Bactericidal Permeability-increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.
规格
产品名称
杀菌性通透性增加蛋白 (BPI) 来源于人中性粒细胞
别名
细菌/渗透性增加蛋白 | 杀菌性/通透性增加蛋白 | 杀菌/渗透性促进蛋白
英文别名
Bacterial/Permeability-Increasing Protein | BPI | CAP57 | rBPI | BPIFD1
规格或纯度
BioReagent, 天然, ≥95%(SDS-PAGE), 见COA
生化机理
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
ZJ25F1129316
危险品化学品经营许可证（带存储）