ERBB2 | HER2 | MLN19 | NEU | NGL | Receptor tyrosine-protein kinase erbB-2 | Metastatic lymph node gene 19 protein | MLN 19 | Proto-oncogene Neu | Proto-oncogene c-ErbB-2 | Tyrosine kinase-type cell surface receptor HER2 | p185erbB2 | CD antigen CD340 | V
规格或纯度
无载体,重组,ExactAb™,无叠氮钠,已验证,见COA
生化机理
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
宿主种属
兔(Rabbit)
特异性
ERBB2
种属反应性
人(Human),大鼠(Rat)
免疫原
A synthesized peptide derived from Human ErbB2.
阳性对照
WB: HeLa, 293, A375 lysates; IHC: Rat stomach, Human esophageal carcinoma, Human breast carcinoma tissues; IF/ICC: SKBR cells.