Transferrin is a monomeric glycoprotein found in plasma at an average concentration of 250 mg/100 ml. The specific iron-binding protein in plasma, it has a role in the transportation and distribution of iron among the body organs, in iron metabolism and prevention of iron loss via the kidneys. Stored in bone marrow as Tf-bound iron, it also possesses bacteriostatic and fungistatic activity. Clinically, decreases in transferrin are observed in congenital disorders, newborns, inflammatory diseases, hypoproteinemias and nephrotic syndrome; increases are found in pregnancy, iron-deficiency anemias, and inoculation hepatitis. Transferrin is required by all types of cells in cultures for maximal growth. It is, therefore, an important transport factor used in defined culture media.

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Purity: ≥95% by SDS PAGE

Iron Content: >1μg iron/mg protein

Endotoxin level: <0.1 EU/mg by LAL testing

规格

产品名称

转铁蛋白 (HOLO) 来源于人血浆

英文别名

Serotransferrin | TF | TFQTL1

规格或纯度

BioReagent,天然,低内毒素,组织培养级,PBS Only,≥95%(SDS-PAGE),铁含量：>1μg/mg ; 冻干前浓度：见COA

生化机理

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use. (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use.

种属

人(Human)

来源

天然

预测分子量

80 kDa

CAS编号和信息

11096-37-0

分子类型

蛋白质

产品线

生物产品

储存与运输

物理形态

冻干(Lyophilized)

储存缓冲液

Lyophilized from 20 mM Na Phosphate, 150 mM NaCl, pH 7.4.

浓度

铁含量：>1μg/mg ; 冻干前浓度：见COA

复溶

After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.

储存条件

-20°C储存,避免反复冻融

运输条件

超低温运输

稳定性与储存

长期储存-20℃（＞1年）；复溶后建议分装，避免反复冻融。

高级数据

产品属性

ALogP	-2.5

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C of A & Other Certificates(BSE/TSE, COO):

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找到2个结果

批号(Lot Number)	证书类型	货号
ZJ26F0232269	分析证书	np001013
ZJ26F0232268	分析证书	np001013

技术文档和文章

np001013_transferrin holo from human plasma.pdf

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Professional Guide to Streptavidin-Modified Proteins

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蛋白质分子量标准

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蛋白质蛋白质分子量标准

Protein Molecular Weight Standards

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protein Protein Molecular Weight Standards

转铁蛋白与脱铁转铁蛋白：结构特征、铁稳态机制与应用技术要点

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细胞培养转铁蛋白脱铁转铁蛋白铁饱和度转铁蛋白受体受体介导内吞靶向递送

Transferrin and Apo-Transferrin: Structural Features, Iron-Homeostasis Mechanisms, and Key Technical Application Points

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cell culture Transferrin apo-transferrin transferrin saturation transferrin receptor receptor-mediated endocytosis targeted delivery

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Functional Systems of Plasma Proteins in Metal Transport, Inflammatory Responses, and Tissue Injury

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Urinary Protein Biomarker Analysis in Kidney Injury: Detection Significance of Albumin, Transferrin, IgG, and α2-Macroglobulin

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