npj Biofilms and Microbiomes
·
2025
·Vol. 11
·期 1
·1-14
·
IF 9.2
Zhang Song-xia,Hu Fang-fang,Chen Huan,Guo Jing,Xiang Zhong-wen,Ding Xin,Ye Meng-ling,Ye Wen-li,Chen Jun-hong,Wang Xin,Han Wen-jing,Zhou Hong-hao,Zhang Wei,Huang Yun,Wu Lie-lin,Lian Guang-hui,Chen Yao
Drug tolerance is clinically common but its mechanism is unclear. Previous studies found RSV tolerance in ALD treatment. This study explores mechanisms involving gut bacteria and host factors. Male C57BL/6J mice were induced into ALD with the Lieber-DeCarli alcohol diet, then ALD-RSV group mice were gavaged RSV (150 mg/kg/day) for 5 weeks. Throughout the experiment, ALD and ALD-RSV mice were on the Lieber-DeCarli alcohol diet, while the Vehicle group received a control diet. By week 5, tolerance to RSV efficacy emerged, with markedly reduced RSV exposure at the final dose. ALD-RSV group exhibited increased levels of Eggerthella lenta ( E.lent ), which metabolizes RSV into dihydroresveratrol (DHR). Chronic RSV treatment upregulated UGT1A1, the enzyme converting RSV into its primary metabolite, trans-resveratrol-3-O-β-D-glucuronide (R3G). The synergy between gut bacteria and host factors enhances RSV metabolism in ALD mice, driving tolerance and offering insights into other clinical drugs tolerance mechanisms.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mofei Han,Kaiqi Tang,Zhenhua Chen
Periodontitis, as a chronic inflammatory oral disease, is the primary cause of tooth loss. The oxidative stress microenvironment of periodontitis causes damage of both osteoblasts’ mitochondrion and periodontal tissue. Natural extracts with antioxidant properties, including resveratrol (RSV), have been reported in regulating oxidative stress microenvironment, however, the controlled release of them in periodontal tissue is still a challenge. Herein, a smart photothermal-responsive gold nanocages hydrogel (RSV-Au@H) was constructed for the treatment of periodontitis by controlling the release of resveratrol. Under the near-infrared (NIR) light irradiation for 5 min, RSV-Au@H could be heated to 45.8 ℃ due to the good photothermal effect of Au nanocages encapsulated in the hydrogel. This NIR stimulated photothermal effect of RSV-Au@H could control the release of RSV. Molecular biology indicated that RSV-Au@H could scavenge ROS with 42 % efficiency. Transmission electron microscopy (TEM) showed a significant improvement in osteoblasts mitochondrial morphology. Micro-CT scanning revealed that RSV-Au@H reduced the distance between cemento-enamel junction and alveolar bone crest (CEJ-ABC) by up to 55 % and increased bone volume fraction by about 48 %. These results suggested that this multifunctional nanoplatform with NIR controlled release of RSV might be a new therapeutic strategy for periodontitis.
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CELL BIOCHEMISTRY AND BIOPHYSICS
·
2025
·
IF 2.5
Wang Hong,Li Feilong,Mei Yongliang,Wu Taotao,Wang Liquan,Hao Pandeng,Ci Shenjing,Liu Zongchao
Intervertebral disc degeneration (IVDD), characterized by lower back pain, is a prevalent chronic orthopedic disease imposing significant physical and economic burdens. However, the molecular mechanisms of IVDD remain insufficiently explored, hindering clinical guidance. This study aimed to identify key targets of IVDD via bioinformatics, providing new therapeutic directions. Gene expression profiles GSE34095 and GSE150408 were retrieved from public databases, and IVDD-related gene datasets were obtained from GeneCards and CTD. Protein-protein interaction (PPI) networks were constructed, followed by functional enrichment analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Reactome Pathway Knowledgebase (Reactome), and WikiPathways. Key genes associated with the ferroptosis pathway were screened, and the effect of resveratrol on IVDD was validated via in vitro and in vivo experiments. Enrichment analyses identified ferroptosis as the major signaling pathway in IVDD. Six key genes (Glutathione Peroxidase 4 (GPX4), Transferrin receptor (TFRC/TFR1), Solute Carrier Family 7 Member 11 (SLC7A11/xCT), Hypoxia Inducible Factor 1 Subunit Alpha Gene (HIF1A), Interleukin-6 (IL6), and Interleukin-1 Beta (IL1B)) were selected. In vitro studies showed that resveratrol inhibited ferroptosis in nucleus pulposus cells (NPCs), while in vivo experiments in rats confirmed that resveratrol alleviated IVDD by regulating ferroptosis-related genes. Molecular docking validated the binding of resveratrol to these key targets. This study demonstrates that resveratrol delays IVDD progression by inhibiting ferroptosis in NPCs, providing a novel therapeutic strategy for clinical IVDD prevention and treatment.
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ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Fengling Jiang,Ziwei Lan,Yongzheng Ma,Yuan Zhang,Xiaoqing Li,Dickon H.L. Ng,Jia Li
Micro/nanomotors have demonstrated significant potential in environmental monitoring and water remediation owing to their enzyme-like catalytic properties and self-driven ability. Herein, we developed a conical Co(OH) 2 @MnO 2 micromotor through an integrated oil bath-hydrothermal synthesis strategy. The micromotors feature MnO 2 nanosheets arranged in a two-dimensional cross-array architecture on their microconical surfaces, which effectively catalyze H 2 O 2 decomposition to produce oxygen bubbles, enabling robust self-propulsion. The speed of the micromotor can reach 138.59 ± 2.03 μm/s in7 wt% H 2 O 2 solution. The combination of excellent enzyme-like activity and self-driven ability of micromotor constructs a dynamic sensitive detection platform for resveratrol (RES, 3,4′,5-trihydroxystilbene), a potential pollutant in water, with a low concentration detection limit of 0.23 μM. In addition, hydrogen peroxide and peroxymonosulfate (PMS) were used as catalytic substrates to catalyze the micromotor to generate various reactive oxygen species (ROS), thus achieving efficient synergistic degradation of resveratrol. Under neutral pH conditions, the degradation rate of resveratrol by the micromotors was 91.6% within 40 min. This study provides an intelligent strategy for developing dynamic sensors with the dual functions of detecting and degrading RES simultaneously.
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Stem Cell Reviews and Reports
·
2026
·
IF 4.9
Lv Yan,Du Yongjun,Peng Zhi,Ma Chengjie,Li Zhenggang,Xu Rui,Hou Jianhong,Lu Sheng
Osteoporotic fracture is the most severe complication of osteoporosis, and impaired bone regeneration and delayed healing after fracture remain major clinical challenges. Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (BMSCs) may play a critical role in promoting bone regeneration after osteoporotic fracture. Enhancing their osteogenic potential and elucidating the underlying mechanisms may contribute to accelerated fracture healing. In this study, resveratrol-stimulated BMSC-derived EVs (Res-EVs) were isolated using differential centrifugation combined with ultracentrifugation. We found that compared with EVs secreted by BMSCs under normal culture conditions (Nor-EVs), Res-EVs significantly enhanced BMSCs osteogenic differentiation capacity. Analysis of miRNA sequencing data identified miR-19a-3p as significantly downregulated and PC-3p-83,608 as significantly upregulated. The reliability of the sequencing data was validated by qPCR results. By transfecting BMSCs with inhibitor and mimic of miR-19a-3p, we found that miR-19a-3p was a negative regulator of osteogenic differentiation. Bioinformatics prediction and dual-luciferase reporter assays confirmed that miR-19a-3p directly targets Raf1. Western blot results indicated that miR-19a-3p regulates osteogenic differentiation of BMSCs by targeting Raf1. In vivo experiments further demonstrated that Res-EVs treatment enhanced repair at osteoporotic fracture sites and increased the expression of RUNX2 and RAF1. Collectively, these findings indicate that Res-EVs promote bone regeneration at osteoporotic bone defect sites in rats, with the miR-19a-3p/Raf1 axis representing a potential underlying mechanism.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Zhao Jun,Tuo Wenbi,Xiong Siwei,Yi Xiaoli,Zhang Weidong,Tian Yunzhi,Du Yingying,Shu Yanqing,Jia Jiehao,Zhang Chen,Qu Yan
Resveratrol (Res) is a plant polyphenol with diverse
bioactivities,
yet its application is limited by poor water solubility and low bioavailability.
Therefore, an edible nanodelivery system composed of a zein/citric
acid complex was developed to encapsulate Res@ZC-NPs showed high encapsulation
efficiency, average particle size of 66.16 ± 1.19 nm and PDI
of 0.176. In vitro , ZC-NPs inhibited oxidative stress-induced
reactive oxygen species production and promoted cellular uptake. In vivo , the nanoparticles effectively delivered res to
the colon, prolonged its retention, alleviate dextran sulfate sodium
(DSS)-induced colitis in mice, preserve colonic tissue integrity,
restore intestinal barrier function, and partially reshape gut microbiota
composition. Overall, this study developed an oral nanosystem based
on natural edible materials, providing an ideal delivery strategy
for plant polyphenol-based active ingredients in treating ulcerative
colitis.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Shuhan Yong,Shanglin Li,Ting Zhang,Jingbo Liu,Zhiyang Du
Protein–polysaccharide hydrogels with clear gelation mechanisms and gastrointestinal robustness are attractive carriers for hydrophobic nutraceuticals. Here, a hydrogel composed of ovalbumin (OVA), konjac glucomannan (KGM), and genipin (GP), hereafter referred to as the OVA–KGM–GP hydrogel, was developed and found to form a self-supporting gel at room temperature. Apparent thermokinetic fitting provided an early clue that the OVA–KGM–GP system exhibited an integrated dehydration-stage signature rather than a simple additive thermal response, with ΔS ‡ values of −77.03 J mol −1 K −1 for OVA–KGM–GP and −88.55 J mol −1 K −1 for OVA–GP. Multiscale characterization further demonstrated that KGM guided OVA pre-assembly into interconnected structures, while GP fixed and compacted these structures into junction-like domains, yielding a hierarchically integrated lamellar–honeycomb network with elastic-dominant behavior. The hydrogel also exhibited enhanced gastric resistance, evidenced by a lower free amino group content after 2 h of simulated gastric digestion. As a delivery matrix, the hydrogel achieved a resveratrol encapsulation efficiency of 98.23%, and the bioaccessibility after 4 h simulated gastrointestinal digestion reached 70.23%, nearly two-fold that of free resveratrol (35.78%). These results support a bridging-locking assembly pathway for gelation and highlight its potential for hydrophobic nutraceutical delivery.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·
IF 3.3
Nai-Cui Liu,Yu-Zhu Zhao,Tao Zhan,Moldir Rustem,Zhencheng Chen,Guo-Cheng Han,Xiao-Zhen Feng,Heinz-Bernhard Kraatz
Trans-resveratrol (TRA) has garnered significant attention due to its multiple pharmacological activities. This study fabricated a Zn-MOF/MWNTs-OH/GCE electrochemical detection platform for TRA detection by modifying a glassy carbon electrode (GCE) with a composite of hydroxyl-functionalized multi-walled carbon nanotubes (MWNTs-OH) and zinc-based metal-organic framework (Zn-MOF). The structure and composition of the materials were characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. The results indicate that the Zn-MOF/MWNTs-OH/GCE has an excellent electrochemical response to TRA, featuring a linear detection range of 1.00- 600.00 μM and a detection limit of 0.32 μM. Additionally, the detection platform exhibits good reproducibility, stability, and selectivity. In the grape skin sample detection, the recovery rate ranges from 98.48% to 105.19%, the RSD is less than 4.62%, and the accuracy of the results is verified by fluorometry.
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Journal of Materials Chemistry B
·
2026
·
IF 6.2
Qirui Bi,Danni Liu,Yunfei Tan,Pengyu Hu,Qiulan Tong,Lei Ma,Jianming Jiang,Xudong Li,Zeng Yi
The combined application of photothermal therapy (PTT) and chemotherapy (CT) has emerged as a focal area to seek novel nanomedicines for enhanced cancer therapy.To date, there are burgeoning efforts directed toward the development of different carriers for codelivery of chemotherapeutic drugs and photosensitizers to give rise to potent anticancer nanomedicines with synergistic effects. Herein, phenylboronic acid-functionalized resveratrol (Res) oligomers were synthesized as nanocarriers in organic solvent via a Mannich condensation and with the addition of water, Res-based nanomedicines containing doxorubicin (Dox) and IR780 were conveniently achieved.3-Aminophenylboronic acid (3AP) and 4-Aminophenylboronic acid pinacol ester (4APE) were applied to prepare two kinds of nanomedicines, RsvDI and RevDI NPs. Physicochemical characterization revealed that both RsvDI and RevDI NPs exhibited spherical morphology, uniform particle size distribution, good colloidal stability, high encapsulation efficiency, and drug loading capacity. Photothermal performance evaluation confirmed that both nanomedicine formulations possessed excellent photothermal conversion efficiency. In vitro release studies demonstrated that Dox release was significantly enhanced under irradiation and acidic conditions, with RevDI NPs showing superior drug release kinetics. Cytotoxicity assays demonstrated that the active Res nanocarriers effectively inhibited the proliferation of multiple cancer cell lines while preserving the therapeutic efficacy of the encapsulated drugs.Cell uptake experiments further validated that both nanomedicines were efficiently internalized by tumor cells through the sialic acid-phenylboronic acid targeting mechanism and RevDI NPs, owing to their higher density of PBA groups, exhibited a better target enrichment effect. Animal studies demonstrated that the Res-based nanomedicines significantly enhanced the anti-cancer effects through the chemo-photothermal synergy, particularly RevDI NPs. The comparison using protected and unprotected PBA groups not only deepens the understanding of protective group mechanisms in nanocarrier design but also provides crucial experimental support for developing highly efficient and low-toxicity targeted nanomedicines.
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COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.3
Zhang Hongmei,Wang Pengge,Yang Yunxia,Zhu Daliang,Wang Yanqing
Succinoglycan riclin (RIC), a natural polysaccharide with diverse biological activities, was employed as a drug carrier to construct a novel nanoplatform. Polysaccharide-Pt(IV) conjugates were synthesized via esterification between the hydroxyl groups of RIC and a Pt(IV) prodrug, which was subsequently loaded with resveratrol (RES) to form the RES@RIC-Pt(IV) nanoplatform. The successful synthesis and physical properties of the complex were confirmed through multiple characterization techniques. Pt(IV) was significantly bonded to the polysaccharide chain. The drug loading capacities for platinum and RES were quantified using ICP-OES and UV–Vis spectrophotometry, respectively. The percentage of Pt content in RIC-Pt (IV) conjugates can be calculated as 11.71%. In vitro cytotoxicity assays revealed that the RES@RIC-Pt(IV) platform exhibited significantly enhanced toxicity against HepG2 and LO2 cancer cell lines compared to individual small-molecule drugs. These results demonstrate that this multi-drug delivery system achieves a potent synergistic anticancer effect, highlighting its potential for improved cancer therapy. Graphical abstract
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 137
·期 38
·49122
·
IF 2.52
Zongwei Guo,Mengjie Zhang,Yuansi Zhang,Liu Liu,Ming Li,Lei Shang,Yuhui Ao
Environmentally friendly materials are an integral part of sustainable chemistry, and bio-based polymer composites are an important class of materials. The manufacture of composites is expected to reduce or even eliminate the use of adjuvants, considering the importance of reducing energy consumption and avoiding health and environmental risks. In this study, a phenyl-containing, polyfunctional, bio-based epoxy resin (TGER) was synthesized, and carbon fiber-reinforced, bio-based epoxy resin composites were fabricated by vacuum-assisted resin infusion using two aromatic amine curing agents, 4,4′-diaminodiphenylmethane (DDM) and 3,3′-diethyl-4,4′-diaminodiphenylmethane (DEDDM). Curing reactions and rheological behavior studies showed that TGER had higher curing reactivity toward DDM and DEDDM than to diglycidyl ether of bisphenol A (DGEBA) and possessed good processability. The results indicated that the resveratrol-based epoxy resin displayed low-temperature fast curing properties. The evaluation of the mechanical properties of the carbon fiber composites showed that the flexural strengths of CF/TGER/DDM and CF/TGER/DEDDM were 520 and 628 MPa, respectively. The initial decomposition temperature of CF/TGER composites is above 200°C. Furthermore, the carbon fiber–reinforced biopolymers possess excellent heat resistance. Therefore, carbon fiber-reinforced, resveratrol-based epoxy resin composites are promising candidates as alternatives to petroleum-based high-performance carbon fiber composites.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Licong Yang,Yabin Wang,Guodong Zheng,Zhiwei Li,Jingtao Mei
Resveratrol (Res) is a common natural polyphenol that inhibits inflammation and oxidative stress in Alzheimer's disease (AD). However, the absorption efficiency and in vivo bioactivity of Res are poor. High fat diet-induced metabolic disorders, including obesity and insulin resistance, can promote AD-related β-amyloid (Aβ) aggregation, Tau protein phosphorylation and neurotoxicity. Gut microbiota play a role in modulating metabolic syndrome and cognitive impairment. Herein, flower-like Res-loaded selenium nanoparticles/chitosan nanoparticles ( [email protected] @Res-CS-NPs) with higher loading capacity (64 %) were prepared to regulate gut microbiota in cases of AD with metabolic disorder. The nano-flowers could restore gut microbiota homeostasis to reduce lipopolysaccharide (LPS) formation and LPS-induced neuroinflammation. Additionally, [email protected] @Res-CS-NPs can prevent lipid deposition and insulin resistance by decreasing Firmicutes levels and increasing Bacteroidetes levels in the gut, further inhibiting Aβ aggregation and Tau protein phosphorylation through the JNK/AKT/GSK3β signaling pathway. Moreover, [email protected] @Res-CS-NPs treatment was able to regulate the relative levels of gut microbiota associated with oxidative stress, inflammation and lipid deposition, including Entercoccus , Colidextribacter , Rikenella , Ruminococcus , Candidatus_Saccharimonas , Alloprevotella and Lachnospiraceae_UCG-006 . Overall, [email protected] @Res-CS-NPs significantly enhances cognitive ability in AD mice with metabolic disorder, highlighting their potential for preventing cognitive impairments in AD.
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