Recombinant Mouse CXCL17/VCC-1 Protein

无载体

≥90%(SDS-PAGE)
见COA

功能和特点

表达系统: E. coli
Accession #: Q5UW37
蛋白标签: N-His
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp184867-10μg	10μg	期货
rp184867-50μg	50μg	期货
rp184867-100μg	100μg	期货
rp184867-1mg	1mg	期货

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点击查看蛋白信息: CXCL17

Accession#: Q5UW37 (1) CXCL17 (1) CXCL17/VCC-1 (1) Gene ID: 232983 (1)

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基本描述

产品名称	Recombinant Mouse CXCL17/VCC-1 Protein
规格或纯度	无载体, ≥90%(SDS-PAGE), 见COA
生化机理	Dendritic cell and monocyte chemokine-like protein (DMC), also known as VEGF-correlated chemokine-1 (VCC-1), is a secreted molecule with a size and predicted three-dimensional folding pattern similar to that of chemokines CXCL8/IL-8 and CXCL14/BRAK. It has no predicted N-glycosylation sites, so cleavage of a 22 amino acid (aa) signal sequence likely results in a mature mouse DMC molecule of 97 aa and 11 kDa size. DMC is constitutively produced by airway and intestinal epithelium. It induces the chemotaxis of quiescent, but not LPS‑activated peripheral blood monocytes and dendritic cells, and also binds these cells specifically (1). DMC expression is increased in endothelial cells when they are induced to form tubes in vitro. Transgenic overexpression in NIH3T3 cells causes up‑regulation of proteins such as VEGF and FGF basic, and increases cell growth rate and tumorigenicity. DMC and two other chemokines that play roles in angiogenesis, CXCL1/GRO and CXCL8/IL-8, show significantly correlated expression with that of VEGF in primary lung, breast and esophageal tumors. DMC is therefore suggested to play a role in tumor angiogenesis. Mature mouse DMC shares 82%, 71% and 66% amino acid sequence identity with rat, human and bovine DMC, respectively. Post-translational: Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	小鼠(Mouse)
氨基酸	23-119 aa
序列	MGSSHHHHHHSSGENLYFQ/SPNPGVARSHGDQHLAPRRWLLEGGQECECKDWFLQAPKRKATAVLGPPRKQCPCDHVKGREKKNRHQKHHRKSQRPSRACQQFLKRCHLASFALPL
蛋白标签	N-His
无载体	Yes
无动物源	No
Accession #	Q5UW37
来源	重组表达
预测分子量	13.4 kDa
SDS-PAGE	10.1-18.1 kDa, under reducing conditions; 10.0-18.6 kDa, under non-reducing conditions.

图片

SDS-PAGE: Recombinant Mouse CXCL17/VCC-1 Protein (rp184867)

Recombinant Mouse CXCL17/VCC-1 Protein (rp184867) - SDS-PAGE
2 μg/lane of Recombinant Mouse CXCL17/VCC-1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 10.1-18.1 kDa under reducing conditions and 10.0-18.6 & 26.0-30.8 kDa under non-reducing conditions.
The observation of CXCL17/VCC-1 Protein as both dimers and monomers under non-reducing (NR) conditions suggests that a portion of the protein forms dimers. This dimerization may be mediated by (or stabilized by) disulfide bonds (Uniprot: Q5UW37).

产品规格参数

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4.
浓度	见COA
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	-20℃保存 6个月；复溶后建议分装，避免反复冻融。
分子类型	蛋白质

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Recombinant Mouse CXCL17/VCC-1 Protein

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基本描述

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产品规格参数

安全和危险性（GHS）

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