Advanced Science
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2025
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IF 14.1
Yanli Zhou,Ao Xu,Zhiqi Li,Yifei Wang,Jiawen Yan,Fuyi Jiang,Wei Liu,Xin Gu,Huan Pang,Jian Yang
Conversion-based metal sulfides/selenides anodes are promising for sodium-ion batteries (SIBs) owing to their high capacities and good electronic conductivity. However, their large volumetric variation during cycling often leads to rapid capacity decay, hindering commercial applications. Meanwhile, developing a low-cost and efficient synthesis strategy to enhance sodium storage remains challenging. Herein, defect engineering is introduced in bulk Fe 7 Se 8 (bulk-Fe 7 Se 8-x ) to fabricate a carbon-free and defect-rich anode. The optimized bulk-Fe 7 Se 8-x realizes remarkable fast-charging performance and good temperature adaptability, achieving excellent cyclic stability (384 mAh g −1 after 1300 cycles at 5 A g −1 and 25 °C, 170.6 mAh g −1 after 1000 cycles at 2 A g −1 and 0 °C, and 371.7 mAh g −1 after 500 cycles at 5 A g −1 and 40 °C) and ultrahigh rate capability (up to 40 A g −1 ), significantly surpassing reported Fe 7 Se 8 anodes. Reaction mechanism and reaction kinetics are elucidated through in/ex situ characterization, kinetics analysis, and DFT calculations. Furthermore, the exploration of full cells demonstrates their potential application of bulk-Fe 7 Se 8-x in SIBs. The universal strategy is also successfully applied to synthesize the high-performance, defect-rich bulk-Fe 7 S 8-x and bulk-CoSe 2-x , which provides an effective approach for other conversion-based anode materials.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Yi Liu,Xujie Cui,Minhao Guo,Jinmei Wu,Yulan Zhao,Guangzheng Zhang,Jiahui Xu,Heyou Han,Weihui Li,Zhiyong Song
Drug-resistant bacterial infections pose a significant threat to global health, creating an urgent need for new antimicrobial agents. Reusing approved drugs has gained attention as a strategy to address this issue. In this study, a nano antibacterial platform (DSF@HKUST-1@Dex) that responds to the infection microenvironment is proposed. This platform releases disulfiram (DSF), binds to copper ions in the mildly acidic conditions of infected areas, converting DSF from nontoxic to toxic in situ, thereby inducing bacterial death and enhancing copper ion absorption. Noncatalytic treatment is also initiated for a synergistic antibacterial effect. Excessive copper ions disrupt bacterial metabolism, inhibit the Tricarboxylic acid (TCA) cycle, reduce ATP levels, and induce cuproptosis-like death, significantly enhancing antibacterial efficacy. In a bacterial wound infection model, the platform exhibited excellent antibacterial activity, promoting wound healing and reducing inflammation. Proteomic analysis showed that the platform selectively targeted bacterial peptidoglycan, disrupted the bacterial cell wall, impacted energy metabolism, and inhibited bacterial growth. In conclusion, this nanoplatform offers a promising strategy for treating drug-resistant infections by repurposing old drugs, converting them to toxic forms, and providing a novel antimicrobial approach.
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Advanced Healthcare Materials
·
2025
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IF 9.6
Ya-nan Yao,Ya-wen Zhu,Yu-wen Wei,Xuan Zhou,Shu-di Li,Jing-yi Ma,Jing Qiu
Excessive reactive oxygen species (ROS) around titanium implants under pathological conditions can cause mitochondrial dysfunction, potentially resulting in implant failure or related complications. This study designs a titanium implant functionalized with cerium oxide nanoparticles (CeNPs) using phenylboronic acid-modified hyaluronic acid (HA-PBA) and carboxylated chitosan (CCS) as polyelectrolytes, with the primary objective of modulating the local microenvironment around the implant. Owing to the responsive properties of HA-PBA, the embedded CeNPs are released in an on-demand manner as the coating degrades under different conditions. The Ti-HAPBA/CCS-CeNPs implants not only directly stimulate osteoblast differentiation under physiological conditions but also mitigate oxidative stress-induced mitochondrial dynamics imbalance and dysfunction. This protective effect is achieved by scavenging intracellular ROS, downregulating DRP1 expression, and restoring mitochondrial membrane potential (MMP). The osteoinductive efficacy of the Ti-HAPBA/CCS-CeNPs implants is further assessed using a femoral implantation model in diabetic rats, which demonstrates significantly enhanced bone remodeling and osseointegration at four and eight weeks post-implantation compared to the Ti-SLA group. Collectively, this study demonstrates the therapeutic potential of Ti-HAPBA/CCS-CeNPs implants under both physiological and pathological conditions, and provides a novel biopolymer-based strategy for improving dental implant outcomes.
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Advanced Optical Materials
·
2025
·
IF 7.2
Zhiqi Wang,Yan Wang,Shanfei Liu,Chenchen Guo,Xin Li,Enhao Zhang,Ruiyuan Liu,Xiaohong Zhang
Photochromic–electrochromic dual-responsive devices hold great promise for dynamic optical modulation and energy-efficient smart systems. However, achieving rapid, reversible, and bidirectional color switching remains a significant challenge, limited by unbalanced charge transport and poor interfacial stability. Here, a multiscale synergistic design strategy is presented that integrates nanostructure engineering, charge transport regulation, and interface optimization. Molybdenum-doped tungsten oxide quantum dots are composited with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate to construct a dual-responsive functional layer. Mo doping introduces additional oxygen vacancies in tungsten oxide lattice, enhancing electrochemical activity and facilitating coupled ion/electron transport within the composite. The engineered interfacial architecture suppresses charge accumulation, accelerating the photo response and enhancing the synergistic photoelectric performance. The device fabricated by integrating a functional layer and a hydrogel electrolyte between two indium tin oxide electrodes exhibit bidirectional optical control: under a −3 V bias, visible light-induced coloration is enhanced, reducing transmittance from 19.6% to 10.5%; applying a +1.5 V bias enables ultrafast bleaching within 3 s—6 600 times faster than passive fading. Additionally, the device achieves a temperature drop of 10.25 °C, demonstrating its excellent passive insulation performance. This work offers a pathway toward next-generation chromic devices with fast, reversible, and energy-efficient performance for adaptive optoelectronics and sustainable building technologies.
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Advanced Science
·
2025
·
IF 14.1
Xuan Li,Janar Tursen,Wanbin Zhu,Xufeng Yuan,Hongliang Wang
Improving the adhesion and spreading of pesticides on plant surfaces is essential for maximizing efficacy, yet current approaches often exacerbate pesticide residues, posing risks to environmental and food safety. Sustainable alternatives are urgently needed to enhance pesticide utilization while minimizing collateral harm. Here, a fully bio-based pesticide delivery system is presented constructed from lignin coacervates—formed via hydrophobic and electrostatic interactions between aminated alkaline lignin and sodium lignosulfonate, both readily available industrial byproducts—and used for efficient encapsulation the hydrophobic pesticide abamectin. The resulting formulation improves pesticide retention on leaves, enhances resistance to ultraviolet degradation, and ensures strong adhesion and wetting, critical factors for reducing spray drift and runoff. Importantly, the delivery system enables pH- and laccase-triggered release, aligning with the biological environment of target pests and supporting controlled, prolonged action. By physically shielding the active ingredient, the coacervates reduce non-target exposure and ecological toxicity by a factor of two to three. Moreover, the formulation demonstrates superior removability under household washing, as it can be completely eliminated with only a few simple rinses, thereby substantially lowering the risk of foodborne residues. Overall, this work establishes a sustainable pesticide-delivery platforms that reconciles agricultural efficacy with environmental and food safety imperatives.
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Advanced Optical Materials
·
2025
·
IF 7.2
Chunbiao Liu,Zhihai Liu,Yu Zhang,Yifan Qin,Mengyao Zhang,Wei Jin,Libo Yuan
The optical fiber-based wearable curvature sensor shows great potential for real-time monitoring of human joint motion and smart gesture interaction. However, its limited detection range (typically below 10 m −1 ) and the significant mismatch with the dynamic, large-curvature movements of human joints (> 100 m −1 ) have emerged as critical bottlenecks restricting its practical application. To address this challenge, this study proposes for the first time a hydrogel optical fiber flexible curvature sensor with ultra-wideband response. A fine-core hydrogel flexible optical fiber is fabricated using a drawing-spinning process, and its ultra-flexible characteristics successfully overcome the mechanical constraints of traditional optical fibers, enabling reversible bending deformation with a curvature range from 0 to 139.84 m −1 . To the best of the knowledge, this detection range is the largest curvature detection range in the field of optical fiber curvature sensing. By utilizing the displacement of interference valleys (sensitivity of 0.04 nm m −1 ) and the output light intensity attenuation (sensitivity of 1.97 µW m −1 ) when bending in the hydrogel multimode optical fiber, dual-parameter curvature sensing is achieved. By constructing a multi-joint monitoring platform and combining neural network algorithms, gesture recognition is achieved. This work provides an innovative solution for large curvature detection.
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Advanced Science
·
2025
·
IF 14.1
Qiu-Yu Zhao,Yu-Ying Liu,Li-Wei Hu,Hong-Xi Duan,Ming-Xing Li,Yan-Hui Liu,Jing Jiang,Zhen Lu,Wei-Hua Wang
Addressing antibiotic-resistant bacteria requires the efficient development of antibiotic-free antimicrobial materials. Herein, a high-throughput parallel chromatic-zone screening strategy is developed that enables the simultaneous screening of composition and surface structure, thereby optimizing antimicrobial performance. As an example, a MgCuPdGd alloy library with diverse compositions and nanostructures, consisting of 229 samples with continuous compositional gradients and varied nanostructured morphologies is constructed by integrating magnetron co-sputtering and chemical dealloying. The dealloyed samples exhibit distinct chromatic zones—red, yellow, and green—each associated with unique compositional and microstructural features. Among these regions, the red Cu-rich region demonstrates the most outstanding antibacterial performance, achieving a 95% reduction of viable Staphylococcus aureus ( S. aureus ). Comprehensive characterization confirms that the superior antimicrobial efficiency originates from the synergistic contribution of the CuPd alloy and the optimized nanostructure. Furthermore, the observed correlation among surface color, composition, morphology, and antibacterial performance highlights the predictive capability of the chromatic-zone screening approach, thereby reducing characterization requirements by 90% and enabling morphology and performance estimation across large material libraries. This work not only offers a rapid and cost-effective strategy for identifying antimicrobial materials but also provides a versatile platform adaptable to the development of functional materials for broader biomedical and environmental applications.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Jiamei Fu,Mengqiu Quan,Haiquan Sun,Junyi Zhou,Qingyi Xie,Minghui Cui,Xiaolin Wang,Fenglong Li,Jin Zhu,Jing Chen
In the field of sports medicine, especially in high-intensity sports such as football, basketball, and skiing, ligament injuries are extremely common. However, current artificial ligaments face multiple critical limitations, including suboptimal biocompatibility, limited host tissue integration, insufficient mechanical durability to withstand physiological stresses, and inadequate durability during long-term cyclic loading. To address these challenges, 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone (HCC), which shared structural similarity with naturally occurring chalcones, is employed as the raw material for the chain extender, combined with HMDI and polycaprolactone diol (PCL diol), to synthesize a novel polyurethane (HCMPU). The results showed that the maximum stress of HCMPU-3 reached 42.1 MPa, with an elongation at break of up to 710%. It also demonstrated outstanding durability, maintaining structural integrity without significant degradation after 5000 loading cycles. Additionally, during the initial implantation period, its stability in an enzymatic environment can provide strong support to the human body before new tissue regeneration, making it a promising candidate for an ideal artificial ligament. Moreover, the favorable biocompatibility of HCMPUs is demonstrated through cytotoxicity testing and rat pathological staining sections. Therefore, this work demonstrated the potential of HCMPU to overcome key limitations in current artificial ligaments and advance the development of next-generation materials for ligament repair.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Tianlong Wang,Zhiqing Liu,Xinhui Wu,Lei Zhang,Yan Chen,Yixing Chen,Yiping Luo,Yaqi Liu,Zeeshan Waheed Muhammad,Jinhui Zhao,Duolikun Dilixiati,Zifei Zhou,Long-po Zheng
Biomimetic mineralization as a promising method offers a bottom-up strategy for creating new organic-inorganic hybrid materials for treating bone defects. However, it is insufficient for bone regeneration, a complex biological procedure involving an interaction between osteogenesis and microenvironment. Herein, a biomimetic mineralized scaffold derived from decellularized adipose tissue modified with polyphenol tannic acid (TA@mDAT) is developed, drawing inspiration from the regulation of the microenvironment and the biomimetic strategy. Besides its enhanced mechanical properties by mineralization, the shape-memory effect of the biomimetic mineralized decellularized adipose tissue (mDAT) is also improved, due to the crosslinking structure between decellularized adipose tissue (DAT) and tannic acid (TA). Besides, the TA@mDAT scaffold exhibits excellent biocompatibility and immunomodulation effect, high efficacy in guiding bone regeneration via intramembranous and endochondral ossification, and enhanced H-type vessel formation. Furthermore, the enhanced expression of Dll4 and Hey1 involving the Notch1 signaling pathway is detected in the regenerated bone, indicating that the Dll4-Notch1 signaling pathway may play an important role in bone regeneration. Thus, this work provides a promising method for bone regeneration by triggering periosteal osteogenesis and H-type vessel formation and revealing a potential mechanism in the osteogenic process.
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Advanced Materials Technologies
·
2025
·
IF 6.2
Chengyuan Li,Pengcheng Liu,Yukai Xu,Haizeng Li,Chengchao Wang,Jingwei Chen,Lanxin Ma
Electrochromic materials, prized for their energy efficiency and environmental adaptability, have drawn significant research attention toward energy conservation and sustainability. Conversely, traditional photocured gels face challenges such as high equipment requirements, toxic photoinitiators, and intricate preparation processes. In response, this research develops a facile method for preparing photocured conductive hydrogels, employing tungsten trioxide (WO 3 ) and molybdenum trioxide (MoO 3 ) as non-toxic photoinitiators, such as reliance on UV equipment and toxic photoinitiators. WO 3 and MoO 3 synergistically enhance the photo-response and curing speed, enabling rapid solidification into a conductive hydrogel under sunlight within 3 min. The resulting hydrogel demonstrates remarkable mechanical properties, including 400% elongation, self-healing capabilities (restored conductivity within 5 min), and good water–retention, showcasing excellent performance in flexible electrochromic devices and stress sensors. The present study delves into the gel's curing mechanism, electrical and mechanical properties, and self-healing capability, inspiring future applications in electronic devices, flexible circuits, and smart materials.
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Advanced Optical Materials
·
2025
·
IF 7.2
Jinmei Song,Zichang Wang,Jinghui Han,Zhenjun Chen,Weijun Li,Yuhong He,Mingbian Li,Chao Wang,Hu Huang,Haotong Wei
2D perovskite material shows excellent potential in X-ray detection due to the advantages such as improved moisture stability, low dark current, and suppressed noise fluctuation. However, the soft lattice structure resulting from the flexible organic molecules significantly contributes to the enhanced electron-phonon coupling and nonradiative recombination of carriers, thereby hindering the charge carrier transport and limiting the X-ray detection performance of 2D perovskite. Herein, a sulfur atom-introduced 2-thiopheneethylamine lead iodide (TEA 2 PbI 4 ) perovskite single-crystal is reported. The S atom-induced π–π interactions facilitate a more tightly ordered arrangement of organic molecules within the perovskite, leading to reduced distortion of the inorganic octahedra, which enhances the lattice rigidity and suppresses non-radiative recombination compared to other perovskites. Thus, the TEA 2 PbI 4 perovskite single-crystal exhibits a high sensitivity of 2.45 × 10 4 µC·Gy air −1 ·cm −2 under 80 kV X-ray irradiation. The X-ray detection efficiency of TEA 2 PbI 4 can reach 85%, and the noise-equivalent dose is as low as 82 pGy air , demonstrating its high signal/noise resolution capability.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Yibing Shi,Xiaoyi Zhu,Qingyuan Xu,Yanling Wu,Yishuo Sun,Xin Zhao,Yulong Liu,Wei Feng,Youhua Xie,Tianlei Ying,Zhenlin Yang
The oral administration of immunofluorophores has been limited by gastrointestinal degradation. To address this, a novel immunofluorophore (ICGM-B9-FCS), based on a single-domain antibody-dye targeting the CEACAM5 antigen, is coated with trifluoromethyl chitosan (5 mg kg −1 ) for NIR-II bioimaging of colorectal cancer and its distant metastases. ICGM-B9-FCS demonstrates unique advantages over existing intraoperative tumor-guidance bioagents, including resistance to liver metabolism, well-retained bioaffinity (EC 50 = 58.09 nmol L −1 ), enhanced relative quantum yield (up to 12 equivalents), significant redshifts in absorption (from 783 to 957 nm), effective oral delivery to colonic metastases, and in situ exploration of the capillary-lymphatic network transportation. These findings establish a regulatory pathway for modifying immunofluorophores as orally administered bioagents, offering innovative methods for preoperative diagnosis and intraoperative guidance in colorectal cancer.
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