Interleukin Receptor Signaling: Mechanistic Analysis of the JAK-STAT and NF-κB Axes with an Overview of Assays, Experimental Models, and Translational Boundaries
Interleukins constitute a key group of cytokines produced by immune cells as well as multiple tissue-resident cell types. Their biological effects depend on the assembly of specific receptor complexes and the magnitude of downstream signal transduction, which in turn shapes immune-cell ...
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