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低分子量激肽原(LMWK)属于一类血浆蛋白;该类蛋白被激肽释放酶切割后释放缓激肽,进而参与血压调控、炎症反应与痛觉介导。
蛋白生物学功能
低分子量激肽原(LMWK)是由KNG1基因可变剪接产生的血浆蛋白,含 427 个氨基酸。与高分子量激肽原不同,LMWK 不直接参与凝血过程,但在血压调节与血管稳态维持中发挥重要作用。它是组织激肽释放酶的内源性底物;组织激肽释放酶可切割 LMWK,释放赖氨酰缓激肽(凯力丁)—— 一种血管活性肽,该肽还可进一步转化为缓激肽。二者均可诱导血管舒张、增加血管通透性,从而调控血压与炎症应答。
常见研究用途
此外,LMWK 是重要的胞外半胱氨酸蛋白酶抑制剂,可调控组织内蛋白酶活性,防止蛋白过度水解。激肽原水平异常或功能缺陷与炎症、糖尿病、心肌梗死及部分肿瘤等疾病相关。LMWK 及其酶切产物也被研究作为心血管疾病与炎症疾病潜在生物标志物和药物靶点。
常见应用方向:心血管研究、酶活与抑制实验、药物研发、体外诊断(IVD)检测标准品、校准品与质控品。
Kininogen, Low Molecular Weight (LMW) is a family of plasma proteins which mediate blood pressure, inflammation, and pain when cleaved by kallikrein to release bradykinin.
Role of protein in biology
Low Molecular Weight Kininogen (LMWK) is a plasma protein produced through alternative splicing of the KNG1 gene and consists of 427 amino acids. Unlike its high molecular weight counterpart, LMWK is not directly involved in blood coagulation but plays a key role in blood pressure regulation and vascular homeostasis. It serves as an endogenous substrate for tissue kallikrein, which cleaves LMWK to release kallidin-a vasoactive peptide that can be further converted to bradykinin-both of which induce vasodilation and increase vascular permeability, thereby influencing blood pressure and inflammatory responses.
Common research uses
Additionally, LMWK acts as a major extracellular cysteine protease inhibitor, helping regulate protease activity in tissues and contributing to protection against excessive proteolysis. Altered levels or dysfunction of kininogens have been associated with conditions such as inflammation, diabetes, myocardial infarction, and certain cancers. LMWK and its cleavage products are also being explored as potential biomarkers and therapeutic targets in cardiovascular and inflammatory diseases.
Common uses include cardiovascular research, enzymatic and inhibition assays, therapeutics research, IVD Assay standards, calibrators and controls.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | np001046 | |
| 分析证书 | np001046 |