Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC. The specific activity is >1300 pmol/min/µg, as measured under the described conditions.
Function Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC. The specific activity is >1300 pmol/min/µg, as measured under the described conditions.
10 & 25 kDa, under reducing conditions; 25 - 30 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human Kallikrein 6 Protein (rp147935) - SDS-PAGE 3 μg/lane of Recombinant Human Kallikrein 6 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 10 & 25 kDa (autolysis 80 - 81AA) under reducing conditions and 25 - 30 kDa under non-reducing conditions. Kallikrein 6 belongs to the serine protease family, and its activity is dependent on the active site formed by the catalytic triad (His57, Asp102, Ser195). Arg-80 is located in an accessible region on the enzyme surface (such as a flexible loop or near the substrate-binding domain), making this site susceptible to autolytic attack by its own catalytic activity (PMID: 11983703).
ZJ24F1215568
危险品化学品经营许可证（带存储）