Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
19.6 kDa, under reducing conditions; 18.3 & 36.0 & 53.7 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
20mM Tris, 500mM NaCl, 5% Glycerol, pH 8.0
浓度
见COA
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃ 存储6个月；收货后建议分装，避免反复冻融。
图片
Recombinant Human Glutathione Peroxidase 4 Protein (rp220388) - SDS-PAGE 3 μg/lane of Recombinant Human Glutathione Peroxidase 4 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 19.6 kDa under reducing conditions and 18.3 & 36.0 & 53.7 kDa under non-reducing conditions. The 30-197 amino acid fragment of the GPX4 protein may lack native structural domains, leading to exposure of hydrophobic regions and consequently increasing aggregation propensity. Additionally, substitution of selenocysteine (Sec) with cysteine (Cys) at position 73 (U73C) may enable the introduced Cys residue to form non-native disulfide bonds with adjacent cysteine residues, triggering intermolecular crosslinking and resulting in the formation of dimers or multimers (Uniprot ID: P36969).
危险品化学品经营许可证（带存储）