计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温,充氩。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 57 篇同行评审文献引用。
概述
Building block for an L-piperidinamide catalyst used in an enantioselective Strecker reaction of phosphinoyl imines.
application：
1-Adamantanamine acts as a catalyst in enantioselective strecker reaction of phosphinoyl imines. It is also useful for making adamantane derivatives, i.e. amantadine hydrochloride. It is used in the pharmaceutical industry as antiviral and an antiparkinsonian drug.
规格
别名
1-氨基金刚烷 | 金刚胺
英文别名
Symadine | 1-Adamantamine | Pk-merz | adamantan-1-amine | Adamantanamine | amantadine | Amantidine | Adamantamine | Amantadina | adamantan-1-ylamine | Amantadinum | 1-Aminoadamantane | Aminoadamantane | Adamantylamine
规格或纯度
Moligand™, ≥98%
英文名称
1-Adamantylamine
储存条件
室温,充氩
运输条件
常规运输
作用类型
通道阻滞剂
作用机制
GluN2A 的通道阻断剂;GluN2B 的通道阻断剂;GluN2C 的通道阻断剂;GluN2D 的通道阻断剂
纯度
≥98%
名称和识别符
PubChem SID
EC号
212-201-2
分子类型
小分子
IUPAC Name
adamantan-1-amine
INCHI
1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
InChi Key
DKNWSYNQZKUICI-UHFFFAOYSA-N
Smiles
C1C2CC3CC1CC(C2)(C3)N
Isomeric SMILES
C1C2CC3CC1CC(C2)(C3)N
分子量
151.25
Beilstein号
2204333
Reaxy-Rn
2204333
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2204333&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机氮化合物 |
| 类（Class) | 有机氮化合物 |
| 亚类（Subclass） | 胺类 |
| 中间层级节点（Intermediate Tree Nodes） | 伯胺 |
| 直接上位类(Direct Parent) | 单烷基胺 |
| 其他上位类（Alternative Parents） | 有机光子化合物 碳氢化合物衍生物 |
| 分子骨架（Molecular Framework) | 脂肪族同多环化合物 |
| 取代基（Substituents） | 脂肪族同多环化合物 - 烃衍生物 - 有机氮化合物 - 初级脂肪胺 |
| 描述（Description） | 该化合物属于有机化合物中的单烷基胺类。这类有机化合物含有一个伯级脂肪胺基团。 |
| 外部描述符（External Descriptors） | adamantanes - primary aliphatic amine |
三维结构
交互式化学结构模型
关联靶点（人）
SIGMAR1
Tclin
Sigma 非阿片类细胞内受体 1(Sigma non-opioid intracellular receptor 1)
(1 活性数据)
GRIN2A
Tclin
谷氨酸受体离子型，NMDA 2A(Glutamate receptor ionotropic, NMDA 2A)
(0 活性数据)
GRIN2B
Tclin
谷氨酸受体离子型，NMDA 2B(Glutamate receptor ionotropic, NMDA 2B)
(0 活性数据)
GRIN2C
Tclin
谷氨酸受体离子型，NMDA 2C(Glutamate receptor ionotropic, NMDA 2C)
(1 活性数据)
GRIN2D
Tclin
谷氨酸受体离子型，NMDA 2D(Glutamate receptor ionotropic, NMDA 2D)
(0 活性数据)
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
F2
Tclin
Thrombin
(11687 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
TSHR
Tclin
Thyroid stimulating hormone receptor
(29986 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
MAOB
Tclin
Monoamine oxidase B
(8835 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
AVPR2
Tclin
Vasopressin V2 receptor
(2912 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
AGTR1
Tclin
Type-1 angiotensin II receptor
(5176 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
HTR3A
Tclin
Serotonin 3a (5-HT3a) receptor
(3366 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
GRIN1
Tclin
Glutamate (NMDA) receptor subunit zeta 1
(122 活性数据)
关联靶点（其它种属）
M
Influenza virus A matrix protein M2 (517 活性数据)
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Pde4d
Phosphodiesterase 4D (4 活性数据)
Abcb1b
P-glycoprotein 1 (174 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (103 活性数据)
Saccharomyces cerevisiae (19171 活性数据)
Trypanosoma brucei (78846 活性数据)
Plasmodium falciparum (966862 活性数据)
Leishmania donovani (89745 活性数据)
Trypanosoma cruzi (99888 活性数据)
unidentified influenza virus (265 活性数据)
Influenza B virus (2113 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
Human alphaherpesvirus 1 (11089 活性数据)
Semliki Forest virus (705 活性数据)
Influenza A virus (11224 活性数据)
Enterovirus (1116 活性数据)
Hepatovirus A (249 活性数据)
Trypanosoma brucei rhodesiense (7991 活性数据)
BHK-21 (725 活性数据)
MDCK (10148 活性数据)
Vero (26788 活性数据)
ht1
Hexose transporter 1 (14071 活性数据)
Cynomolgus monkey (4946 活性数据)
H5N1 subtype (135 活性数据)
GCN5
Histone acetyltransferase GCN5 (89 活性数据)
pfk
6-phospho-1-fructokinase (7870 活性数据)
Txnrd1
Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
dengue virus type 2 (2400 活性数据)
H3N2 subtype (329 活性数据)
Respirovirus muris (30 活性数据)
Herpesviridae sp. (115 活性数据)
Brain (1 活性数据)
Plasma (328 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Os06g0676700 protein (12 活性数据)
Grin1
Glutamate NMDA receptor (6467 活性数据)
M
Matrix protein 2 (436 活性数据)
Grin1
Glutamate NMDA receptor; Grin1/Grin2a (798 活性数据)
Influenza A virus H3N2 (588 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
Soluble in organic solvents. Insoluble in water.
敏感性
对空气敏感
熔点
206-208 °C
分子量
151.250 g/mol
XLogP3
2.400
氢键供体数Hydrogen Bond Donor Count
1
氢键受体数Hydrogen Bond Acceptor Count
1
可旋转键计数Rotatable Bond Count
0
精确质量Exact Mass
151.136 Da
单同位素质量Monoisotopic Mass
151.136 Da
拓扑极表面积Topological Polar Surface Area
26.000 Ų
重原子数Heavy Atom Count
11
形式电荷Formal Charge
0
复杂度Complexity
144.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
象形图
信号词
警告
危险声明
H226: 易燃液体和蒸气
H302: 吞食有害
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
H335: 可能引起呼吸道刺激
H412: 对水生生物有害并具有长期持续影响
预防措施声明
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。
P233: 保持容器密闭。
P240: 地面/粘结容器和接收设备
P241: 使用防爆的[电气/通风/照明/.../]设备。
P242: 仅使用无火花的工具。
P243: 采取防静电措施
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P264: 处理后要彻底洗手。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P271: 仅在室外或通风良好的地方使用。
P273: 避免释放到环境中。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P321: 特殊处理（请参阅此标签上的...）。
P330: 漱口
P302+P352: 如皮肤沾染：用水充分清洗。
P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P403+P235: 存放在通风良好的地方。保持低温。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P301+P317: 如果被吞咽：请寻求医疗帮助。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany
3
RTECS
YD1925000
Merck Index
374
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
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分析证书 | A136871 |
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分析证书 | A136871 |
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分析证书 | A136871 |
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分析证书 | A136871 |
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| G2430134 |
分析证书 | A136871 |
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技术文档和文章
Strain Release of Azatricycloalkanes: Modular Bridge-Position Functionalization and Stereochemical Control of Three-Dimensional Bridged Aza Scaffolds
目录： 技术文章
此产品的引用文献
引用文献
| 1. Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu. (2023) Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications. Acta Biomaterialia, [PMID:37482147] [10.1016/j.actbio.2023.07.026] |
| 2. Pengfei Ren, Liuxin Yang, Dandan Wei, Min Liang, Li Xu, Tianzhu Zhang, Wanjun Hu, Zhigang Zhang, Qianli Zhang. (2023) Alginate/polyacrylamide host-guest supramolecular hydrogels with enhanced adhesion. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37196725] [10.1016/j.ijbiomac.2023.124885] |
| 3. Lulu Han, Jiaxin Ji, Chong Zhang, Bingjian Sun, Zhenhua Chao, Hua Zhu, Xiaorong Gao, Jun Ren, Fangling Ji, Liming Ma, Lingyun Jia. (2023) One-Step Assembly of Versatile Multifunctional Coatings Based on Host-Guest and Polyphenol Chemistry. Small, 19 (22): (2206943). [PMID:36755211] [10.1002/smll.202206943] |
| 4. Cheng Gao, Cheryl H. T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang. (2023) Conjugation of Macrophage-Mimetic Microalgae and Liposome for Antitumor Sonodynamic Immunotherapy via Hypoxia Alleviation and Autophagy Inhibition. ACS Nano, [PMID:36739531] [10.1021/acsnano.3c00041] |
| 5. Yuan-Yuan Liu, Jie Liu, Hao Wu, Qiangqiang Zhang, Xue-Rui Tang, Dan Li, Chen-Si Li, Yuanfang Liu, Aoneng Cao, Haifang Wang. (2022) Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells. Nanomaterials, 13 (1): (84). [PMID:36615994] [10.3390/nano13010084] |
| 6. Tianyue Wu, Kefei Zhao, Chenhui Zhang, Tingjun Zhong, Zilu Li, Zhenping Bao, Yuxia Gao, Fengpei Du. (2022) Promising Delivery Platform for Smart Pest Control with High Water-Retaining Capacity. ACS Applied Materials & Interfaces, [PMID:36472305] [10.1021/acsami.2c15737] |
| 7. Tong Sun, Dong Hu, Zhizhang Guo, Hanwen Gong, Qiangwei Xin, Yandong Mu, Jie Weng, Jianshu Li, Xingyu Chen. (2022) Hexapeptide decorated β-cyclodextrin delivery system for targeted therapy of bone infection. JOURNAL OF CONTROLLED RELEASE, [PMID:36462641] [10.1016/j.jconrel.2022.11.047] |
| 8. Wenda Zhu, Yiping Fan, Yanbing Li, Lizhi Peng, Yifang Li, Fengxia Yan, Jiaqiang Zhao, Lei Zhang, Hiroshi Kurihara, Rongrong He, Heru Chen. (2022) Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects. BIOORGANIC CHEMISTRY, [PMID:36356372] [10.1016/j.bioorg.2022.106223] |
| 9. Junqing Shen, Ping Guan, Aiyun Jiang, Wentao Fan, Shengnan Li, Yingliang Liu, Shengang Xu, Shaokui Cao. (2022) A Polyanionic Strategy to Modify the Perovskite Grain Boundary for a Larger Switching Ratio in Flexible Woven Resistive Random-Access Memories. ACS Applied Materials & Interfaces, [PMID:36125291] [10.1021/acsami.2c10562] |
| 10. Jiaxin Zhao, Mingjuan Zhou, Yan Zhou, Danming Chao. (2022) Multi-stimuli-responsive color/fluorescence dual-switching behavior of a hyperbranched polyamidoamine bearing viologen and adamantane units. EUROPEAN POLYMER JOURNAL, [10.1016/j.eurpolymj.2022.111404] |
| 11. Pengfei Ren, Dandan Wei, Min Liang, Li Xu, Tianzhu Zhang, Qianli Zhang. (2022) Alginate/gelatin-based hybrid hydrogels with function of injecting and encapsulating cells in situ. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:35588977] [10.1016/j.ijbiomac.2022.05.058] |
| 12. Q. Wang, X. Yu, Y. Zhao, Y. Wang, K. Chen, Y. Liu, B. Wang, H. Zhang, Y. Sun. (2022) Friction-induced supramolecular nanovalves for the potential treatment of osteoarthritis. Materials Today Chemistry, [10.1016/j.mtchem.2022.100876] |
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