味苦。25℃时的溶解度（mg/ml):水0.28，乙醇15，甲醇6.2，丙酮9.3，氯仿1.6，丙二醇12.7和乙醚0.35。溶于浓硫酸呈强烈的绿色荧光。最大吸收波长242nm(E^1%_1cm445)。肾上腺皮质（the adrenal cortex）分泌的主要的糖皮质激素，它的消炎能力是皮质酮（corticosterone）的三倍。

Hydrocortisone (Cortisol) 是肾上腺皮质分泌的类固醇激素或糖皮质激素。类固醇由肾上腺皮质合成。对于蛋白质、核酸和脂质代谢的调节至关重要。在药理上，氢化可的松可用于抑制炎症反应。

Information

Hydrocortisone (NSC 10483) Hydrocortisone (NSC 10483, Cortisol) is a steroid hormone or glucocorticoid produced by the adrenal gland.
In vitro

Hydrocortisone prevents endothelial barrier breakdown in response to pro-inflammatory stimuli (TNFalpha administration) in the human brain microvascular endothelial cell line hCMEC/D3, which could be demonstrated to be partly based on maintenance of occludin levels. Hydrocortisone-treated dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibits production of IFN-gamma but induces an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces T-cell proliferation in dendritic cells. Hydrocortisone prevents TNF-alpha induced severe degradation of the glycocalyx, increased coronary resistance, heightened vascular leak and permeability to hydroxyethyl starch and caused mast-cell degranulation in isolated guinea pig hearts. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation in isolated guinea pig hearts. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as release of histamine from resident mast cells. Hydrocortisone increases the levels of IL-4-induced germ line C epsilon transcripts by twofold and delivers the signal required for transcription of mature C epsilon mRNA. Hydrocortisone induces S mu-S epsilon deletional switch recombination in IL-4-treated B cells, and support a model of sequential isotype switching from IgM to IgE via IgG4.

In vivo

Cell Data

cell lines：Platelet

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

Cortisol | (11β)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Hydrocortisone (NSC 10483)

生化机理

氢化可的松（NSC 10483，皮质醇）是一种由肾上腺分泌的类固醇激素或糖皮质激素。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

激动剂

作用机制

糖皮质激素受体激动剂；矿物质皮质激素受体激动剂

名称和识别符

EC号

200-020-1

分子类型

小分子

Isomeric SMILES

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

分子量

362.46

Beilstein号

1354819

Reaxy-Rn

2340333

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2340333&ln=

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

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批次质量数据。输入批号以获取对应 COA。

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高级数据

产品属性

ALogP	1.6

关联靶点（人）

NR3C1 Tclin 糖皮质激素受体(Glucocorticoid receptor) (2 活性数据)

点击查看靶蛋白信息： NR3C1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

SHBG Tchem 性激素结合球蛋白(Sex hormone-binding globulin) (1 活性数据)

点击查看靶蛋白信息： SHBG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NR3C2 Tclin 盐皮质激素受体(Mineralocorticoid receptor) (1 活性数据)

点击查看靶蛋白信息： NR3C2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

SERPINA6 Tchem 皮质类固醇结合球蛋白(Corticosteroid-binding globulin) (1 活性数据)

点击查看靶蛋白信息： SERPINA6

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

熔点

211-214°C

安全和危险性（GHS）

WGK Germany

RTECS

GM8925000

Merck Index

4787

个人防护装备

Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

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C of A & Other Certificates(BSE/TSE, COO):

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技术文档和文章

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