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Recombinant Human FGF-9 Protein

货号: rp181240
COA
有货
级别和纯度: 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 高性能 ? 高性能级 —— 纯度和性能特性经过优化。适用于普通等级无法满足的灵敏分析。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 ≥95%(SDS-PAGE) 见COA
Accession #
P31371
蛋白标签
N-His
表达系统
E. coli
内毒素水平
<1.0 EU/μg
生物活性
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.36 ng/mL.
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规格
库存
价格
数量
10μg
rp181240-10μg
现货 Stock Image
¥799.90
50μg
rp181240-50μg
现货 Stock Image
¥2,399.90
100μg
rp181240-100μg
现货 Stock Image
¥3,799.90
1mg
rp181240-1mg
期货 Stock Image
¥13,679.90
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大包装 / 定制
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SDS
安全数据
COA
分析证书
Data Sheet
产品数据
Spec Sheet
规格说明
大包装询价 收藏夹
Recombinant Human FGF-9 Protein
规格 储存与运输 图片 技术文档 高级数据 质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章 溶液计算器
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为什么选择此级别

ActiBioPure™,His标签,无载体,生物活性,高性能 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

规格

产品名称
Recombinant Human FGF-9 Protein
别名
重组人FGF-9蛋白 | 重组人成纤维细胞生长因子9蛋白
英文别名
FGF9 | FGF-9 | fibroblast growth factor 9 (glia-activating factor) | Fibroblast growth factor 9 | GAF | glia-activating factor | HBFG-9 | HBGF-9 | Heparin-binding growth factor 9 | MGC119914 | MGC119915 | SYNS3
规格或纯度
无载体,生物活性,ActiBioPure™,高性能,His标签,≥95%(SDS-PAGE),见COA
生化机理
Fibroblast growth factor 9 (FGF-9), also known as HBGF9 and GAF, is a member of the FGF family of secreted glycoproteins involved in mammalian skeleton morphogenesis and growth. The FGF family is characterized by a core heparin-binding FGF domain of approximately 120 amino acids (aa) that exhibits a beta-trefoil structure. Mature mouse FGF-9 shares 99% and 100% aa sequence identity with human and rat FGF-9, respectively. FGF-9, along with FGF-16 and -20, form an FGF subfamily that shares 65-71% aa sequence identity, binds FGFR3(IIIb), and is efficiently secreted despite having an uncleavable, bipartite signal sequence. In addition to FGFR3(IIIb), FGF-9 binding to the IIIc splice forms of FGFR-1, -2, and -3 has been reported. In the mouse embryo, the location and timing of FGF-9 expression affects the development of the skeleton, cerebellum, lungs, heart, vasculature, digestive tract, and testes. Deletion of mouse FGF-9 is lethal at birth due to lung hypoplasia and causes rhizomelia, or shortening of the proximal skeleton. Additionally, a mutation in mouse FGF-9 is responsible for Elbow knee synostosis (Eks), which causes joint fusions in the elbow and knee. In humans, FGF9 mutations that lower receptor binding can result in multiple synostoses syndrome (SYNS). Altered FGF-9 expression or function is reported in human colon, endometrial, and ovarian cancers, correlating with progression, invasiveness, and survival. Post-translational: Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step. N-glycosylated.
生物活性
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.36 ng/mL.
表达系统
E. coli
种属
人(Human)
氨基酸
3-208 aa
序列
MHHHHHHPLGEVGNYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS
蛋白标签
N-His
无载体
Yes
无动物源
No
来源
重组表达
预测分子量
24.2 kDa
SDS-PAGE
25.5 kDa, under reducing conditions; 23.9 & 25.8 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 150mM NaCl, 5% Trehalose, 1mM EDTA, 20% Glycerol, 1mM DTT, pH 8.5.
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片

Recombinant Human FGF-9 Protein (rp181240) - Bioactivity
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.36 ng/mL.

Recombinant Human FGF-9 Protein (rp181240) - SDS-PAGE
2 μg/lane of Recombinant Human FGF-9 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 25.5 kDa under reducing conditions and 23.9 & 25.8 kDa under non-reducing conditions.
The two N bands of FGF-9 should be its two different conformations. The unique N and C termini of FGF9 subfamily ligands mediate reversible homodimerization, and it is speculated that the interaction between these two conformations will form dimerization (PMID: 11060292).

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

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✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number) 证书类型 货号
ZJ25F0320005 分析证书 rp181240
ZJ25F0320006 分析证书 rp181240
ZJ25F0320007 分析证书 rp181240
技术文档和文章
FGF通路的配体体系、受体激活与生物学效应
目录： 技术文章
探索主题:
FGF PI3K-AKT 发育信号通路 FGFR 成纤维细胞生长因子受体 Klotho RAS-MAPK PLCγ
Ligand Systems, Receptor Activation, and Biological Effects of the FGF Pathway
目录： 技术文章
探索主题:
FGF PI3K-AKT Developmental signaling pathway FGFR Klotho RAS-MAPK PLCγ fibroblast growth factor receptor
溶液计算器
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