Neutrophils contain numerous effector proteins involved in host defense, including MPO, NE, Cathepsin G, PR3, BPI, Azurocidin, Lactoferrin, and Lysozyme. In human neutrophils, HNPs are also prominent α-defensin effectors. These proteins cooperate in pathogen clearance, whereas their persistent ...
Defensins are cysteine-rich cationic antimicrobial peptides produced primarily by neutrophils, intestinal Paneth cells, and various mucosal epithelial cells. They can directly disrupt microbial membranes, entrap pathogens, recruit immune cells, and regulate the mucosal microbiota, making them ...
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