CD2-CD58 interactions stabilize contact between immune cells and target cells and participate in the organization of T-cell and NK-cell immune synapses, amplification of activation signals, and maintenance of effector functions. Loss of CD58 or insufficient CD2 signaling can weaken antitumor ...
The BAFF pathway and the PD-1 pathway represent two typical directions in immune regulation by therapeutic monoclonal antibodies. The BAFF pathway mainly regulates B-cell survival, maturation, and autoantibody production, making it suitable for studies related to autoimmunity and abnormal ...