Plays a central role in autophagy.
Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2.
Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis.
May play a role in antiviral host defense12 publications
Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.2 publications
(Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus.
宿主种属
小鼠(Mouse)
特异性
Human Beclin-1
种属反应性
人(Human)
免疫原
Recombinant full length protein corresponding to human Beclin 1
阳性对照
WB: Jurkat and Raji whole cell lysates
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
1.0 mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.4
防腐剂
Myopathy, sarcoplasmic body (MYOSB).
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Beclin 1 Mouse mAb (Ab215027) - Western Blot All lanes: Beclin 1 Mouse mAb (Ab215027) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution
Predicted band size: 52 kDa Observed band size: 56 kDa Exposure time: 60.0 s
ZJ25F0825852
危险品化学品经营许可证（带存储）