Bone remodeling depends on the dynamic coupling between new bone formation by osteoblasts and old bone removal by osteoclasts. ALP, TRAP, Cathepsin K, and MMPs participate in the establishment of the mineralization environment, osteoclast maturation, collagen degradation, and matrix remodeling, ...
Bone metabolism is a dynamic process involving continuous coordination among bone formation, bone resorption, and mineralization, thereby maintaining the stability of bone mass, bone microarchitecture, and mechanical properties. Estrogen deficiency, long-term glucocorticoid exposure, aging, ...
The RANK signaling pathway is an important component of the TNF receptor superfamily signaling network, with a core axis composed of RANKL, RANK, and OPG.