Blockers reduce the functions of ion channels, membrane transporters, or nonspecific molecular interactions and can be used to investigate transmembrane currents, neurotransmitter transport, and interference in immunoassays. Their modes of action include pore blockade, gating modulation, ...
Cell membrane microdomains are jointly organized by specific lipids, scaffold proteins, and the cytoskeleton. They can restrict membrane protein diffusion and regulate ion channels, transporters, receptor signaling, and vesicular trafficking. Abnormalities in membrane microdomain composition ...
The term "IDG families" likely refers to the Illuminating the Druggable Genome (IDG) project, which is a part of the broader NIH Common Fund's effort to explore and better understand the human genome, specifically focusing on the "druggable" portion of the genome.