计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 提供 ≥95% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 39 篇同行评审文献引用。
概述
EIPA (L593754) 是一种具有口服活性的 TRPP3 通道抑制剂，IC50 为 10.5 μM。EIPA 可通过抑制 Na+/H+-exchanger 3 (NHE3) 来促进自噬 (autophagy)。EIPA 也抑制巨胞饮作用 (macropinocytosis)。EIPA 可用于炎症和癌症的研究，如胃癌、结肠癌、胰腺癌。
规格
别名
5-(N-乙基-N-异丙基)阿米洛利
英文别名
5-(Ethylisopropyl)amiloride | Ethylisopropyl amiloride | EU-0100045 | HY-101840 | SMR000326875 | Tox21_500045 | 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide | DTXSID80151084 | N-Amidino-3-amino-5-ethylisopropylami
规格或纯度
Moligand™, ≥95%
英文名称
EIPA
生化机理
TRPP3通道抑制剂（IC50 =10.5μM）。抑制Na + / H +交换剂（NHE）。阿米洛利的衍生物。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
通道阻滞剂
作用机制
α 2A 肾上腺素受体的异构调节剂；ASIC1 的通道阻断剂；TRPP2 的通道阻断剂
纯度
≥95%
名称和识别符
PubChem SID
EC号
634-217-2
分子类型
小分子
IUPAC Name
3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
INCHI
1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChi Key
QDERNBXNXJCIQK-UHFFFAOYSA-N
Smiles
CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C
Isomeric SMILES
CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C
分子量
299.76
Reaxy-Rn
8708046
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8708046&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机杂环化合物 |
| 类（Class) | 二嗪类 |
| 亚类（Subclass） | 吡嗪类 |
| 中间层级节点（Intermediate Tree Nodes） | 吡嗪羧酸及其衍生物 |
| 直接上位类(Direct Parent) | 吡嗪酰胺类 |
| 其他上位类（Alternative Parents） | 二烷基芳胺 酰基胍 氨基吡嗪类 芳基氯化物 咪唑内酰胺类 乙烯基酰胺 杂芳族化合物 氨基酸及其衍生物 炔丙基型1,3-偶极有机化合物 氮杂环化合物 甲脒类 碳氢化合物衍生物 有机氧化物 有机氯化物 有机氧化合物 有机光子化合物 伯胺 |
| 分子骨架（Molecular Framework) | 芳香族杂单环化合物 |
| 取代基（Substituents） | 酰基胍 - 氨基酸 - 氨基酸或其衍生物 - 氨基吡嗪 - 芳香族杂单环化合物 - 芳基氯化物 - 芳基卤化物 - 氮杂环 - 羧酰亚胺 - 羧酸衍生物 - 二烷基芳基胺 - 胍 - 杂芳香族化合物 - 烃衍生物 - 咪唑内酰胺 - 有机1,3-双极性化合物 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机氯化物 - 有机卤化物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 初级胺 - 丙炔型1,3-双极性有机化合物 - 吡嗪甲酰胺 - 乙烯酰胺 |
| 描述（Description） | 该化合物属于吡嗪羧酰胺类有机化合物。这类化合物含有吡嗪环，其上连接有羧酰胺基团。 |
| 外部描述符（External Descriptors） | 暂无 |
三维结构
交互式化学结构模型
关联靶点（人）
SLC9A1
Tchem
钠/氢交换器 1(Sodium/hydrogen exchanger 1)
(1 活性数据)
SLC9A5
Tchem
钠/氢交换器 5(Sodium/hydrogen exchanger 5)
(6 活性数据)
PKD2L1
Tchem
多囊肾病 2 类蛋白 1(Polycystic kidney disease 2-like 1 protein)
(1 活性数据)
ADRA2A
Tclin
α-2A 肾上腺素受体(Alpha-2A adrenergic receptor)
(1 活性数据)
ASIC1
Tchem
酸敏感离子通道 1(Acid-sensing ion channel 1)
(1 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
TSHR
Tclin
Thyroid stimulating hormone receptor
(29986 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
HTR5A
Tchem
Serotonin 5a (5-HT5a) receptor
(1433 活性数据)
ARSA
Tbio
Cerebroside-sulfatase
(655 活性数据)
ALOX15B
Tchem
Arachidonate 15-lipoxygenase, type II
(7244 活性数据)
CYP2D6
Tclin
Cytochrome P450 2D6
(33882 活性数据)
SMPD1
Tchem
Sphingomyelin phosphodiesterase
(13561 活性数据)
GLP1R
Tclin
Glucagon-like peptide 1 receptor
(111429 活性数据)
SLC9A3
Tclin
Sodium/hydrogen exchanger 3
(483 活性数据)
SLC9A5
Tchem
Sodium/hydrogen exchanger 5
(22 活性数据)
CYP1A2
Tchem
Cytochrome P450 1A2
(26471 活性数据)
CYP2C9
Tchem
Cytochrome P450 2C9
(32119 活性数据)
CYP2C19
Tchem
Cytochrome P450 2C19
(29246 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
HEK293
(82097 活性数据)
FEN1
Tchem
Flap endonuclease 1
(12055 活性数据)
POLI
Tchem
DNA polymerase iota
(116820 活性数据)
TDP1
Tchem
Tyrosyl-DNA phosphodiesterase 1
(345557 活性数据)
THPO
Tbio
Thrombopoietin
(834 活性数据)
GMNN
Tbio
Geminin
(128009 活性数据)
PMP22
Tbio
Peripheral myelin protein 22
(699 活性数据)
MBNL1
Tbio
Muscleblind-like protein 1
(34431 活性数据)
CBX1
Tbio
Chromobox protein homolog 1
(92434 活性数据)
MPHOSPH8
Tbio
M-phase phosphoprotein 8
(656 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
ATXN2
Tbio
Ataxin-2
(54410 活性数据)
USP1
Tchem
Ubiquitin carboxyl-terminal hydrolase 1
(22556 活性数据)
RGS4
Tchem
Regulator of G-protein signaling 4
(13867 活性数据)
MEN1
Tchem
Menin/Histone-lysine N-methyltransferase MLL
(48157 活性数据)
OPRD1
Tclin
Opioid receptors; mu & delta
(1530 活性数据)
PAX8
Tchem
Paired box protein Pax-8
(1910 活性数据)
关联靶点（其它种属）
SLC9A1
Sodium/hydrogen exchanger 1 (3 活性数据)
SLC9A2
Sodium/hydrogen exchanger 2 (9 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Saccharomyces cerevisiae (19171 活性数据)
Plasmodium falciparum (966862 活性数据)
NHE1
Sodium/hydrogen exchanger (7 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Txnrd1
Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
FTL
Ferritin light chain (43324 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
溶于DMSO, 最高浓度 (mg/mL): 29.98, 最高浓度(mM): 100；溶于1eq. HCl, 最高浓度 (mg/mL): 14.99, 最高浓度(mM): 50
分子量
299.760 g/mol
XLogP3
1.300
氢键供体数Hydrogen Bond Donor Count
3
氢键受体数Hydrogen Bond Acceptor Count
5
可旋转键计数Rotatable Bond Count
4
精确质量Exact Mass
299.126 Da
单同位素质量Monoisotopic Mass
299.126 Da
拓扑极表面积Topological Polar Surface Area
137.000 Ų
重原子数Heavy Atom Count
20
形式电荷Formal Charge
0
复杂度Complexity
372.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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技术文档和文章
此产品的引用文献
引用文献
| 1. Xucan Yang, Lulu Cheng, Yile Zhao, Haoran Ma, Haitao Song, Xuanmin Yang, Kang-Nan Wang, Yanrong Zhang. (2023) Aggregation-induced emission-active iridium (III)-based mitochondria-targeting nanoparticle for two-photon imaging-guided photodynamic therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:38176241] [10.1016/j.jcis.2023.12.172] |
| 2. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao. (2023) Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways. FOOD CHEMISTRY, [PMID:37897825] [10.1016/j.foodchem.2023.137771] |
| 3. Xin Chang, Chang Liu, Yu-Mo Han, Qiu-Ling Li, Bin Guo, Hu-Lin Jiang. (2023) Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion. Molecular Therapy-Nucleic Acids, [PMID:37159604] [10.1016/j.omtn.2023.04.006] |
| 4. Wu Wenting, Ding Quan, Zhou Zhiwei, Kuang Wenliang, Jiang Lipeng, Liu Peng, Ai Weiping, Zhu Weifeng. (2023) Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios. AAPS PHARMSCITECH, 24 (2): (1-16). [PMID:36792796] [10.1208/s12249-022-02454-y] |
| 5. Hou Zhenyu, Zhou Mei, Ma Yuanyuan, Xu Xiaoxuan, Zhang Zhiqi, Lai Shiwei, Fan Wenpei, Xie Jinbing, Ju Shenghong. (2022) Size-changeable nanoprobes for the combined radiotherapy and photodynamic therapy of tumor. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 49 (8): (2655-2667). [PMID:35536421] [10.1007/s00259-022-05830-9] |
| 6. Xiudan Wang, Junya Lu, Yuling Mao, Qinfu Zhao, Caishun Chen, Jianan Han, Meiqi Han, Huijuan Yuan, Siling Wang. (2022) A mutually beneficial macrophages-mediated delivery system realizing photo/immune therapy. JOURNAL OF CONTROLLED RELEASE, [PMID:35489548] [10.1016/j.jconrel.2022.04.038] |
| 7. Mingming Song, Shuqi Dong, Xiaofei An, Wenxiang Zhang, Ning Shen, Yanbo Li, Caixia Guo, Chang Liu, Xiao Li, Siyu Chen. (2022) Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers. JOURNAL OF CONTROLLED RELEASE, [PMID:35381274] [10.1016/j.jconrel.2022.03.060] |
| 8. Min Li, Sanpeng Li, Yixuan Huang, Haixia Chen, Songya Zhang, Zhicheng Zhang, Weigang Wu, Xiaobin Zeng, Boping Zhou, Bin Li. (2021) Secreted Expression of mRNA-Encoded Truncated ACE2 Variants for SARS-CoV-2 via Lipid-Like Nanoassemblies. ADVANCED MATERIALS, 33 (34): (2101707). [PMID:34278613] [10.1002/adma.202101707] |
| 9. Yu Zhang, Junxi Liu, Pengfei Dou, Zhijing Wu, Ziming Zheng, Xianglin Pan, Tao Zhou, Kaiping Wang. (2021) Oral absorption characteristics and mechanisms of a pectin-type polysaccharide from Smilax china L. across the intestinal epithelium. CARBOHYDRATE POLYMERS, [PMID:34364625] [10.1016/j.carbpol.2021.118383] |
| 10. Zhuqing Dai, Jiangfeng Song, Ye Chen, Lei Feng, Yayuan Xu, Dajing Li, Caie Wu, Zhongyuan Zhang, Jun Liu. (2021) Study on the bioavailability of stevioside-encapsulized lutein and its mechanism. FOOD CHEMISTRY, [PMID:33756320] [10.1016/j.foodchem.2021.129528] |
| 11. Guo Shiqi, Liang Yanzi, Liu Lanze, Yin Miaomiao, Wang Aiping, Sun Kaoxiang, Li Youxin, Shi Yanan. (2021) Research on the fate of polymeric nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size, surface charge and pro-hydrophobics. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-21). [PMID:33499885] [10.1186/s12951-021-00770-2] |
| 12. Hu Gaowei, Miao Yingjie, Luo Xi, Chu Wenhui, Fu Yongqian. (2020) Identification of a novel cell-penetrating peptide derived from the capsid protein of chicken anemia virus and its application in gene delivery. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (24): (10503-10513). [PMID:33141296] [10.1007/s00253-020-10988-z] |
| 13. Xinyi Tan, Na Yin, Zixu Liu, Rong Sun, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Xing Tang. (2020) Hydrophilic and Electroneutral Nanoparticles to Overcome Mucus Trapping and Enhance Oral Delivery of Insulin. MOLECULAR PHARMACEUTICS, [PMID:32697099] [10.1021/acs.molpharmaceut.0c00223] |
| 14. Yajun Liu, Rui Dai, Qiuyu Wei, Wenzhe Li, Guang Zhu, Hao Chi, Zhaoming Guo, Li Wang, Changhao Cui, Jianqiang Xu, Kun Ma. (2019) Dual-Functionalized Janus Mesoporous Silica Nanoparticles with Active Targeting and Charge Reversal for Synergistic Tumor-Targeting Therapy. ACS Applied Materials & Interfaces, [PMID:31682097] [10.1021/acsami.9b15434] |
| 15. Hu Gaowei, Zheng Wenlv, Li Ao, Mu Yaru, Shi Mingyu, Li Tuofan, Zou Haitao, Shao Hongxia, Qin Aijian, Ye Jianqiang. (2018) A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis. VETERINARY RESEARCH, 49 (1): (1-9). [PMID:29439726] [10.1186/s13567-018-0513-2] |
| 16. Liu Di, Guo Hua, Zheng Wenyun, Zhang Na, Wang Tianwen, Wang Ping, Ma Xingyuan. (2016) Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 100 (11): (5079-5088). [PMID:26960316] [10.1007/s00253-016-7423-x] |
| 17. Dan Li, Gaoyang Yi, Guifang Cao, Adam C. Midgley, Yongli Yang, Dan Yang, Wenguang Liu, Yujuan He, Xiaolin Yao, Guoliang Li. (2025) Dual-Carriers of Tartary Buckwheat-Derived Exosome-Like Nanovesicles Synergistically Regulate Glucose Metabolism in the Intestine-Liver Axis. Small, [PMID:40079102] [10.1002/smll.202410124] |
| 18. Xiao-Lin Hou, Bin Zhang, Kai Cheng, Fang Zhang, Xiao-Ting Xie, Wei Chen, Lin-Fang Tan, Jin-Xuan Fan, Bo Liu, Qiu-Ran Xu. (2024) Engineering Phage Nanocarriers Integrated with Bio-Intelligent Plasmids for Personalized and Tunable Enzyme Delivery to Enhance Chemodynamic Therapy. Advanced Science, [PMID:38582522] [10.1002/advs.202308349] |
| 19. Junxi Liu, Xiaoke Zhang, Yan Liu, Zhijing Wu, Zheng Cui, Xianglin Pan, Yuheng Zheng, Jinglin Wang, Kaiping Wang, Yu Zhang. (2024) Intestinal lymphatic transport of Smilax china L. pectic polysaccharide via Peyer's patches and its uptake and transport mechanisms in mononuclear phagocytes. CARBOHYDRATE POLYMERS, [PMID:38823922] [10.1016/j.carbpol.2024.122256] |
| 20. Yadan Zhang, Xiaoyu Zhang, Tianhan Kai, Lin Zhang, Anping Li. (2024) Lycium ruthenicum Murray derived exosome-like nanovesicles inhibit Aβ-induced apoptosis in PC12 cells via MAPK and PI3K/AKT signaling pathways. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39089544] [10.1016/j.ijbiomac.2024.134309] |
| 21. Dan Yuan, Zhicheng Niu, Wenyu Zheng, Qiangzhong Zhao, Feibai Zhou, Mouming Zhao. (2024) Mind the Particle Rigidity: Blooms the Bioavailability via Rapidly Crossing the Mucus Layer and Alters the Intracellular Fate of Curcumin. ACS Nano, [PMID:39297569] [10.1021/acsnano.4c09838] |
| 22. Xiao-Lin Hou, Lin-Fang Tan, Xiao-Ting Xie, Bin Zhang, Qiong Wang, Kai Cheng, Jin-Xuan Fan, Tian-Cai Liu, Bo Liu. (2024) Peroxisome-inspired T4 phage hybrid enzyme nanoreactors for photodynamic therapy of breast cancer. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2024.159138] |
| 23. Dan Yang, Yuqi Feng, Ying Yuan, Linxuan Zhang, Yao Zhou, Adam C. Midgley, Yanrong Wang, Ning Liu, Guoliang Li, Xiaolin Yao, Dechun Liu. (2024) Protein Coronas Derived from Mucus Act as Both Spear and Shield to Regulate Transferrin Functionalized Nanoparticle Transcellular Transport in Enterocytes. ACS Nano, [PMID:38417159] [10.1021/acsnano.3c11315] |
| 24. Wu Can, Zhang Xiao Wei, Wang Manman, Sun Jinpan, Chen Jianfei, Guan Yanbin, Pang Xin. (2025) Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer. JOURNAL OF NANOBIOTECHNOLOGY, 23 (1): (1-20). [PMID:39891144] [10.1186/s12951-025-03143-1] |
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常见问题
本产品的纯度是多少？
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本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1154-25-2，分子式为 C11H18ClN7O，分子量为 299.76 g/mol。InChIKey QDERNBXNXJCIQK-UHFFFAOYSA-N。
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