BPTP3 | CFC | JMML | METCDS | MGC14433 | NS1 | OTTHUMP00000166107 | OTTHUMP00000166108 | Protein tyrosine phosphatase 2 | Protein tyrosine phosphatase 2C | Protein tyrosine phosphatase non receptor type 11 | Protein-tyrosine phosphatase 1D | Protein-tyros
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),见COA
生化机理
Src-Homology domain-2 containing protein tyrosine Phosphatase 2 (SHP-2), also called protein tyrosine phosphatase, non-receptor type 11 (PTPN11), PTP1D, PTP2C, and SYP, is an enzyme that dephosphorylates tyrosine residues in proteins. The protein contains two Src homology 2 (SH2) domains, which both regulate the activity of the enzyme and allow it to selectively bind to SH2 sites on proteins such as Dok1, IRS1, and the insulin receptor. SHP-2 plays a unique stimulatory role in cell signaling. Cells lacking SHP-2 have poor mobility because the hyper-phosphorylation of FAK and other proteins in the focal adhesion complex prevents turnover of cellular attachment points. Without SHP-2, sustained ERK stimulation does not take place. The Y992 phosphorylation site of EGFR is a particularly good substrate for SHP-2 and a phosphopeptide containing this sequence can be used to measure the activity of the enzyme (Catalog # ES006) by detecting release of phosphate (Catalog # DY996). Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
Post-translational: Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human SHP-2 Protein (rp184964) - SDS-PAGE 3 μg/lane of Recombinant Human SHP-2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 62.2 kDa.
ZJ24F1113675
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