GPCRs, integrins, and receptor tyrosine kinases regulate actin polymerization, contraction, and adhesion turnover through Rho family small GTPases, thereby controlling cell migration, morphology, and tissue function.
The ErbB family pathway is a major module within receptor tyrosine kinase networks. Its key feature is not activation of a single receptor in isolation, but rather the coordinated determination of biological outcomes such as cell proliferation, survival, differentiation, and migration through ...