Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba^{2+^{(1 mM), H₂O₂ (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM). Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants.}}

In vivo

Triamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos. Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Triamcinolone Acetonide

生化机理

曲安奈德是一种人工合成的糖皮质激素，用于炎症的对症治疗。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

激动剂

作用机制

糖皮质激素受体激动剂

名称和识别符

EC号

200-948-7

分子类型

小分子

Isomeric SMILES

C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O

PubChem CID

6436

分子量

434.50

高级数据

产品属性

ALogP	2.5

关联靶点（人）

NR3C1 Tclin 糖皮质激素受体(Glucocorticoid receptor) (3 活性数据)

点击查看靶蛋白信息： NR3C1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

敏感性

对光敏感

熔点

274-278℃

安全和危险性（GHS）

信号词

危险

危险声明

H360: 可能对生育能力或胎儿造成伤害

WGK Germany

RTECS

TU3920000

Merck Index

9596

个人防护装备

Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

糖皮质激素（GCs）与受体GR：作用机制、分类框架与最新进展（附产品选型表）

目录：技术文章

探索主题:

糖皮质激素 GCs 受体GR GR

Glucocorticoids (GCs) and the Glucocorticoid Receptor (GR): Mechanisms, Classification Frameworks, and the Latest Advances (with a Product Selection Table)

目录：技术文章

探索主题:

GCs GR Glucocorticoids Glucocorticoid Receptor (GR)