Necroptosis is a form of regulated cell death centered on the RIPK3–MLKL execution axis. Plasma membrane rupture can be accompanied by the release of DAMPs, tumor antigens, and inflammatory signals, thereby directly linking cell death to changes in the tumor immune microenvironment. ...
“Cold” tumors are generally characterized by insufficient tumor antigen presentation, limited effector T-cell infiltration, and pronounced local immunosuppression, resulting in relatively poor responses to immune checkpoint blockade.