupt microbial membranes, entrap pathogens, recruit immune cells, and regulate the mucosal microbiota, making them ...
The IL-22 pathway is a highly specialized cytokine pathway in barrier tissue immunity. Its distinctive feature does not lie in directly driving immune cell-mediated cytotoxicity or lymphocyte expansion, but in converting information on infection, injury, and inflammation sensed by the immune ...
With the increasing global issue of bacterial resistance and the frequent emergence of new infectious diseases, ribosomally synthesized antimicrobial peptides (RAMPs) have become a promising focus in antibiotic research. Antimicrobial peptides can be categorized into non-ribosomal peptides and ...