G2426588计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 提供 ≥95%(HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,充氩。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 35 篇同行评审文献引用。
规格
规格或纯度
Moligand™, ≥95%(HPLC)
英文名称
lovastatin
储存条件
-20°C储存,充氩
运输条件
超低温运输
纯度
≥95%(HPLC)
名称和识别符
EC号
692-955-0
分子类型
小分子
IUPAC Name
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
INCHI
1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
InChi Key
PCZOHLXUXFIOCF-BXMDZJJMSA-N
Smiles
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
Isomeric SMILES
CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
分子量
404.54
Reaxy-Rn
14572691
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14572691&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机杂环化合物 |
| 类（Class) | 内酯 |
| 亚类（Subclass） | δ戊内酯 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | δ戊内酯 |
| 其他上位类（Alternative Parents） | 脂肪酸酯 氧烷 二羧酸及其衍生物 仲醇 羧酸酯 氧环化合物 有机氧化物 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族杂多环化合物 |
| 取代基（Substituents） | 羟基苯甲酸酯 - 脂肪族杂多环化合物 - 羰基 - 羧酸衍生物 - 羧酸酰胺 - δ-戊酸内酯 - δ-戊酸内酯 - 二羧酸或其衍生物 - 脂肪酸酯 - 脂肪酰基 - 烃衍生物 - 有机氧化物 - 有机氧化合物 - 有机氧化合物 - 氧杂环 - 氧杂环丁烷 - 醛基 |
| 描述（Description） | 该化合物属于有机化合物中的δ-戊内酯类。这类环状有机化合物含有氧杂环丁烷-2-酮结构单元。 |
| 外部描述符（External Descriptors） | polyketide - fatty acid ester - delta-lactone - carbobicyclic compound - statin (naturally occurring) |
三维结构
交互式化学结构模型
产品属性
| ALogP | 4.3 |
|---|
关联靶点（人）
HMGCR
Tclin
3-羟基-3-甲基戊二酰辅酶A还原酶(3-hydroxy-3-methylglutaryl-coenzyme A reductase)
(23 活性数据)
NR1I2
Tchem
核受体亚家族 1 第 I 组成员 2(Nuclear receptor subfamily 1 group I member 2)
(0 活性数据)
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
ABL1
Tclin
Tyrosine-protein kinase ABL
(18331 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
FDPS
Tclin
Farnesyl diphosphate synthase
(1240 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
TSHR
Tclin
Thyroid stimulating hormone receptor
(29986 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
AVPR2
Tclin
Vasopressin V2 receptor
(2912 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
AGTR1
Tclin
Type-1 angiotensin II receptor
(5176 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
CRHR1
Tclin
Corticotropin releasing factor receptor 1
(2996 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
PPARG
Tclin
Peroxisome proliferator-activated receptor gamma
(15191 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
关联靶点（其它种属）
ERG11
Cytochrome P450 51 (617 活性数据)
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cruzipain (33337 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Ntsr1
Neurotensin receptor 1 (48 活性数据)
Pde4d
Phosphodiesterase 4D (4 活性数据)
Bdkrb1
Bradykinin B1 receptor (77 活性数据)
Ppard
Peroxisome proliferator-activated receptor delta (358 活性数据)
Abcb1b
P-glycoprotein 1 (174 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Hdac1
Histone deacetylase 1 (93 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
Fgfr3
Fibroblast growth factor receptor 3 (21 活性数据)
Hcar2
Hydroxycarboxylic acid receptor 2 (55 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Klebsiella pneumoniae (43867 活性数据)
Staphylococcus aureus (210822 活性数据)
Acinetobacter baumannii (41033 活性数据)
Escherichia coli (133304 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Leishmania infantum (5912 活性数据)
Plasmodium falciparum (966862 活性数据)
Cryptococcus neoformans (21258 活性数据)
Candida albicans (78123 活性数据)
Canis familiaris (36305 活性数据)
Oryctolagus cuniculus (11301 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
Hepatitis C virus (23859 活性数据)
Cricetinae gen. sp. (3197 活性数据)
Monkey (844 活性数据)
3T3-L1 (3664 活性数据)
MEF (1005 活性数据)
Syrian golden hamster (1610 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
BCHE
Cholinesterase (8742 活性数据)
dengue virus type 2 (2400 活性数据)
Plasma (328 活性数据)
ACAT
Acyl-CoA:cholesterol acyltransferase (1121 活性数据)
TGR
Thioredoxin glutathione reductase (28579 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Rorc
Nuclear receptor ROR-gamma (89407 活性数据)
fba
Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
敏感性
对光线敏感
比旋光度
320 ° (C=0.5, CH3CN)
熔点
175°C
分子量
404.500 g/mol
XLogP3
4.300
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
5
可旋转键计数Rotatable Bond Count
7
精确质量Exact Mass
404.256 Da
单同位素质量Monoisotopic Mass
404.256 Da
拓扑极表面积Topological Polar Surface Area
72.800 Ų
重原子数Heavy Atom Count
29
形式电荷Formal Charge
0
复杂度Complexity
666.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
8
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
信号词
危险
危险声明
H302: 吞食有害
H317: 可能引起皮肤过敏反应
H351: 怀疑引起遗传缺陷
H361: 怀疑破坏生育力或未出生的孩子
H372: 通过长时间或反复暴露对器官造成损害
预防措施声明
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P272: 被污染的工作服不允许离开工作场所
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P330: 漱口
P302+P352: 如皮肤沾染：用水充分清洗。
P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P501: 将内容物/容器处理到。。。
P203: 使用前，获取、阅读并遵守所有安全说明。
P301+P317: 如果被吞咽：请寻求医疗帮助。
P318: 如果暴露或担心，请就医。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
RTECS
EK7907000
Merck Index
5586
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
此产品的引用文献
引用文献
| 1. Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie. (2023) Alisol B regulates AMPK/mTOR/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia. PHYTOMEDICINE, [PMID:38520833] [10.1016/j.phymed.2023.155313] |
| 2. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun. (2023) Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37099836] [10.1016/j.ejmech.2023.115391] |
| 3. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang. (2023) Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways. ACS Chemical Neuroscience, [PMID:36917811] [10.1021/acschemneuro.3c00104] |
| 4. Bo Wei, Yuanfang Li, Meiying Ao, Wenxiang Shao, Kun Wang, Tong Rong, Yun Zhou, Yong Chen. (2022) Ganglioside GM3-Functionalized Reconstituted High-Density Lipoprotein (GM3-rHDL) as a Novel Nanocarrier Enhances Antiatherosclerotic Efficacy of Statins in apoE−/− C57BL/6 Mice. Pharmaceutics, 14 (11): (2534). [PMID:36432725] [10.3390/pharmaceutics14112534] |
| 5. Qing Sun, Li Li, Quan Zhou. (2022) Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats. Drug Design Development and Therapy, [PMID:35607596] [10.2147/DDDT.S364234] |
| 6. Pan Zhenzhen, Wang Kai, Wang Xiniao, Jia Zhirong, Yang Yuqi, Duan Yalei, Huang Lianzhan, Wu Zhuo-Xun, Zhang Jian-ye, Ding Xuansheng. (2022) Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer, 21 (1): (1-17). [PMID:35303882] [10.1186/s12943-022-01547-3] |
| 7. Ping-Ting Xiao, Yu-Jia Kuang, Shi-Yu Liu, Zhi-Shen Xie, Jin-Hua Hao, E-Hu Liu. (2022) The antihyperlipidemic equivalent combinatorial components from peel of Citrus reticulata ‘Chachi’. JOURNAL OF FOOD AND DRUG ANALYSIS, [PMID:35647727] [10.38212/2224-6614.3388] |
| 8. Bei Yan, Lei Chen, Yanhui Wang, Jiacheng Zhang, Hui Zhao, Qinglian Hua, Shengjie Pei, Zihang Yue, Hui Liang, Huaqi Zhang. (2022) Preventive Effect of Apple Polyphenol Extract on High-Fat Diet-Induced Hepatic Steatosis in Mice through Alleviating Endoplasmic Reticulum Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:35227062] [10.1021/acs.jafc.1c07733] |
| 9. Zhishen Xie, Er-wen Li, Gai Gao, Yueyue Du, Mengyao Wang, Hui Wang, Pan Wang, Yonghui Qiao, Yunfang Su, Jiangyan Xu, Xiaowei Zhang, Zhenqiang Zhang. (2022) Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:35151834] [10.1016/j.jep.2022.115101] |
| 10. Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang. (2021) A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression. Journal of Materials Chemistry B, 10 (4): (607-624). [PMID:34994373] [10.1039/D1TB01455B] |
| 11. Hong Zhang, Shaoting Sang, Huimin Xu, Linghua Piao, Xiande Liu. (2021) Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis. Journal of Functional Foods, [10.1016/j.jff.2021.104693] |
| 12. Ying Xu, Yunxia Dong, Cong Wang, Qian Jiang, Haichao Chu, Yue Tian. (2021) Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation. NEUROCHEMISTRY INTERNATIONAL, [PMID:34048842] [10.1016/j.neuint.2021.105078] |
| 13. Ping-Ting Xiao, Zhi-Shen Xie, Yu-Jia Kuang, Shi-Yu Liu, Chun Zeng, Ping Li, E-Hu Liu. (2021) Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway. Acta Pharmaceutica Sinica B, [PMID:34900535] [10.1016/j.apsb.2021.03.031] |
| 14. Na Deng, Ziqian He, Ruixue Guo, Bisheng Zheng, Tong Li, Rui Hai Liu. (2020) Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:32985184] [10.1021/acs.jafc.0c04780] |
| 15. Guihua Yan, Yunchao Feng, Zhebang Gao, Xianhai Zeng, Wenjing Hong, Wenjie Liu, Yong Sun, Xing Tang, Tingzhou Lei, Lu Lin. (2019) Stable and Biocompatible Cellulose-Based CaCO3 Microspheres for Tunable pH-Responsive Drug Delivery. ACS Sustainable Chemistry & Engineering, [10.1021/acssuschemeng.9b05144] |
| 16. Kun Wang, Chuan Yu, Yang Liu, Wendiao Zhang, Yanan Sun, Yong Chen. (2018) Enhanced Antiatherosclerotic Efficacy of Statin-Loaded Reconstituted High-Density Lipoprotein via Ganglioside GM1 Modification. ACS Biomaterials Science & Engineering, [PMID:33418777] [10.1021/acsbiomaterials.7b00871] |
| 17. Yu Zhang, Shiguo Chen, Chaoyang Wei, Jianchu Chen, Xingqian Ye. (2016) Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves regulate lipid metabolism and glucose consumption by activating AMPK pathway in HepG2 cells. Journal of Functional Foods, [10.1016/j.jff.2016.12.030] |
| 18. Zu-Guo Zheng, Ya-Ping Zhou, Xin Zhang, Pyone Myat Thu, Zhi-Shen Xie, Chong Lu, Tao Pang, Bin Xue, Da-Qian Xu, Yan Chen, Xiao-Wei Chen, Hui-Jun Li, Xiaojun Xu. (2016) Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. BIOCHEMICAL PHARMACOLOGY, [PMID:27816546] [10.1016/j.bcp.2016.10.016] |
| 19. Zhi-Shen XIE, Ling-Jun ZHONG, Xiao-Meng WAN, Meng-Ning LI, Hua YANG, Ping LI, Xiao-Jun XU. (2016) Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs. Chinese Journal of Natural Medicines, [PMID:28236404] [10.1016/S1875-5364(16)30089-9] |
| 20. Mengdi Zhang, Zhaoxin Wang, Siyu Hao, Lei Hao, Xinying Zhang, Peng Yu, Hua Sun. (2020) Synthesis of natural 3′-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, [PMID:32791402] [10.1016/j.ejmech.2020.112649] |
| 21. Junfeng Li, Min Guo, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren. (2024) Ameliorative potential of ellagic acid via PPARγ against hyperlipidemia: Insights from mice and zebrafish. Food Bioscience, [10.1016/j.fbio.2024.105582] |
| 22. Jie Zhao, Gai Gao, Jing Ding, Wei Liu, Tao Wang, Liang Zhao, Jiangyan Xu, Zhenqiang Zhang, Xiaowei Zhang, Zhishen Xie. (2024) Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:39226078] [10.1021/acs.jafc.4c03172] |
| 23. Qiuyan Jiang, Tiehua Zhang, Yuan Liang, Jie Zhang. (2024) Baicalein ameliorates lipid accumulation in HepG2 cells via the pregnane X receptor signaling pathway. Food Bioscience, [10.1016/j.fbio.2024.104482] |
| 24. Lin Fu, Hengxin Ren, Chaoxing Wang, Yaxin Zhao, Bohang Zou, Xiangyu Zhang. (2025) Formation of PEG-PLGA Microspheres for Controlled Release of Simvastatin and Carvacrol: Enhanced Lipid-Lowering Efficacy and Improved Patient Compliance in Hyperlipidemia Therapy. Polymers, 17 (5): (574). [PMID:40076067] [10.3390/polym17050574] |
| 25. Kun Miao, Yawei Zhao, Ning Xue. (2024) Gkongensin A, an HSP90β inhibitor, improves hyperlipidemia, hepatic steatosis, and insulin resistance. Heliyon, [PMID:38655315] [10.1016/j.heliyon.2024.e29367] |
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