Advanced Healthcare Materials
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2025
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IF 9.6
Hao Cui,Chen Ni,Mengmeng Wang,Jie Huang,Danyang Qu,Jinfeng Yang,Xingqi Pan,Zhenbao Liu,Meilin Shi
Breast cancer progression is closely associated with hypoxia, which severely limits the efficacy of conventional therapy. In addition, the lack of real-time imaging hampers accurate monitoring of therapeutic processes, further reducing treatment precision and efficacy. Here, the rational design of a multifunctional nanoplatform that integrates hypoxia relief, dual-modality imaging, and synergistic therapy to overcome these barriers is reported. Mesoporous polydopamine nanoparticles are engineered and sequentially functionalized with the sonosensitizer chlorin e6 (Ce6), oxygen-generating manganese dioxide, and the targeting antibody cetuximab, yielding MPDA-Ce6@MnO 2 -C225 (MCMC NPs). This construct exhibits a uniform nanoflower-like architecture, high Ce6 encapsulation efficiency, and robust oxygen supply capacity. By simultaneously enhancing reactive oxygen species generation and chemodynamic activity, MCMC NPs achieve potent SDT/CDT synergy under ultrasound activation. Importantly, they provide sensitive dual-modality fluorescence and magnetic resonance (MR) imaging, enabling real-time monitoring of nanoparticle distribution and therapeutic response. In vitro studies confirm excellent biocompatibility, targeted uptake by 4T1 breast cancer cells, and significant MRI signal enhancement. In vivo, MCMC NPs effectively alleviate tumor hypoxia, markedly suppress tumor growth, and prolong therapeutic response. This study establishes MCMC NPs as a versatile nanotheranostic platform that integrates imaging with oxygen-augmented SDT/CDT, offering a promising strategy for precise and effective breast cancer treatment.
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Advanced Optical Materials
·
2025
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IF 7.2
Heng Guo,Jiajun Ma,Fangfang Zhang,Zhuxin Li,Linlin Shi,Xiaowei Wang,Xiaoli Duan,Ganesan Annadurai,Jakrapong Kaewkhao,Yizhi Zhu
The increasing demand for radiation detection in applications like medical diagnostics and security inspection drives scintillator research. Traditional scintillators are limited by toxicity, crystallization challenges, and high production costs. A one-step chemical vapor deposition (CVD) method is developed to produce high-purity, large-area, and uniform Cs 3 Cu 2 Cl 5 microcrystalline film. This material utilizes a unique self-trapped exciton (STE) emission mechanism, resulting in significant Stokes shift of 241 nm and a high photoluminescence quantum yield (PLQY). It offers new opportunities for converting X-ray and high-energy radiation. It shows a linear RL intensity increase with dose rates (25–188 µGy s −1 ), excellent dose-response linearity, and high absorption coefficients comparable to commercial scintillators. This X-ray imaging system allows for high-resolution visualization of internal chip structures even at low doses. This work establishes a controllable synthesis method for large-area scintillator films and highlights the potential of Cs 3 Cu 2 Cl 5 microcrystalline film as a next-generation scintillators materials.
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Advanced Optical Materials
·
2025
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IF 7.2
Jianwei Gong,Tingting Wu,Zhijian Yang,Xiaoling Chen,Qinxia Wu,Tianci Jiang,Xinqi Xu,Zhenzhen Zhang,Qiushui Chen,Xiaofeng Chen,Huanghao Yang
Achieving high loading, uniformly dispersed scintillators in polymer matrices remains challenging for flexible X-ray detectors. Herein, a large-area NaLuF 4 :Tb@WPU scintillator film (48 × 20 cm 2 ) is reported that synergistically integrates solution-processed NaLuF 4 :Tb scintillators with waterborne polyurethane (WPU), enabling a record-high 90.4 wt% loading with uniform dispersion. Optimized interfacial compatibility ensures outstanding operational durability with 99.5% radioluminescence intensity retention and <0.5% permanent bending deformation after 2000 bending cycles. The X-ray scintillator film demonstrates a low detection limit of 20.9 nGy air s −1 alongside environmental, thermal, and radiation stability. Crucially, it highlights high-resolution thermally-stimulated luminescence X-ray imaging (29.0 lp mm −1 ) with minimal geometric distortion (<1.1%) on curved surfaces, overcoming parallax artifacts in rigid detection. This work establishes a novel flexible platform unifying high sensitivity and spatial resolution for medical/industrial X-ray imaging.
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ANALYTICAL CHEMISTRY
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2025
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IF 6.7
Xiaoxuan Ren,Yue Sun,Shengjie Li,Xuwen Gao,Guizheng Zou
The unary nanocrystals (NCs) of copper are frequently employed as a catalyst, sensitizer, and energy transfer mediator of chemiluminescence (CL). Herein, the direct and defect-involved CL of copper NCs (CuNCs) for the semiautomatic immunoassay is proposed with bovine serum albumin (BSA)-stabilized CuNCs (BSA-CuNCs) as luminophores. The biocompatible BSA-CuNCs are a kind of n-type NC that can directly give off flash CL via charge annihilation between its endogenous electrons and exogenously injected holes by the coexisting oxidative activators. Potassium hexacyanoferrate(III) (K3[Fe(CN)6]) can trigger BSA-CuNCs with efficient CL around ∼701 nm, a waveband longer than all commercial-available CL reagent kits. The coexisting citric ion can also directly reduce the hole-injected BSA-CuNCs to further enhance CL emission. The CL of BSA-CuNCs/K3[Fe(CN)6] in citrate buffer is consequently utilized to detect myoglobin on the commercialized and semiautomatic IVD device, which exhibits improved determination performance compared to the commercially available CL reagent kits, with a wide linear response range from 0.25 to 1000 pg/mL and a limit of detection of 0.10 pg/mL (S/N = 3). BSA-CuNCs can be safely stored in pure water and label protein without unintended precipitation, which might provide an alternative to the molecule tagged CL reagent kits.
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ACS Applied Nano Materials
·
2025
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IF 5.5
Sifang Zhao,Fengjiao Chen,Mengxin Ban,Jian Zhou,Kerong Wu,Tengbo Yu,Bowen Chen,Lingling Zhao,Ziyu Liu
The specific targeted drug delivery is crucial for antitumor therapy. In this study, phenylboronic acid (PBA)-modified and ROS-responsive biomimetic polymeric nanoparticles have been developed for the targeted delivery of the antitumor drugs. Nanoparticles were constructed by encapsulating doxorubicin (DOX) through the self-assembly of phenylborate pinalol conjugated dextran, followed by erythrocyte camouflage and PBA modification. The particulate size of nanoparticles was 128.3 ± 11.0 nm, which increased slightly to 171.0 ± 10.4 nm after erythrocyte camouflage and PBA modification. The nanoparticles showed sustained and ROS-triggered drug release in vitro. They had excellent colloidal stability in PBS and 10% FBS due to the erythrocyte camouflage, which can help to prolong their blood circulation time. The cellular uptake of nanoparticles was remarkably enhanced due to PBA modification, and the inhibition of cell migration and cell invasion was also promoted. The nanoparticle system can effectively promote the apoptosis of B16F10 cells and show a good antitumor effect in vitro. Thus, this PBA-modified and ROS-responsive biomimetic nanoparticle system has promising application prospects as a tumor-targeted drug delivery system.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
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IF 11.3
Xiaotu Liu,Xinyu Zhu,Shuyue Wang,Fengli Zhou,Ning Zhang,Ziliang Wang,Maohua Miao,Hong Liang,Meilin Yan,Xiangfei Sun,Da Chen
Urinary exposome analysis faces analytical challenges due to the lack of reference standards for biotransformed products and the wide structural diversity of metabolites. This study developed a chemically labeled exposome analysis (CLEAN) strategy for nontargeted identification of urinary metabolites. The strategy uses dansyl chloride (DnsCl) and N-methylphenylethylamine (MPEA) to label exogenous and endogenous molecules with phenolic hydroxyl, primary amine, and carboxyl groups and develops an integrated screening workflow based on diagnostic fragment ion filtering and machine learning-assisted retention time prediction and structure annotation. We applied the CLEAN strategy to screen for key environmental chemicals in pregnant women associated with small vulnerable newborns (SVN) in a nested case-control study of 80 SVN cases and 160 matched controls. Among 97 identified exogenous substances, 29 were detected in more than 70% samples. The BKMR analysis revealed a significant and positive association between mixed exposure and the SVN risk and identified 1-hydroxypyrene, monoisopropyl phthalate and pentabromophenol as the key exposure markers. Among the identified endogenous metabolites, four amino acids exhibited the strongest mediation effects on the environmental exposure–SVN associations. Collectively, our work demonstrates the ability of CLEAN to achieve high-throughput and accurate urinary exposome characterization, supporting large-scale human biomonitoring and epidemiological studies.
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ACS Catalysis
·
2025
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IF 13.1
Shitao Sun,Ziyi Liu,Junqing Li,Wenhao Meng,Huan Yang,Miaobei Zhang,Hanyang Sun,An-Hui Lu,Dongqi Wang
The direct propane dehydrogenation (PDH) reaction constitutes one of the key routes for the production of propylene and relies on the development of high-performance catalysts, which is generally achieved following a time-consuming trial-and-error strategy. In this study, a workflow of machine learning running five stages, i.e., data preparation and the development of a reliable machine learning model and its evaluation, interpretation, and application, was established to explore the data-driven research paradigm in the screening and design of catalysts for PDH with propylene yield as the target. Data from the literature on the PDH reaction catalyzed by alumina-supported catalysts were compiled. Twelve algorithms were evaluated, and the CatBoost model exhibits a high accuracy and generalization capability, with a coefficient of determination (R2) value of 0.992 for the training set and 0.973 for the test set. By employing this model, we screened two highly promising ternary catalysts. Experimental validation demonstrates that the predicted values for these two catalysts are in close agreement with the measured instantaneous propylene yields. Among the screened catalysts, PtSnZr/γ-Al2O3 exhibits a high propylene yield and maintains over 50% yield for 13.5 h. The instantaneous propylene yields on these catalysts are predicted to be further improved upon H2S pretreatment conditions. Explainable machine learning tools (Shapley additive explanations and partial dependence plot analysis) were employed to interpret the model. This study offers valuable insights into the application of machine learning in the heterogeneously catalyzed conversion of light alkanes and aids in the development of catalysts by uncovering a hidden structure–activity relationship in literature data.
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Chemical & Biomedical Imaging
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2025
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IF 5.7
Dongni Han,Mingke Jiang,Rongrong Pan
Spatially resolved analysis of secreted enzyme activity at the single-cell level is critical for understanding extracellular matrix (ECM) remodeling in cancer. This study introduces a label-free electrochemiluminescence (ECL) microscopy method that visualizes lysyl oxidase (LOX) activity secreted by individual tumor cells with subcellular resolution. The approach integrates ECM-localized enzymatic reactions with ECL signal amplification, where LOX-generated hydrogen peroxide enhances luminol-based ECL without external labels. The resulting ΔECL signal directly maps enzyme activity and its spatial heterogeneity across the pericellular region. This platform enables real-time monitoring of LOX inhibition dynamics, phenotypic classification of LOX activity within a breast cancer cell population, and visualization of asymmetric LOX secretion patterns that guide tumor cell migration. These capabilities offer mechanistic insights into ECM-driven tumor invasion and highlight the utility of ECL imaging for high-content single-cell analysis.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Yue Wang,Aofeng Yang,Lihao Xiong,Jiayi Song,Sihan Chen,Huang Zhou,Le Li,Deshuai Zhen
Uranium, a radioactive element, exists in aqueous environments primarily as uranyl ions (UO22+), posing significant risks to human health and the environment. Detecting UO22+ in such environments remains challenging. Here, an upconversion fluorescent sensor (UCDM) for the detection of UO22+ in an aqueous environment was constructed based on the fluorescence resonance energy transfer (FRET) principle. This sensor utilizes upconversion nanoparticles loaded with DNAzyme (UCDA) as energy donors and molybdenum disulfide (MoS2) as energy acceptors. MoS2 exhibits a high affinity for single-stranded DNA (ssDNA), enabling the sensor to function effectively. In the presence of UO22+, DNAzyme catalyzes substrate cleavage at the rA site, releasing ssDNA that binds to MoS2. This interaction leads to a decrease in UCDA upconversion luminescence. The unique upconversion luminescence property of an upconversion nanoparticle minimizes background autofluorescence, enhancing sensitivity. The sensor achieves a low detection limit of 5.81 nM and demonstrates robust recoveries (98.7%–102.7%) in complex aqueous matrices such as Xiangjiang water, uranium mine wastewater, human serum, and urine samples, underscoring its practical applicability.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Yuchun Ren,Xixi Zhang,Chaoxin Yang,Zixiao Li,Yanghua Luo,Shengjun Sun,Fatma A. Ibrahim,Mohamed S. Hamdy,Imran Shakir,Guanwei Cui,Xuefei Liu,Xuping Sun,Bo Tang
Direct seawater electrolysis is promising for green hydrogen production from earth’s most abundant water resource, but its anode suffers from chloride-induced corrosion. Herein, Ba-doped NiFe layered double hydroxide supported on Ni foam (Ba-NiFe LDH/NF) is demonstrated as a high-performance anode for durable alkaline seawater oxidation. Such Ba-NiFe LDH/NF needs only an overpotential of 342 mV to achieve 1000 mA cm–2 and operates stably for 1500 h with negligible degradation and minimal active chlorine generation. Ba doping not only accelerates catalyst surface reconstruction but also favors the selective adsorption of OH– vs Cl– over the anode. The membrane electrode assembly electrolyzer composed of Ba-NiFe LDH/NF and Pt/C/NF demonstrates stable operation at 1000 mA cm–2 for 500 h.
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ACS Catalysis
·
2025
·
IF 13.1
Yong Tang,Yongqi Zeng,Chunyu Wang,Zhi Wang,Danning Zhao,Chuang Du,Fengxi Li,Lei Wang
The enzymatic Diels–Alder reaction presents an environmentally appealing strategy for synthesizing chiral norbornene scaffolds. In this study, an artificial Diels–Alderase was constructed by incorporating a biotinylated Cu-phenanthroline cofactor (5-NH2Phen-biotin*Cu(NO3)2) into streptavidin and optimizing the enzyme through genetic engineering. The S112D variant of this artificial Diels–Alderase exhibited commendable catalytic performance, facilitating highly enantio- and regioselective Diels–Alder reactions. Employing this method, we synthesized a series of norbornene pyridones with broad substrate scopes and good functional group tolerance under mild conditions, achieving high yields along with good enantio- and regioselectivities. Molecular dynamics (MD) simulations provided insights into the critical complex intermediates involved in the proposed reaction mechanism and clarified the interactions between the Diels–Alderase and its substrates, revealing the structural basis for the generation of the predominant norbornenepyridone conformation and the enhanced selectivity observed with the S112D mutant. Furthermore, quantum mechanics/molecular mechanics (QM/MM) calculations analyzed the reaction energy barriers of possible transition states, elucidating the reason for the formation of the target product from an energetic perspective.
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LANGMUIR
·
2025
·
IF 3.9
Kai Yao,Heng Xu,Xiandie Zhang,Zhijie Fan,Wei Wang,Bizheng Chen,Xiaode Guo
Nitroguanidine (NQ) is a high-nitrogen energetic compound whose high decomposition temperature and incomplete combustion hinder its efficiency and environmental performance. Herein, we report a nanoscale interfacial-catalysis strategy in which lead carbonate (PbCO3) is transformed via high-energy ball milling into nanostructured particles, then ultrasonically dispersed to form intimate contact interfaces with NQ crystals. Detailed structural characterization (XRD, SEM) confirmed the formation of PbCO3 with sub-100 nm dimensions and a high surface area, promoting extensive NQ–catalyst interfacial interactions. TGA–DSC revealed that these engineered interfaces lower the onset decomposition temperature of NQ by up to 23.7 °C and reduce its apparent activation energy from 130.9 to 105.2 kJ·mol–1, indicative of accelerated surface-mediated bond rupture. TGA-FTIR analyses demonstrated that PbCO3 surfaces facilitate early stage heat release and redirect reaction pathways to suppress HCN formation, converting it into cleaner exhaust species. Solid-phase residue examination (XPS, XRD) further demonstrated that the reduction of solid-phase residues in the reaction system improves overall combustion integrity. By elucidating how the interface chemistry of nanostructured PbCO3 regulates the kinetics and product distribution of NQ combustion, a new avenue has been opened for the design of advanced energy materials with customized properties.
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