计算溶液所需的质量、体积或浓度。
谷氨酸型纤溶酶原
有货
为什么选择此级别
BioReagent,天然 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Purified from fresh frozen human plasma. Plasminogen is activated to the serine protease plasmin via urokinase, streptokinase or tissue plasminogen activator.
The Human glu-plasminogen is homogeneous on SDS-PAGE gels and shows no reduction upon incubation with 2-mercaptoethanol. No Plasmin activity was detected using the chromogenic substrate S-2251.
Extinction Coefficient (1%) = 17.0
The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
规格
产品名称
谷氨酸型纤溶酶原
别名
纤溶酶原，Glu型，来源于人血浆
英文别名
Plasminogen, Glu-Type, Human Plasma | Human Glu-Plasminogen | Glu-Plasminogen from Human plasma | Human glu-Plasminogen Native Protein | PLG | HAE4
规格或纯度
BioReagent, 天然, 来源于人血浆; 冻干前浓度：见COA
生化机理
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete. The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut. (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. (Microbial infection) Interacts with dengue virus type 2 particles. Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes.
Post-translational: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide. (Microbial infection) The Y.pestis Pla protein cleaves between Arg-580 and Val-581, generating plasmin which facilitates bacterial migration and infection.
生物活性
见COA
种属
人(Human)
来源
天然
预测分子量
90 kDa
CAS编号和信息
9001-91-6
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 50mM Tris-HCl, 0.1 M NaCl, pH 7.4.
浓度
来源于人血浆; 冻干前浓度：见COA
复溶
We suggest hydrating the protein with a good quality water to the original volume (See COA). After hydration aliquot into a useful (one time use) size and freeze at -80℃.
储存条件
2-8°C储存
运输条件
低温运输
稳定性与储存
长期储存2-8℃；复溶后建议分装，于-80℃冷冻保存。
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ26F0939222 |
分析证书 | np330965 |
| ZJ26F0939178 |
分析证书 | np330965 |
| ZJ26F0737112 |
分析证书 | np330965 |
| ZJ26F0737111 |
分析证书 | np330965 |
技术文档和文章
Dynamic Remodeling of the Coagulation-Anticoagulation Protein Network in Cardiovascular Diseases and Its Research Framework
目录： 技术文章
Mechanisms of Action, Functional Differences, and Thrombolytic Applications of Fibrinolytic System Activators
目录： 技术文章
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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