Lactoferrin along with Secretory IgA can have a bacteriostatic effect in the intestinal tract of a breast fed newborn. Lactoferrin may also function as a promoter of iron absorption due to the high bioavailability of iron from digested Lactoferrin.
Prepared from human milk shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.
Post-translational: Isoform DeltaLf: Phosphorylation at Ser-10 activates the transcriptional activity. Phosphorylation at Ser-10 also promotes proteasomal degradation. Alternatively can undergo O-GlcNAcylation at Ser-10. Isoform DeltaLf: O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates the transcriptional activity. Alternatively can undergo phosphorylation at Ser-10 (PubMed:20404350). Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.
种属
人(Human)
来源
天然
预测分子量
82.4 kDa
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 50 mM Tris-HCl, 0.2 M NaCl, pH 8.0.
浓度
冻干前浓度：见COA
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
ZJ26F0333366
危险品化学品经营许可证（带存储）