CD2-CD58 interactions stabilize contact between immune cells and target cells and participate in the organization of T-cell and NK-cell immune synapses, amplification of activation signals, and maintenance of effector functions. Loss of CD58 or insufficient CD2 signaling can weaken antitumor ...
The TH cell differentiation pathway is one of the most critical regulatory networks in the establishment of adaptive immune responses. Under the combined influence of antigen stimulation, costimulatory signals, and the cytokine microenvironment, naïve CD4+ T cells progressively differentiate ...
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