Stable isotope-labeled compounds use ²H, ¹³C, ¹⁵N, or ¹⁸O to label metabolic substrates, allowing their transformation and fate in vivo to be identified by mass spectrometry or nuclear magnetic resonance. This technology can be used to determine substrate sources, metabolic pathways, interorgan ...
Stable isotopes can be understood as “different-weight versions” of the same element (different numbers of neutrons). They are non-radioactive and chemically very similar to the common (light) forms, but can be clearly distinguished by mass spectrometry or isotope-ratio instruments. Therefore, ...