概述规格储存与运输技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 此产品的引用文献技术文档和文章引用文献溶液计算器

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为什么选择此级别

EnzymoPure™ 级，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存。超低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 55 篇同行评审文献引用。

概述

为粘多糖的分解酶，可水解组织基质中的主要成分透明质酸，增加组织的通透性，从而促使皮下输液和局部积贮的渗出液或血液的吸收。临床可用于加速皮下、肌肉注射药液的吸收，促进局麻药的浸润，减轻注射部分疼痛，促进手术及创伤后局部水肿或血肿的消散。透明质酸酶在β-D-GalNAc-(1→4)-β-D-GlcA键处裂解透明质酸，产生3-(4-deoxy-β-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine 四糖或六糖。该酶专一作用于透明质酸，对软骨素（chondroitin）和硫酸软骨素（chondroitin sulfate）无活性。

透明质酸酶广泛存在于自然界。在人体中，它存在于不少器官和体液中。透明质酸酶见于病毒、噬菌体、真菌和细菌的分泌物。它还存在于线虫和蚂蟥的分泌物中。蛇和蝎子的毒液中会产生透明质酸酶。蜜蜂、蜘蛛、黄蜂、大黄蜂、毛虫、鱼类和蜥蜴也会分泌透明质酸酶。

应用

透明质酸酶（来自Streptomyces hyalurolyticus）已用于：制备DMEM/F-12（杜氏改良Eagle培养基/营养混合物F-12）培养基，用于从分离肿瘤组织中分离和纯化单细胞；作为消化液组分，用于从睾丸组织获得生殖干细胞。

Hyaluronidase is widely present in nature.In humans, it is present in a number of organs and body fluids. Hyaluronidase is found in the secretions of virus, bacteriophage, fungi and bacteria. It is also present in nematode and leeches secretions. Snakes and scorpions produce hyaluronidase in their venom. Hyaluronidase is also secreted by bees, spiders, wasps, hornets, caterpillars, fishes and lizards.

Application

Hyaluronidase from Streptomyces hyalurolyticus has been used:in the preparation of DMEM/F-12 (Dulbecco′s modified eagle medium/nutrient mixture F-12) media for the isolation and purification of single cells from dissociated tumour tissue；as a component of digestion solution for the derivation of germline stem cells from testicular tissue.

规格

产品名称

透明质酸酶

别名

玻璃酸酶 | 透明质酸裂解酶

英文别名

Hyaluronate Lyase

规格或纯度

EnzymoPure™, ≥ 300 IU/mg，来源于牛睾丸

生化机理

透明质酸裂解酶在β-D-GlcNAc-(1→4)-β-D-GlcA键上切割透明质酸，得到3-(4-脱氧β-D-葡萄糖-4-烯基糖基)-N-乙酰基-D-葡糖胺四糖和六糖。与其他透明质酸酶不同，该酶对透明质酸具有特异性，并且对软骨素和硫酸软骨素无活性。透明质酸酶属于内切糖苷酶，通过配合β-葡糖醛酸酶和β-N-乙酰氨基葡萄糖苷酶等外切糖苷酶完成其内切功能。透明质酸酶调节透明质酸的周转代谢。

CAS编号和信息

37259-53-3

酶学委员会编号

3.2.1.35

分子类型

酶

储存与运输

浓度

≥ 300 IU/mg，来源于牛睾丸

储存条件

-20°C储存

运输条件

超低温运输

单位定义

在37℃、pH 5.3-5.7 条件下，一个单位可导致2.0 mL反应混合物在600 nm下的％透光率变化0.330/min (45 min检测）

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

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✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

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📊 产品数据表

产品规格和应用的快速参考摘要。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到26个结果

批号(Lot Number)	证书类型	货号
A2305545	分析证书	H141272
A2305553	分析证书	H141272
J2418477	分析证书	H141272
J2418474	分析证书	H141272
I2515324	分析证书	H141272
I2515348	分析证书	H141272
I2515347	分析证书	H141272
F2327336	分析证书	H141272
A2305529	分析证书	H141272
F2327337	分析证书	H141272
J2418483	分析证书	H141272
I2406320	分析证书	H141272
I2406315	分析证书	H141272
I2406314	分析证书	H141272
I2226302	分析证书	H141272
G2229349	分析证书	H141272
F2327347	分析证书	H141272
A2305544	分析证书	H141272
A2305552	分析证书	H141272
I2226304	分析证书	H141272
I2226303	分析证书	H141272
G2229395	分析证书	H141272
G2229358	分析证书	H141272
F2201134	分析证书	H141272
F2201131	分析证书	H141272
F2201129	分析证书	H141272

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技术文档和文章

透明质酸

目录：技术文章

探索主题:

透明质酸

常见组织解离酶的原理与选择策略

目录：技术文章

探索主题:

组织解离组织解离酶

Principles and Selection Strategies for Common Tissue Dissociation Enzymes

目录：技术文章

探索主题:

Tissue dissociation Tissue dissociation enzyme

透明质酸酶：解锁生物医学领域的“魔法酶”

目录：技术文章

探索主题:

透明质酸酶

Hyaluronidase: Unlocking a “Magic Enzyme” in Biomedicine

目录：技术文章

探索主题:

Enzymes Hyaluronic acid

Hyaluronan

目录：技术文章

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此产品的引用文献

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引用文献

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4. Zhaowei Yin, Chaoren Qin, Shaowei Pan, Chen Shi, Guanfu Wu, Yan Feng, Jing Zhang, Ziyi Yu, Bin Liang, Jianchao Gui. (2023) Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis. Materials Today Bio, [PMID:37822452] [10.1016/j.mtbio.2023.100813]
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7. Qiannan Li, Yufei Wang, Qianqian Zhu, Haifang Liu, Jianbo Liu, Hong-Min Meng, Zhaohui Li. (2023) A dual-mode system based on molybdophosphoric heteropoly acid and fluorescent microspheres for the reliable and ultrasensitive detection of alkaline phosphatase. ANALYST, 148 (6): (1259-1264). [PMID:36779364] [10.1039/D2AN02052A]
8. Chen Zhang, Zhengxiang Cheng, Yuanyuan Zhou, Ziyi Yu, Hongyu Mai, Changhao Xu, Jing Zhang, Jiali Wang. (2022) The novel hyaluronic acid granular hydrogel attenuates osteoarthritis progression by inhibiting the TLR-2/NF-κB signaling pathway through suppressing cellular senescence. Bioengineering & Translational Medicine, 8 (3): (e10475). [PMID:37206234] [10.1002/btm2.10475]
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17. Hualu Lai, Xin Ding, Junxian Ye, Jie Deng, Shengmiao Cui. (2020) pH-responsive hyaluronic acid-based nanoparticles for targeted curcumin delivery and enhanced cancer therapy. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:33243547] [10.1016/j.colsurfb.2020.111455]
18. Chen Di, Shu Yang, Chen Jian, Cao Xianying. (2020) Preparation and in vitro bioactive evaluation of cashew-nut proteins hydrolysate as a potential source of anti-allergy peptides. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 58 (10): (3780-3789). [PMID:34471301] [10.1007/s13197-020-04838-z]
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20. Pirah Ayaz, Bingjie Xu, Xiansheng Zhang, Jiping Wang, Dan Yu, Jindan Wu. (2020) A pH and hyaluronidase dual-responsive multilayer-based drug delivery system for resisting bacterial infection. APPLIED SURFACE SCIENCE, [10.1016/j.apsusc.2020.146806]
21. Zhan Wenhua, Li Hanrui, Guo Yingying, Du Getao, Wu Yayan, Zhang Dexin. (2020) Construction of Biocompatible Dual-Drug Loaded Complicated Nanoparticles for in vivo Improvement of Synergistic Chemotherapy in Esophageal Cancer. Frontiers in Oncology, [PMID:32432038] [10.3389/fonc.2020.00622]
22. Chen Yunyun, Zhao Yanbao, Sun Lei, Zou Xueyan. (2019) Tri-responsive porous silica carrier with gold nanoparticles for chemophotothermal combination therapy. JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 93 (2): (332-340). [10.1007/s10971-019-05183-0]
23. Huiyan Ying, Juan Zhou, Mingyu Wang, Dandan Su, Qiaoqiao Ma, Guozhong Lv, Jinghua Chen. (2019) In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing. Materials Science & Engineering C-Materials for Biological Applications, [PMID:31029343] [10.1016/j.msec.2019.03.093]
24. Zhu Chen, Shang Deng, De-chao Yuan, Kang Liu, Xiao-cong Xiang, Liang Cheng, Dong-qin Xiao, Li Deng, Gang Feng. (2018) Novel nano-microspheres containing chitosan, hyaluronic acid, and chondroitin sulfate deliver growth and differentiation factor-5 plasmid for osteoarthritis gene therapy. Journal of Zhejiang University-SCIENCE B, [PMID:30507075] [10.1631/jzus.B1800095]
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26. Jia Nan Zhang, Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Xin Dong Guo. (2018) Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal filler for anti-ageing treatment. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, [10.1016/j.jiec.2018.05.007]
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39. Shuo Yu, Lu Zhang, Yanshen Yang, Meijuan Wang, Tingting Liu, Wenwen Ji, Yang Liu, Hao Lv, Yang Zhao, Xi Chen, Tinghua Hu. (2024) Polydopamine-Based Resveratrol-Hyaluronidase Nanomedicine Inhibited Pancreatic Cancer Cell Invasive Phenotype in Hyaluronic Acid Enrichment Tumor Sphere Model. ACS Pharmacology & Translational Science, [PMID:38633596] [10.1021/acsptsci.3c00304]
40. Xin Jin, Chengxiong Wei, Kai Li, Peinan Yin, Chengwei Wu, Wei Zhang. (2024) Polyphenol-mediated hyaluronic acid/tannic acid hydrogel with short gelation time and high adhesion strength for accelerating wound healing. CARBOHYDRATE POLYMERS, [PMID:39048222] [10.1016/j.carbpol.2024.122372]
41. Dandan Wei, Guanhua Jiao, Yinghua Tao, Liuxin Yang, Tao Liu, Fengya Jing, Tianzhu Zhang. (2025) Polypropylene Mesh Coated with Dual Cross-Linked Hyaluronic Acid/Polyvinyl Alcohol Composite Hydrogel with Antiadhesion and Angiogenesis Properties for Abdominal Wall Repair. Advanced Materials Technologies, [10.1002/admt.202401786]
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43. Chao-fan He, Tian-hong Qiao, Xu-chao Ren, Mingjun Xie, Qing Gao, Chao-qi Xie, Peng Wang, Yuan Sun, Huayong Yang, Yong He. (2025) Printability in Multi-material Projection-Based 3-Dimensional Bioprinting. Research, [PMID:40041038] [10.34133/research.0613]
44. Zhu Dan, Zhong Hanyan, Shi Jingzhan, Liu Qiang, Wang Yiping. (2025) Ratiometric surface-enhanced Raman scattering quantification of extracellular matrix metalloproteinase-2 activity for tumor diagnosis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:39966175] [10.1007/s00216-025-05792-5]
45. Yingying Chen, Dan Zhu, Hanyan Zhong, Zhixing Gan, Shenfei Zong, Zhuyuan Wang, Yiping Cui, Yiping Wang. (2024) Ultrasensitive Detection of Matrix Metalloproteinase 2 Activity Using a Ratiometric Surface-Enhanced Raman Scattering Nanosensor with a Core–Satellite Structure. ACS Applied Materials & Interfaces, [PMID:38204415] [10.1021/acsami.3c15344]
46. Qinfu Zhao, Shengyu Wang, Yang Yang, Xian Li, Donghua Di, Chungang Zhang, Tongying Jiang, Siling Wang. (2017) Hyaluronic acid and carbon dots-gated hollow mesoporous silica for redox and enzyme-triggered targeted drug delivery and bioimaging. Materials Science & Engineering C-Materials for Biological Applications, [PMID:28576012] [10.1016/j.msec.2017.04.059]
47. Shangting Du, Lingyu Li, Junhao Kou, Tianyi Zhu, Zhenyi Song, Yonghua Zhan, Daocheng Wu, Wenhua Zhan. (2025) Blackberry-Like Doxorubicin Loaded Hyaluronic Acid/Zinc Phthalocyanine Loaded Mesoporous Silica Nanocomposites for Long-Term Tumor Photodynamic and Chemotherapy Synergistic Therapy. International Journal of Nanomedicine, [PMID:40692537] [10.2147/IJN.S530041]
48. Jiancong Ni, Xiaochun Xu, Bifang Yang, Liyang Liu, Weiqiang Yang, Xiaoping Chen, Guiping Chen, Qingxiang Wang, Zhenyu Lin. (2025) Indicator-Free Detection of Hyaluronidase Based on a Conductivity-Regulated Bipolar Electrochemiluminescence Platform. ANALYTICAL CHEMISTRY, [PMID:40827572] [10.1021/acs.analchem.5c03409]
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