Biomedicines
·
2025
·Vol. 13
·期 11
·2584
·
IF 3.9
Ting Cui,Xiaoqing Wang,Qi Wu,Ye Zhong,Fenglou Wang,Yue Zou,Yushu Wang,Shanshan Jiang,Gang Ma
Background/Objectives:Androgenetic alopecia (AGA) is the most common hair loss disorder in dermatological practice. Its primary pathogenesis involves the conversion of testosterone to dihydrotestosterone (DHT) by type II 5α-reductase upon reaching dermal papilla cells (DPCs). DHT impairs DPCs’ activity and inhibits hair growth. Although the FDA-approved drugs finasteride and minoxidil show certain efficacy, they are also associated with severe side effects. This study aims to explore the effects ofTerminalia chebulafruit extract (TCFE) on hair growth and its underlying molecular mechanisms.Methods: We investigated the therapeutic potential of TCFE in hair follicle regeneration, employing a multi-level experimental approach combining in vitro analyses of DPCs, in vivo animal models of AGA, and ex vivo cultures of human hair follicles and scalp tissue.Results: First, RNA-seq analysis and RT-PCR validation revealed that TCFE treatment activated the Wnt and TGF-β3 signaling pathways in DPCs, particularly upregulating the AKR1C gene family, which is involved in DHT metabolism. TCFE also potently inhibited type II 5α-reductase activity and mitigated DHT-induced damage to DPCs. In an AGA mouse model, TCFE reversed the AGA phenotype with efficacy comparable to finasteride. However, unlike finasteride, TCFE specifically enhanced the expression of AKR1C1 and AKR1C3, indicating a distinct mechanism. Finally, in ex vivo organ cultures, TCFE suppressed hair follicle cell apoptosis, promoted proliferation, and thereby stimulated hair growth.Conclusions: These findings suggest that TCFE is a promising natural treatment for AGA, likely acting through multiple mechanisms, including Wnt pathway activation, 5α-reductase inhibition, and enhanced DHT degradation.
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Qianqian Wang,Fang Ma,Ying Xian,Xingyan Shi,Shenglan Ma,Rui Zhang,Hualin Zhang
Introduction: Wound closure, infection prevention and accelerated healing are important to consider in the development of multifunctional dressings. In this study, we aimed to design a dressing that can simulate the structure of normal skin, prevent bacterial infection, improve hemostasis and angiogenesis, accelerate cell adhesion and proliferation, and continuously promote skin regeneration.Methods: We created a multifunctional bilayer dressing coloaded with nanosilver and basic fibroblast growth factor (bFGF) via emulsion electrospinning and vacuum freeze-drying methods. The upper hydrophobic layer was composed of a poly(lactic-co-glycolic acid)/wool keratin (PLGA/WK) electrospun membrane containing nanosilver and bFGF, and the lower hydrophilic layer was composed of a chitosan sponge containing bFGF.Results and Discussion: The bilayer dressing allowed the sustained release of nanosilver and bFGF for more than 2 weeks, had good water absorption and water retention rates, had an appropriate water vapor transmission rate, absorbed excess exudate, and maintained a moist wound environment. In vitro, the dressing prevented bacterial penetration, accelerated fibroblast migration, and promoted angiogenesis and coagulation. Furthermore, the bilayer dressing facilitated cell migration and proliferation, promoted vessel formation, shortened the healing time and significantly promoted wound healing in vivo. By day 3, the wound healing rate in the bilayer dressing group (35.28% ± 2.06%) was significantly higher than that in the control group (23.99% ± 4.32%), representing an increase of approximately 47%. Our findings suggest that this multifunctional bilayer dressing coloaded with nanosilver and bFGF is a potential candidate for skin repair and regeneration applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2025
·Vol. 17
·期 21
·2815
·
IF 4.9
Jia-Yi Qi,Xiao-Feng Hu,Dan Qiu,Ya-Juan Wang,Zhang-Fa Tong
Gelatin microparticles (GMPs) can load functional active substances, but they tend to redissolve in high-temperature aqueous solutions during food processing. In this study, a new loading system adapted to food processing and digestive environments was constructed through the crosslinking of tea polyphenols (TP) on GMPs. The effects of pH, temperature, and crosslinking time on the methylene blue (MB) retention rate in crosslinked gelatin microparticles (cGMPs) were investigated, resulting in optimized crosslinking conditions. Compared with GMPs, the surface of cGMPs was denser and smoother. ATR-FTIR results showed that the N–H groups were involved in the formation of hydrogen bonds during the crosslinking process. The crosslinking effect of TP significantly disrupted the triple-helical structure of gelatin. The melting temperature (Tm) of cGMPs is 147.79 °C, which is significantly higher than that of GMPs (87.11 °C), indicating a marked improvement in thermal stability. In high-temperature aqueous solutions, Folic acid-loaded cGMPs (FA-cGMPs) maintained morphological integrity for 2 h (at 40 °C) and 0.5 h (at 60 °C). In vitro digestion simulations revealed excellent sustained-release characteristics of FA-cGMPs, with a release rate of only 4.91% in simulated gastric fluid and 88.13% in simulated intestinal fluid. This study provides an ideal carrier with food processing stability and intestinal-targeted release capabilities for functional active substances.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Biophysics
·
2025
·Vol. 20
·期 4
·1-16
·
IF 3.2
Zhou Qi,Wang Yangguang,Yuan Gaofeng,Dai Qiuping
Intelligent indicator films were successfully fabricated by incorporating blood peach anthocyanins (BPA) and β-cyclodextrin-encapsulated carvacrol (β-CD@CAR) into chitosan/cellulose nanocrystals (CN) matrices. The prepared films were comprehensively characterized using multiple analytical techniques. The addition of BPA and β-CD@CAR significantly enhanced the films' UV–vis radiation blocking ability, thermal stability, as well as antioxidant (DPPH radical scavenging rate: 45.89% for CN-EO-1A film, vs. 7.71% for pure CN film) and antibacterial activities (inhibition zones of 10.24 mm and 8.52 mm against Escherichia coli and Staphylococcus aureus , respectively). Specifically, β-CD@CAR notably improved the mechanical properties of the films and strengthened their color stability and pH responsiveness. Notably, the CN film with 0.5% (w/w) BPA and β-CD@CAR (CN-EO-0.5A) demonstrated excellent performance, with a tensile strength of 10.99 MPa and an elongation at break of 91.66%. Additionally, it exhibited remarkable color responsiveness to different pH values and ammonia exposure. The effectiveness of the CN-EO-0.5A in monitoring shrimp freshness during storage at 4 °C was further evaluated. The film could visually indicate the freshness levels of shrimp, distinguishing among fresh, sub-fresh, and spoiled states through distinct color changes. Strong correlations were established between the total color difference of the CN-EO-0.5A and key freshness indicators of shrimp, including total volatile basic nitrogen ( R 2 = 0.9630) and total viable count ( R 2 = 0.9983). Therefore, the CN-EO-0.5A film showed promise for real-time monitoring seafood freshness.
✓ 已验证
产品关联
DOI
高影响因子
Chinese Journal of Integrative Medicine
·
2025
·Vol. 31
·期 11
·982-990
·
IF 2.5
Chen Chang-feng,Gao Yin-huan,Fang Qin,Zhou Yong-feng,Liu Yong,Wu Jian,Chen Hao,Wang Lie-cheng,Chen Lei
Objective To elucidate the modulation mechanism of Suanzaoren Decoction (SZRD) on basolateral amygdala (BLA) neuronal activity to alleviate chronic restraint stress (CRS)-related behavioral deficits. Methods The male C57BL/6J mice were assigned to 4 groups using the complete randomization method, including control (CON, n =19), CRS ( n =19), SZRD ( n =21), and fluoxetine (Flu, n =22) groups. Mice were restrained for 6 h per day, over a 21-d period to establish CRS models. The CON group remained in their cages without food or water during the 6-h matching period. SZRD and Flu groups received intragastric administration of SZRD (4.68 g/kg) and Flu (20 mg/kg) daily, respectively, 30 min before restraint for 21 consecutive days. The therapeutic effects of SZRD were evaluated using behavioral tests including the tail suspension test, elevated plus maze test, and forced swimming test. The cellular Fletcher B. Judson murine osteosarcoma proto-oncogene (c-Fos) expression in the BLA was measured using immunofluorescence, while action potential (AP) firing and synaptic transmission in BLA pyramidal neurons were evaluated using whole-cell patch-clamp recordings. Results SZRD administration significantly increased time spent in the open arms and open-arm entries while reducing immobility time ( P <0.05 or P <0.01). It downregulated CRS-induced c-Fos expression and AP firing of pyramidal neurons in the BLA ( P <0.01). Additionally, SZRD selectively attenuated excitatory ( P <0.01), but not inhibitory, synaptic transmission onto BLA pyramidal neurons. Conclusion SZRD alleviated CRS-induced anxiety- and depression-like behaviors in mice by modulating the excitability and synaptic transmission of BLA pyramidal neurons.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2025
·
IF 9.7
Zhao Shikun,Zhang Lurong,Hu Qing,Zhou Yang,Gong Shun,Chen Shangtao,Qin Yawei,Sun Jiangman,Zhao Biao,Pan Kai
Enabling thermoplastic polyamides with significant room temperature phosphorescent (RTP) performance holds great application potential, but remains challenging. Herein, we develop an efficient crystallization-mediated approach to fabricate RTP-active bio-based polyamide 56 (PA56) that simultaneously achieves an exceptional phosphorescence lifetime of 1.214 s and maintains robust mechanical properties with a tensile yield strength exceeding 80 MPa. Comprehensive characterization demonstrates that the material’s RTP characteristics can be precisely tuned through controlled crystallization, where the synergistic effects of electron-rich carbonyl group aggregation (functioning as phosphorescent centers) and interchain hydrogen-bonding networks effectively suppress non-radiative decay pathways. This crystallization-dependent modulation enables systematic optimization of PA56’s phosphorescent properties. Furthermore, we successfully demonstrate practical applications leveraging these unique RTP features, including advanced information encryption/anti-counterfeiting systems and innovative visualization techniques for real-time moisture monitoring and mechanical load assessment in PA56 products. This work establishes a general design strategy for engineering thermoplastic polyamides with tailorable phosphorescence, opening new avenues for smart material development.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Hou Chengmin,Ren Chuangchuang,Bai Yuan
Industrial pigment wastewater poses a serious threat to ecosystems and human health. This study aimed to develop efficient and recyclable adsorbents for the treatment of such wastewater. Initially, a magnetic carrier, W@Fe 3 O 4 , was synthesized by loading Fe 3 O 4 onto wood fibers (W) via co-precipitation. Subsequently, three types of acrylic-modified magnetic wood fiber adsorbents (W@Fe 3 O 4 -g-pGMA, W@Fe 3 O 4 -g-pAA, W@Fe 3 O 4 - g -pHEMA) were fabricated by grafting poly(glycidyl methacrylate) (pGMA), poly(acrylic acid) (pAA), and poly(2-hydroxyethyl methacrylate) (pHEMA), respectively, onto the W@Fe 3 O 4 surface through surface-initiated polymerization. The successful preparation of the materials was confirmed by FTIR, TG, and SEM. Adsorption experiments demonstrated a significant enhancement in the adsorption performance of all three modified materials for Methylene Blue (MB) and Rhodamine B (Rh B). The optimal adsorption conditions were identified as follows: adsorbent dosage of 10 mg, initial MB concentration of 20 mg/L, initial Rh B concentration of 30 mg/L, pH 7, and temperature of 35 °C. Under these optimal conditions, the removal efficiency of MB by W@Fe 3 O 4 - g -pGMA reached 83.47%, with an adsorption capacity of 16.15 mg g −1 , while the removal efficiency of Rh B by W@Fe 3 O 4 - g -pAA reached 90.08%, with an adsorption capacity of 17.95 mg g −1 . The adsorption kinetics were best described by the pseudo-second-order model. Isotherm analysis indicated that the adsorption of MB onto W@Fe 3 O 4 - g -pGMA was better fitted by the Langmuir model, whereas the adsorption of Rh B onto W@Fe 3 O 4 - g -pAA was more consistent with the Temkin model, suggesting a predominantly chemisorption mechanism. After five consecutive adsorption-desorption cycles, the removal rates for MB by W@Fe 3 O 4 - g -pGMA and for Rh B by W@Fe 3 O 4 - g -pAA remained above 70%, indicating excellent recyclability and stability of the materials. This study provides valuable insights for the design of functional adsorbents and their potential application in the advanced treatment of pigment-containing wastewater.
✓ 已验证
产品关联
DOI
高影响因子
Science China-Technological Sciences
·
2025
·Vol. 68
·期 11
·1-10
·
IF 4.9
Guo Jia,Xu Jiaqi,Zhang Xiangwei,Li Zhengmao,Liu Fuyang,He Lei,Long Mingce,Tong Meiping
The rapid aggregation and sedimentation, the high toxicity towards bacteria, and the passivation of surfaces hinder the application of zero-valent iron (ZVI) particles in groundwater remediation. To overcome the shortages, ZVI particles were modified using oxalic acid (an environmental-friendly low-molecular-weight organic acid) together with xanthan gum (a safe and cost-effective high-molecular-weight polymer). We found that ZVI modified with both oxalic acid and xanthan gum exhibited superior Cr(VI) removal performance than those modified solely with oxalic acid and unmodified ZVI. Due to the reduced Fe 2+ release, the toxicity towards Escherichia coli by oxalic acid-xanthan gum modified ZVI was greatly inhibited. Via enhancing electrostatic repulsion through increasing the negative zeta potentials, modification of ZVI by oxalic acid and xanthan gum improved the dispersion of ZVI and reduced their sedimentation in suspension. Moreover, the mobile performance of ZVI in porous media was greatly improved by the modification with oxalic acid and xanthan gum due to the enhanced electrostatic repulsive interaction between ZVI and quartz sand. The observations held true in actual groundwater samples without and with heavy metal contamination. Clearly, the modification of ZVI by using oxalic acid and xanthan gum could be a feasible approach to enhance the practical application potential for the in-situ decontamination of groundwater.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-12
·
IF 5.3
Xiao Wenxiang,Hu Yunqin,Shao Liuwen,Liu Jiannan,Wang Dong,Li Hua
Ultra-stable copper nanoclusters were fabricated for the sensitive determination of cholesterol based on fluorescence turn-off. Red-emitting copper nanoclusters capped with cysteine were first synthesized with a short storage time (15 d). Then, the addition of chitosan and the adjustment of media pH were applied to modulate the unstable clusters into exceptionally stable aggregates with cyan-green emission possessing a long lifetime over 180 days. The aggregation-induced emission (AIE) of chitosan-modified copper nanoclusters (Cys-CuNCs) can be significantly quenched by cholesterol due to the interaction between cholesterol and chitosan. The fluorescence response of Cys-CuNCs to cholesterol exhibits a rapid equilibrium (1 min), high sensitivity with a detection limit of 19.63 μmol·L⁻ 1 (3σ, n = 3), and a wide linear concentration range of 25.0 ~ 1000.0 μmol·L⁻ 1 . The proposed method has good stability and can be employed for cholesterol determination in biofluids. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2025
·
IF 3.3
Lihua Wang,Xionghongcan Zhou,Zengyu Ye,Sha Li,Yayang Wu,Kaiyue Song,Feng Zhao,Xianglong Li
Developing smart nanosystems that integrate controlled drug release with gas therapy represents a promising strategy to enhance chemotherapeutic efficacy while minimizing systemic toxicity. Herein, we report a biodegradable in-situ hydrogen sulfide (H2S) nanogenerator based on ZnS nanoparticles (NPs) for pH-responsive co-delivery of H2S and doxorubicin (DOX). ZnS NPs were synthesized via a rapid hydrothermal method and subsequently functionalized with hyaluronic acid (HA) to form ZnS@HA, which was then electrostatically loaded with DOX to yield ZnS@HA-DOX NPs. The nanosystem maintains structural integrity under physiological conditions (pH 7.4) but selectively releases both DOX and H2S under acidic tumor microenvironment (pH 5.0), as confirmed by fluorescence spectroscopy, lead acetate paper assays, and WSP-1 probe-based quantification. In vitro studies using 4T1 breast cancer cells revealed that ZnS@HA-DOX NPs exhibit significant cytotoxicity compared to ZnS@HA NPs alone, indicating a synergistic effect between H2S gas therapy and chemotherapy. This work demonstrates the potential of ZnS-based nanogenerators as a multifunctional platform for pH-triggered, site-specific, and synergistic cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 11
·1-12
·
IF 2.8
Song Ziyan,Ma Ruolong,Zheng Xiaodan,Zhang Limeng,Ruan Chuanda,Yan Xiaohui,Tian Fei
In this study, Fe 3 O 4 @C@Cu 2 O was synthesized using a solvothermal method. The morphology and structural characteristics of the material were systematically investigated through various characterization techniques, including TEM, XPS, FT-IR, DLS, and VSM. Its antibacterial efficacy was assessed through colony counting. Results showed that at a concentration of 0.5 mg/mL, Fe 3 O 4 @C@Cu 2 O nanoparticles with a copper atomic percentage of 2.42% achieved bactericidal rates of 98.45% against E. coli and 90.58% against S. aureus . Compared to pure Fe 3 O 4 @C and Cu 2 O, the composite material demonstrated a 100% bactericidal rate against E. coli and 99.23% against S. aureus . Notably, after five cycles, the composite nanoparticles maintained effective bactericidal rates, with 82.16% against S. aureus and 94.72% against E. coli . SEM images of bacterial morphology and EPR tests confirmed that the antibacterial mechanism primarily involves the generation of reactive oxygen species(ROS).
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 48
·40478-40490
·
IF 4.6
Qisong Feng,Junjun Ma,Yankun Shen,Zheng Zhou,Shilian Wu,Juan Wang,Junpeng Li,Yu Yang
Flexible printed electronics represent a swift, efficient, and cost-effective technique for depositing metallic conductive materials onto flexible substrates, particularly with the pivotal advancement of functional conductive inks. Metal–organic decomposition conductive inks have garnered substantial interest owing to their straightforward synthesis, convenient storage, and low processing temperatures. However, during low-temperature heating, these inks frequently encounter issues such as fast pyrolysis and gas escape, leading to numerous defects in the microstructure of silver films. Moreover, low silver content results in a high volumetric shrinkage rate, negatively impacting electrical conductivity. To address these limitations, this study synthesized four distinct silver precursors and conducted an in-depth analysis of their chemical compositions, thermal behaviors, and microscopic morphologies. Conductive inks were developed with a high silver content using silver citrate as the silver source with gradient thermal volatilization and low-temperature reduction properties. The impact of solvents and complexing agents on the performance of ink formulations was then examined. Furthermore, the evolution of the inks' microstructure was investigated during thermal decomposition along with the influence of the microscopic morphology on electrical conductivity. Finally, the thermal decomposition mechanism was elucidated in detail. By introducing organic solvents with varying boiling points, the intensity of thermal decomposition was effectively reduced, thereby minimizing the appearance of surface defects such as bubble holes and sintering marks. This strategy significantly enhanced the density of the silver film, reduced its surface roughness, and improved its electrical conductivity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）