Name: 硫酸长春新碱, 微管蛋白抑制剂
SKU: V408259
Availability: InStock

硫酸长春新碱, 微管蛋白抑制剂

CAS: 2068-78-2 货号: V408259 分子式: C₄₆H₅₆N₄O₁₀·H₂SO₄ 分子量: 923.04 Beilstein号: 3924631 EC号: 218-190-0

概述规格名称和识别符技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 化学和物理性质安全和危险性（GHS）此产品的引用文献技术文档和文章溶液计算器

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为什么选择此级别

，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-80℃储存。特低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 11 篇同行评审文献引用。

概述

水溶性:＞=1 g/100 mL at 24℃

Information

Vincristine (NSC-67574) sulfate Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay. Vincristine sulfate induce
In vitro

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with K_i of 85 nM. At low concentrations, Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration.

In vivo

Vincristine (3 mg/kg) administrated by a single i.p. injection to mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, induces mean growth delay of >120 and >52 day, and repopulating fractions of 0.06% and 5%, respectively. Vincristine acts on subcutaneous colon 38 tumors in mice by host cell-mediated vascular effects as well as by direct tubulin-mediated cytotoxicity. Vincristine (5 mg/kg) reduces tumor blood flow of tumors by nearly 75% .
Cell Data

cell lines：

Concentrations：10 nM

Incubation Time：3 days

Powder Purity:≥98%

规格

英文别名

Leurocristine, Oncovin, 22-Oxovincaleukoblastine | 22-oxo-vincaleukoblastine, sulfate (1:1)

规格或纯度

10mM in DMSO

英文名称

Vincristine (NSC-67574) sulfate

生化机理

硫酸长春新碱（NSC-67574，Leurocristine，Oncovin，22-Oxovincaleukoblastine）是一种通过与微管蛋白结合来抑制微管聚合的抑制剂，在无细胞试验中的 IC50 值为 32 μM。硫酸长春新碱可诱导细胞凋亡。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

微管蛋白抑制剂

名称和识别符

EC号

218-190-0

分子类型

小分子

Isomeric SMILES

CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

关联CAS

57-22-7(free base)

UN Number

1544

Packing Group

分子量

923.04

Beilstein号

3924631