Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity).
CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density
宿主种属
小鼠(Mouse)
特异性
N Cadherin
种属反应性
人(Human)
免疫原
Recombinant protein corresponding to Human N Cadherin
阳性对照
WB: HeLa, HEK293, SH-N-SH and SH-SY5Y whole cell lysates
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
0.5 mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.2
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
图片
N Cadherin Mouse mAb (Ab183886) - Western Blot All lanes: N Cadherin Mouse Antibody (Ab183886) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution Predicted band size: 100 kDa Observed band size: 122 kDa Exposure time: 15.0 s
N Cadherin Mouse mAb (Ab183886) - Western Blot All lanes: N Cadherin Mouse Antibody (Ab183886) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution Predicted band size: 100 kDa Observed band size: 123 kDa Exposure time: 15.0 s
ZJ24F1215186
危险品化学品经营许可证（带存储）