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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
CCL28属于CC家族趋化因子，又称粘膜相关上皮趋化因子(MEC)。CCL28 cDNA位于人的chr5上，CCL28的mRNA在人和小鼠的正常和病理结肠， 唾液腺，乳腺，气管和直肠等不同组织的上皮细胞中高度表达。人和小鼠的CCL28氨基酸序列在蛋白质被加工成成熟形态时，具有83%的同源性。CCL28是通过CCR3和CCR10信号转导，以及静息CD4、CD8 t细胞和嗜酸性粒细胞的趋化。MEC/ CCL28含有6个半胱氨酸，包括4个高度保守的半胱氨酸残基CC趋化因子。重组人MEC/ CCL28蛋白为12.3kDa，含有108个氨基酸残基；
Purity
>96% SDS-PAGE. estimated also by HPLC.Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Function
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
CCL28 belongs to CC family chemokine, also named mucosae-associated epithelial chemokine (MEC). The CCL28 cDNA is located on Chr.5 in humans, and the mRNA of CCL28 is highly expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. The amino acids sequence of human and mouse CCL28 shares 83 % identity, when the protein is processed to be the mature form. CCL28 is signaling through CCR3 and CCR10, and chemotactic for resting CD4, CD8 T-cells and eosinophils. MEC/ CCL28 contains six cysteines, including the four highly conserved cysteine residues present in CC chemokines. Recombinant Human MEC/ CCL28 is a 12.3kDa protein containing 108 amino acid residues..
Recombinant Human CCL28 Protein (rp143745) - Protein Bioactivity
Fully biologically active when compared to standard. Determined by its ability to chemoattract human lymphocytes using a concentration range of 1.0-10.0 ng/mL.
Recombinant Human CCL28 Protein (rp143745) - SDS-PAGE
2.5 μg/lane of Recombinant Human CCL28 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 12.9 kDa under reducing conditions and 22.2 kDa under non-reducing conditions.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ23F0600388 |
分析证书 | rp143745 |
| ZJ23F0600389 |
分析证书 | rp143745 |
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