Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
宿主种属
人(Human)
特异性
ERBB2/HER2/CD340
种属反应性
人(Human),小鼠(Mouse)
偶联
Unconjugated
作用类型
抑制剂
作用机制
erb-b2 受体酪氨酸激酶 2 抗体
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
CAS编号和信息
180288-69-1
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
10mM PBS, pH6.0.
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
短期储存2-8℃（1-2周）；长期储存-80℃（24个月）；收货后建议分装，避免反复冻融。
图片
Trastuzumab (anti-HER2) (T411999) - Flow Cytometry Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Trastuzumab (anti-HER2) (T411999) - SEC The purity of Trastuzumab (anti-HER2) (T411999) is more than 95% verified by HPLC.
Trastuzumab (anti-HER2) (T411999) - Flow Cytometry Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999) at 1.0 μg/mL for 1 hour at 4°C and detected with Alexa Fluor 488 - conjugated affinipure goat anti - Human IgG. Blue - Human IgG Isotype Control Antibody (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
危险品化学品经营许可证（带存储）