硫酸新霉素

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货号 (SKU) 包装规格 是否现货 价格 数量
N109017-5g
5g 现货 Stock Image
N109017-25g
25g 现货 Stock Image
N109017-100g
100g 现货 Stock Image
N109017-500g
500g 现货 Stock Image

基本描述

别名 硫酸新霉素 | 硫酸新霉素水合物 | 新霉素三硫酸盐水合物
英文别名 (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)ox
规格或纯度 PharmPure™, USP, 600 I.U./mg
英文名称 Neomycin sulfate
生化机理 作用方式:与引起错编的 30S 和 50S(有时为 50S)亚基结合;抑制蛋白质合成的开始和延长。 抗菌谱:革兰氏阴性和革兰氏阳性细菌。
应用 在没有影响神经元Na+/Ca2+ 反向转运蛋白(antiporter)的情况下阻断电压灵敏的Ca2+ 通道。 结合到核糖体30S 和 50S 亚单位引起蛋白错误编码;在蛋白合成起间抑制起始和延长。 抗菌谱: 革兰氏阴性和阳性细菌。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

溶于水。 水中溶解度:500 g/L (20°C) 在没有影响神经元Na+/Ca2+ 反向转运蛋白(antiporter)的情况下阻断电压灵敏的Ca2+ 通道。 结合到核糖体30S 和 50S 亚单位引起蛋白错误编码;在蛋白合成起间抑制起始和延长。 抗菌谱: 革兰氏阴性和阳性细菌。

应用

新霉素三硫酸盐水合物用于:
1、确定Netrin1编码基因(Ntn1)对耳蜗外植体中氨基糖苷类抗生素的保护作用;
2、大肠杆菌抗生素敏感试验;
3、小鼠骨髓移植

Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins. It is recommended for use in cell culture applications at 50 mg/L.

AI解读

名称和识别符

EC号 215-773-1
分子类型 未知
IUPAC Name (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
INCHI InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChi Key OIXVKQDWLFHVGR-WQDIDPJDSA-N
Canonical SMILES C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
Isomeric SMILES C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
WGK Germany 3
RTECS QP4375000
PubChem CID 197162
分子量 908.88 (anhydrous basis)
Reaxy-Rn 9468364

化学和物理性质

溶解性 Soluble in water
敏感性 对光线和湿度敏感
比旋光度 56° (C=10,H2O)
分子量 712.700 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 15
氢键受体数Hydrogen Bond Acceptor Count 23
可旋转键计数Rotatable Bond Count 9
精确质量Exact Mass 712.28 Da
单同位素质量Monoisotopic Mass 712.28 Da
拓扑极表面积Topological Polar Surface Area 436.000 Ų
重原子数Heavy Atom Count 47
形式电荷Formal Charge 0
复杂度Complexity 953.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 19
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性(GHS)

象形图 GHS08,   GHS07
信号词 Danger
危险声明

H335: 可能引起呼吸道刺激

H373: 通过长时间或反复暴露对器官造成损害

H412: 对水生生物有害并具有长期持续影响

H317: 可能引起皮肤过敏反应

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

H361: 怀疑破坏生育力或未出生的孩子

WGK Germany 3
RTECS QP4375000
Reaxy-Rn 9468364
Merck Index 6454
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

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批号(Lot Number) 证书类型 日期 货号
D2509476 分析证书 25-02-21 N109017
D2509477 分析证书 25-02-21 N109017
D2509478 分析证书 25-02-21 N109017
D2509518 分析证书 25-02-21 N109017
E2113328 分析证书 25-02-07 N109017
J2415531 分析证书 24-09-26 N109017
J2415532 分析证书 24-09-26 N109017
J2415543 分析证书 24-09-26 N109017
L2325157 分析证书 23-12-02 N109017
H2412514 分析证书 23-11-27 N109017
H2421024 分析证书 23-11-27 N109017
L2325158 分析证书 23-11-27 N109017
L2325159 分析证书 23-11-27 N109017
L2325161 分析证书 23-11-27 N109017
L2325162 分析证书 23-11-27 N109017
J2317065 分析证书 23-03-04 N109017
D2306604 分析证书 23-03-04 N109017
D2306728 分析证书 23-03-04 N109017
D2306727 分析证书 23-03-04 N109017
D2306670 分析证书 23-03-04 N109017
D2306632 分析证书 23-03-04 N109017
D2306617 分析证书 23-03-04 N109017
D2306594 分析证书 23-03-04 N109017
L2212284 分析证书 22-12-13 N109017
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L2212286 分析证书 22-12-13 N109017
H2229457 分析证书 22-07-23 N109017
H2229456 分析证书 22-07-23 N109017
H2229455 分析证书 22-07-23 N109017
G2208153 分析证书 22-07-11 N109017

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