计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 24 篇同行评审文献引用。
概述
无臭，无味。1g溶于190ml水，500ml乙醇，能溶于热水、热醇和稀氢氧化钠溶液，微溶于水和醇，几乎不溶于乙醚。 具有两性性质，可与许多物质生成金属盐和加合物并能保持原有特性。其饱和水溶液（0.6%）呈微酸性（pH=6），在pH=4~9的水溶液中能保持稳定，在碱性溶液中和长时间煮沸时发生分解。饱和水溶液的pH为5.5。
应用
抗菌剂用曼尼希碱的合成
抗肿瘤药舒洛芬类似物的合成
Synthesis of sulofenur analogs for use as antitumor agents.
规格
别名
脲囊素 | 5-尿囊素 | 尿基间二-氮茂烷-2,4-二酮 | 5-脲基海因 | 乙醛酸二酰脲
英文别名
UNII-344S277G0Z | 5-Ureidohydantoin | 5-ureido-Hydantoin | EINECS 202-592-8 | MFCD00005260 | BL Vital | Scar Gel | Allantoin Cream | BL Vital Skin | Scar Care | Glyoxylic(acid) diureide | CCRIS 1958 | Kenaf wet wipe | Sol Mouthwash | (2,5-dioxoimidazolidi
规格或纯度
≥98%
英文名称
Allantoin
生化机理
通过尿酸途径的嘌呤代谢物。尿酸也可与自由基反应生成尿囊素，因此尿囊素可作为氧化应激反应的有效生物标记。
应用
具有两性性质，可与许多物质生成金属盐和加合物并能保持原有特性。其饱和水溶液（0.6%）呈微酸性（pH=6），在pH=4~9的水溶液中能保持稳定，在碱性溶液中和长时间煮沸时发生分解。饱和水溶液的pH为5.5。
储存条件
室温
运输条件
常规运输
纯度
≥98%
名称和识别符
PubChem SID
EC号
202-592-8
分子类型
小分子
IUPAC Name
(2,5-dioxoimidazolidin-4-yl)urea
INCHI
1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11)
InChi Key
POJWUDADGALRAB-UHFFFAOYSA-N
Smiles
C1(C(=O)NC(=O)N1)NC(=O)N
Isomeric SMILES
C1(C(=O)NC(=O)N1)NC(=O)N
分子量
158.12
Beilstein号
102364
Reaxy-Rn
83514
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=83514&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机杂环化合物 |
| 类（Class) | 唑类 |
| 亚类（Subclass） | 咪唑类 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | 咪唑类 |
| 其他上位类（Alternative Parents） | 异脲类 炔丙基型1,3-偶极有机化合物 甲脒类 氮杂环化合物 有机光子化合物 有机氧化合物 亚胺 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 脂肪族杂单环化合物 |
| 取代基（Substituents） | 脂肪族杂单环化合物 - 氮杂环 - 羧酰亚胺 - 羧酰亚胺酸衍生物 - 烃衍生物 - 咪唑 - 亚胺 - 异脲 - 有机1,3-双极性化合物 - 有机硝基化合物 - 有机氧化合物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 丙炔型1,3-双极性有机化合物 |
| 描述（Description） | 该化合物属于咪唑类有机化合物。这类化合物含有咪唑环，即具有两个氮原子位于1位和3位、三个碳原子的芳香五元环。 |
| 外部描述符（External Descriptors） | a small molecule |
三维结构
交互式化学结构模型
关联靶点（人）
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
A498
(42825 活性数据)
ACHN
(49357 活性数据)
CAKI-1
(44928 活性数据)
CCRF-CEM
(65223 活性数据)
COLO 205
(50209 活性数据)
DU-145
(51482 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
K562
(73714 活性数据)
KM12
(47707 活性数据)
M14
(47487 活性数据)
MCF7
(126967 活性数据)
MOLT-4
(49676 活性数据)
OVCAR-3
(48710 活性数据)
OVCAR-4
(44535 活性数据)
OVCAR-5
(45555 活性数据)
OVCAR-8
(47708 活性数据)
PC-3
(62116 活性数据)
RPMI-8226
(44974 活性数据)
RXF 393
(41971 活性数据)
SF-295
(48000 活性数据)
SK-MEL-2
(46422 活性数据)
SK-MEL-28
(48833 活性数据)
SK-MEL-5
(47095 活性数据)
SK-OV-3
(52876 活性数据)
SN12C
(47755 活性数据)
SNB-19
(46794 活性数据)
TK-10
(45540 活性数据)
U-251
(51189 活性数据)
UACC-257
(46019 活性数据)
UACC-62
(47335 活性数据)
UO-31
(46270 活性数据)
786-0
(47912 活性数据)
A549
(127892 活性数据)
NCI/ADR-RES
(33767 活性数据)
T47D
(39041 活性数据)
EKVX
(44102 活性数据)
NCI-H322M
(45589 活性数据)
HCC 2998
(41480 活性数据)
HCT-116
(91556 活性数据)
HOP-92
(41141 活性数据)
Hs-578T
(29457 活性数据)
NCI-H460
(60772 活性数据)
SF-268
(49410 活性数据)
IGROV-1
(47897 活性数据)
LOX IMVI
(44321 活性数据)
HOP-62
(47048 活性数据)
MDA-MB-435
(38290 活性数据)
MDA-N
(28205 活性数据)
关联靶点（其它种属）
Hdac6
Histone deacetylase 6 (222 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Klebsiella pneumoniae (43867 活性数据)
Staphylococcus aureus (210822 活性数据)
Acinetobacter baumannii (41033 活性数据)
Escherichia coli (133304 活性数据)
Plasmodium falciparum (966862 活性数据)
Cryptococcus neoformans (21258 活性数据)
Candida albicans (78123 活性数据)
RAW264.7 (28094 活性数据)
C6 (2371 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
Slightly soluble in water. Freely soluble in alkalis
密度
1.65
敏感性
对湿度敏感
熔点
238-240°C
分子量
158.120 g/mol
XLogP3
-2.200
氢键供体数Hydrogen Bond Donor Count
4
氢键受体数Hydrogen Bond Acceptor Count
3
可旋转键计数Rotatable Bond Count
1
精确质量Exact Mass
158.044 Da
单同位素质量Monoisotopic Mass
158.044 Da
拓扑极表面积Topological Polar Surface Area
113.000 Ų
重原子数Heavy Atom Count
11
形式电荷Formal Charge
0
复杂度Complexity
225.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
1
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H302: 吞食有害
预防措施声明
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P330: 漱口
P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。
P501: 将内容物/容器处理到。。。
WGK Germany
1
RTECS
YT1600000
Merck Index
258
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 H2619111 |
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| H2619108 |
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| J2209034 |
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| D2602168 |
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| D2602169 |
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| D2602170 |
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| D2602171 |
分析证书 | A101660 |
| D2602196 |
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| E2423141 |
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| K2307083 |
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| I2509219 |
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| I2509235 |
分析证书 | A101660 |
| H2511213 |
分析证书 | A101660 |
| H2511212 |
分析证书 | A101660 |
| H2511211 |
分析证书 | A101660 |
| E2325062 |
分析证书 | A101660 |
| K2408183 |
分析证书 | A101660 |
| K2408184 |
分析证书 | A101660 |
| K2408185 |
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| J2209056 |
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| E2423140 |
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| E2423139 |
分析证书 | A101660 |
| C2429003 |
分析证书 | A101660 |
| C2429002 |
分析证书 | A101660 |
| K2307027 |
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| K2307084 |
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| I2111108 |
分析证书 | A101660 |
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分析证书 | A101660 |
| H2109022 |
分析证书 | A101660 |
| L2003096 |
分析证书 | A101660 |
| L2003095 |
分析证书 | A101660 |
| J2209033 |
分析证书 | A101660 |
| J2209040 |
分析证书 | A101660 |
| D2326037 |
分析证书 | A101660 |
| E2310658 |
分析证书 | A101660 |
| E2310652 |
分析证书 | A101660 |
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此产品的引用文献
引用文献
| 1. Qiuzheng Du, Wenjun Guo, Yingying Shi, Ziwei Jing, Zhi Sun. (2023) Boric acid-functionalized lanthanide metal-organic framework used as a ratiometric fluorescence probe for uric acid detection. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2023.109161] |
| 2. Fanxing Xu, Jingxian Wu, Yumei Hu, Chun Chu, Wenjun Liu, Xiang Li, Wen Zheng, Weishuo Yang, Boyan Zhao, Jiangxue Guo, Zhenzhong Wang, Ying Jia, Wei Xiao. (2023) Mechanisms of action underlying the effect of Tongsaimai on wound healing based on experimental and network pharmacology. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37031824] [10.1016/j.jep.2023.116451] |
| 3. Xu Zhang, Xiaotong Wang, Rui Shi, Xiaoku Ran, Xiahong He, Deqiang Dou. (2023) Effective substances and mechanism of red ginseng on rats with spleen-deficiency syndrome based on the substance and energy metabolism as well as the “brain-gut” axis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37003398] [10.1016/j.jep.2023.116438] |
| 4. Gang Wang, Jiali Li, Jing Ji, Lishuang Zhang, Bowen Li, Jiaqi Zhang, Xinya Wang, Wenju Song, Chunfeng Guan. (2023) Combined application of allantoin and strain JIT1 synergistically or additively promotes the growth of rice under 2, 4-DCP stress by enhancing the phosphate solubility, improving soil enzyme activities and photosynthesis. JOURNAL OF PLANT PHYSIOLOGY, [PMID:36739690] [10.1016/j.jplph.2023.153941] |
| 5. Qiqin Wang, Lingjue Sun, Huihui Wu, Ning Deng, Xianglong Zhao, Jingwei Zhou, Tingting Zhang, Hai Han, Zhengjin Jiang. (2022) Rapid fabrication of zwitterionic sulfobetaine vinylimidazole-based monoliths via photoinitiated copolymerization for hydrophilic interaction chromatography. Journal of Pharmaceutical Analysis, [PMID:36320596] [10.1016/j.jpha.2022.05.008] |
| 6. Haojiang Xie, Qiao Bai, Fankai Kong, Yang Li, Xiaoying Zha, Lingqin Zhang, Yiming Zhao, Shasha Gao, Ping Li, Qifeng Jiang. (2022) Allantoin-functionalized silk fibroin/sodium alginate transparent scaffold for cutaneous wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:35358577] [10.1016/j.ijbiomac.2022.03.147] |
| 7. Lingjue Sun, Dongsheng Xu, Yuan Shen, Jacques Crommen, Qiqin Wang, Zhengjin Jiang. (2021) Photo-assisted generation of versatile zwitterionic carboxybetaine-based hypercrosslinked polymers for separation science. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2021.133374] |
| 8. Liu Donghao, Yang Ping, Wang Fangqi, Wang Cong, Chen Li, Ye Sijing, Dramou Pierre, Chen Jianhua, He Hua. (2021) Study on performance of mimic uricase and its application in enzyme-free analysis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (26): (6571-6580). [PMID:34417645] [10.1007/s00216-021-03620-0] |
| 9. Ling Zhou, Kan Hu, Tengguo Dong, Qian Wang, Hengming Huang, Chunhua Lu, Jiahui Kou, Zhongzi Xu. (2021) Carbon ring and molecular scaffold co-doped g-C3N4 heterostructural nanosheets for highly efficient hydrogen evolution. MATERIALS RESEARCH BULLETIN, [10.1016/j.materresbull.2021.111482] |
| 10. Zhou Ling, Sun Menglong, Kou Jiahui, Lu Chunhua, Li Ling, Zhang Fangshu, Xu Zhongzi. (2020) Embedding of stereo molecular scaffold into the planar g-C3N4 nanosheets for efficient photocatalytic hydrogen evolution under ordinary pressure. JOURNAL OF MATERIALS SCIENCE, 56 (2): (1630-1642). [10.1007/s10853-020-05287-x] |
| 11. Xueying Liu, Xiaoku Ran, Muhammad Riaz, Haixue Kuang, Deqiang Dou, Decheng Cai. (2019) Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology. MOLECULES, 24 (12): (2266). [PMID:31216740] [10.3390/molecules24122266] |
| 12. Nan Zhang, Tisong Liang, Quan Jin, Cai Shen, Yifan Zhang, Pu Jing. (2019) Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice. FOOD RESEARCH INTERNATIONAL, [PMID:31229072] [10.1016/j.foodres.2019.04.016] |
| 13. Chen Si, Wang Yating, An Zhihang, Ma Meng, Shi Yanqin, Wang Xu. (2018) Stability, antibacterial ability, and inhibition of “zinc burning” of amitrole as thermal stabilizer for transparent poly(vinyl chloride). JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 137 (2): (437-446). [10.1007/s10973-018-7929-9] |
| 14. Zhong Shengliang, Li Bingmei, Ji Yanhua, Zeng Chenghui. (2016) Multifunctional Coordination Polymer Nanoparticles Based on Allantoin: Single Peak Upconversion Emission, Drug Delivery and Cytotoxicity Study. Journal of Inorganic and Organometallic Polymers and Materials, 26 (3): (527-535). [10.1007/s10904-016-0360-4] |
| 15. Xu Xiaopeng, Chen Si, Wu Bozhen, Ma Meng, Shi Yanqin, Wang Xu. (2014) Effect of allantoin on the stabilization efficiency of Ca–Zn thermal stabilizers for poly(vinyl chloride). JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 119 (1): (597-603). [10.1007/s10973-014-4168-6] |
| 16. Manjila Adhikari, Bianza Moise Bakadia, Li Wang, Ying Li, Zhijun Shi, Guang Yang. (2024) Electricallymodified bacterial cellulose tailored with plant based green materials for infected wound healing applications. Biomaterials Advances, [PMID:39481142] [10.1016/j.bioadv.2024.214087] |
| 17. Yizhan Wang, Yunhui Shi, Jiawei Qiu, JiaBao Cheng, Yao Xu, Yongxin Wang. (2024) Insights into molecular interactions at organic-MBene heterointerfaces for efficient Zn-ion storage. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:39241451] [10.1016/j.jcis.2024.08.247] |
| 18. Yue Kong, Xu Fan, Rongkai Wu, Shibin Nie, Chao Liu, Xiaoyong Liu, Guangyi Zhang, Bihe Yuan. (2024) Multifunctional flame-retardant cotton fabric with hydrophobicity and electrical conductivity for wearable smart textile and self-powered fire-alarm system. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2024.150677] |
| 19. Liang Lai, Mengyao Zhang, Tong Li, Jiahuan Qu, Dongsheng Xu, Pei Yu, Zhengjin Jiang. (2024) Preparation and evaluation of a piperidinium-sulfonate based zwitterionic monolith for HILIC separation. JOURNAL OF CHROMATOGRAPHY A, [PMID:38598890] [10.1016/j.chroma.2024.464864] |
| 20. Qiaoxuan Zhang, Ning Deng, Yingying Dai, Min Zhan, Huihui Wu, Jialin Zeng, Qiqin Wang, Zhengjin Jiang. (2024) Zwitterionic sulfobetaine-based hypercrosslinked hydrophilic materials for bioanalysis. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2024.153018] |
| 21. Qingquan Guo, Yudong Zhang, Chuanjin Tang, Qiuru Li, Fei Liu, Zhenming He, Chenyang Jiang, Jun Xu, Haishan Zhao. (2025) 4-Hydroxyacetophenone is an Antipigmentation Reagent via Inhibiting Tryrosinase Activity. ACS Omega, [PMID:40821508] [10.1021/acsomega.5c03812] |
| 22. Chen Guo, Yixiang Sun, Hongjun Chen, Guangyao Yin, Yizhi Song. (2025) Identification and assessment of Pichia kudriavzevii YS711 isolated from “Jiangshui” with the capacity for uric acid metabolism. MICROBIOLOGICAL RESEARCH, [PMID:40347632] [10.1016/j.micres.2025.128200] |
| 23. Minyi Yuan, Zheng Zhao, Ji Wu, Sumin Bian, Yuling Liao, Ying Zhou, Huikai Shao, Zhengjin Jiang, Qiqin Wang. (2025) Zwitterionic Imidazolium Sulfonate Functionalized Polymeric Monolith for Mixed-Mode HILIC/RPLC Applications. JOURNAL OF CHROMATOGRAPHY A, [PMID:41106254] [10.1016/j.chroma.2025.466462] |
| 24. Ning Hu, Kaikai Zheng, Weiwei Wei, Xiaowen Fang, Yingqing Guo, Xian Xiao, Yuan Zhao. (2026) Distinct root exudation patterns in emergent plants yield similar rhizosphere microbial communities. Journal of Environmental Sciences, [10.1016/j.jes.2026.105642] |
溶液计算器
常见问题
本产品应如何储存？
请于室温条件下保存。
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品如何运输？
本产品按常温标准条件运输，无需温控包装。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 97-59-6，分子式为 C4H6N4O3，分子量为 158.12 g/mol。InChIKey POJWUDADGALRAB-UHFFFAOYSA-N。
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