G2504365计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
适用于合成 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温,充氩。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 8 篇同行评审文献引用。
概述
N-月桂酰肌氨酸钠盐适用于需要严格控制元素含量的工艺。该产品有助于膜蛋白、糖蛋白的溶解和分离，以及 RNA 和质粒的分离。N-月桂酰肌氨酸钠盐用作消泡补充剂或细菌或其他细胞裂解缓冲液的成分。这表明胶束中间相的顺磁各向异性符号发生了变化。N-月桂酰肌氨酸钠盐对己糖激酶和人类唾液/肠道菌群的抑制率为 0.25%。它在水分散体（1%）中也表现出杀菌活性。N-月桂酰肌氨酸（LS）是一种具有蛋白质变性能力的阴离子表面活性剂，结构类似于月桂酸硫酸钠（SLS）。它在体外能使单纯疱疹病毒（HSV）失去传染性。它也可用作阴道外用制剂中的杀菌剂，以阻止HSV、人类免疫缺陷病毒1型（HIV-1）和其它导致性传播疾病（STD）的病原体的传播。
应用
N-月桂酰肌氨酸钠盐已被用作以下溶液的成分：核酸酶终止混合物，胚胎提取物缓冲液，用于解离染色质中非特异性结合的蛋白质；蛋白酶 K 溶液，用于基因组 DNA 的热变性；10%（w/v）肌氨酰/0.5M 乙二胺四乙酸（EDTA）溶液，用于制备 EDTA 肌氨酰蛋白酶（ESP）缓冲液；杂交缓冲液，用于原位杂交组织化学；胚胎提取缓冲液，用于解离染色质中非特异性结合的蛋白质；蛋白酶K 溶液，用于使酶失活。
The N-lauroylsarcosine sodium salt is applicable for processes that require tight control of elemental content. This product aids in the solubilization and separation of membrane proteins, glycoproteins, and the isolation of RNA and plasmids. N-lauroylsarcosine sodium salt serves as an antifoaming supplement or as a component of a lysing buffer of bacteria or other cells. It indicates the paramagnetic anisotropy sign change in the micelle mesophase. N-lauroylsarcosine sodium salt inhibits hexokinase and the bacterial flora of human saliva/gut at 0.25%. It also exhibits fungistatic activity in aqueous dispersion (1%). N-lauroylsarcosine (LS) is an anionic surfactant with protein denaturant potency that is structurally similar to sodium lauryl sulfate (SLS). It can inactivate herpes simplex virus (HSV) infectivity in vitro. It is used as a microbicide in topical vaginal formulations to block the transmission of HSV, human immunodeficiency virus type 1 (HIV-1), and possibly other pathogens causing sexually transmitted diseases (STDs)
Application
N-Lauroylsarcosine sodium salt has been used as a component:of nuclease stop mix, embryo extract buffer to dissociate nonspecifically bound proteins from chromatin；of proteinase K solution for the heat denaturation of genomic DNA；of 10% (w/v) sarcosyl/0.5 M ethylenediaminetetraacetic acid (EDTA) solution to prepare EDTA-sarcosyl-proteinase (ESP) buffer；in the hybridization buffer for in situ hybridization histochemistry；in the embryo extract buffer to dissociate nonspecifically bound proteins from chromatin；in proteinase K solution to inactivate the enzymes
规格
别名
N-十二烷酰基-N-甲基甘氨酸 钠盐 | 肌氨酰 NL | 月桂酰肌氨酸钠
英文别名
Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester, monohydrochloride | Glycine, N-methyl-N-(1-oxododecyl)-, sodium salt | SODIUM N-LAUROYL SARCOSINATE | N-Lauroylsarcosine, sodium salt | MEDIALAN
规格或纯度
适用于合成
英文名称
N-Lauryl sarcosine sodium salt
储存条件
室温,充氩
运输条件
常规运输
名称和识别符
PubChem SID
EC号
205-281-5
分子类型
小分子
IUPAC Name
sodium;2-[dodecanoyl(methyl)amino]acetate
INCHI
1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1
InChi Key
KSAVQLQVUXSOCR-UHFFFAOYSA-M
Smiles
CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
Isomeric SMILES
CCCCCCCCCCCC(=O)N(C)CC(=O)[O-].[Na+]
分子量
293.39
Beilstein号
5322974
Reaxy-Rn
5322974
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5322974&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机酸及其衍生物 |
| 类（Class) | 羧酸及其衍生物 |
| 亚类（Subclass） | 氨基酸、肽和类似物 |
| 中间层级节点（Intermediate Tree Nodes） | 氨基酸及其衍生物 - α氨基酸及其衍生物 - N-酰基-α氨基酸及其衍生物 |
| 直接上位类(Direct Parent) | N-酰基-α氨基酸 |
| 其他上位类（Alternative Parents） | N-酰胺 叔羧酸酰胺 羧酸盐 一元羧酸及其衍生物 羧酸 有机光子化合物 有机氮化合物 有机两性离子 有机钠盐 有机氧化物 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - 羰基 - 羧酰胺基 - 羧酰胺基 - 羧酸盐 - 烃衍生物 - 单羧酸或其衍生物 - N-酰基-α-氨基酸 - N-酰胺基胺 - 有机碱金属盐 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机盐 - 有机钠盐 - 有机双性离子 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 - 叔羧酸酰胺 |
| 描述（Description） | 该化合物属于有机化合物中的正酰基-α-氨基酸类。这类化合物含有α-氨基酸，其末端氮原子上连接有酰基。 |
| 外部描述符（External Descriptors） | 暂无 |
三维结构
交互式化学结构模型
关联靶点（人）
AR
Tclin
Androgen Receptor
(11781 活性数据)
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
PPARA
Tclin
Peroxisome proliferator-activated receptor alpha
(9197 活性数据)
关联靶点（其它种属）
Ppard
Peroxisome proliferator-activated receptor delta (358 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
密度
1.14g/cm3at 20°C
敏感性
对湿度敏感
闪点(℉)
512.6 °F
闪点(℃)
267 °C
熔点
46°C(lit.)
分子量
293.380 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
0
氢键受体数Hydrogen Bond Acceptor Count
3
可旋转键计数Rotatable Bond Count
12
精确质量Exact Mass
293.197 Da
单同位素质量Monoisotopic Mass
293.197 Da
拓扑极表面积Topological Polar Surface Area
60.400 Ų
重原子数Heavy Atom Count
20
形式电荷Formal Charge
0
复杂度Complexity
260.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
2
安全和危险性（GHS）
信号词
危险
危险声明
H315: 引起皮肤刺激
H318: 造成严重的眼睛损伤
H319: 引起严重眼睛刺激
H330: 吸入致命
预防措施声明
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P284: 如果通风不良，请佩戴呼吸防护装置。
P320: 迫切需要特殊治疗（请参阅此标签上的...）。
P321: 特殊处理（请参阅此标签上的...）。
P302+P352: 如皮肤沾染：用水充分清洗。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P405: 密闭存放
P403+P233: 存放在通风良好的地方。保持容器密闭。
P501: 将内容物/容器处理到。。。
P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。
P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。
P317: 寻求紧急医疗救助。
P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
P316: 立即寻求紧急医疗救助。
WGK Germany
1
RTECS
MC0598960
Merck Index
4368
个人防护装备
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
技术文档和文章
Sodium Lauroyl Sarcosinate: Structure–Property–Application of an Amino-Acid–Based Anionic Surfactant
目录： 技术文章
A Panoramic Guide to Surfactants: Definitions & Mechanisms, Key Metrics, Application Scenarios, and Selection Navigation (Tables 1–3)
目录： 技术文章
A Review of Ten Commonly Used Techniques for Detection, Quantification, and Interaction Analysis in Nucleic Acid Research
目录： 技术文章
dsDNase-Mediated Hydrolysis of Double-Stranded DNA: Enzymatic Characteristics, Methodological Strategies, and Bioanalytical Applications
目录： 技术文章
Potassium Fatty Acid Soaps: Structure and Formulation Applications—Production Processes, Alkalinity, Foam Control, and Low-Foam Cleaning
目录： 技术文章
Why LABSA (Sulfonic Acid) Is Commonly Used in Household Cleaning Formulations: Neutralization Mechanism, Detergency Action, and Formulation Application Points
目录： 技术文章
How Alkyl Polyglucosides (APG) Differ from Cocamidopropyl Betaine (CAPB): Structure, Foam Performance, and Applications in Personal Care and Household-Care Formulations
目录： 技术文章
K12 (Sodium Lauryl Sulfate/SLS) Is More Than a Foaming Agent: Structure, Properties, and Applications in Personal Care and Household Care Formulations
目录： 技术文章
Thickening, Suspension, Auxiliary Stabilization, and Agglomeration Mechanisms of Xanthan Gum in Personal Care Formulations: From Molecular Structure to Processing Applications
目录： 技术文章
Why Can 6501 (Cocamide DEA) Stabilize Foam and Build Viscosity? Structural Mechanism, 1:1/1:1.5 Differences, and Application Selection
目录： 技术文章
Role of Alkyl Glucosides APG in Cleaning Formulations: Structural Features, Core Performance, and Selection Considerations
目录： 技术文章
AES (Fatty Alcohol Polyoxyethylene Ether Sulfate) in Personal and Home-Care Cleansing Formulations: An Analysis of Structure, Performance, and Low-Temperature Flowability
目录： 技术文章
Understanding CAPB from Its Structure: How Cocamidopropyl Betaine Improves Foam, Enhances Mildness, and Supports Thickening
目录： 技术文章
Interfacial Mechanism and Formulation Applications of AEO-9 (Fatty Alcohol Polyoxyethylene Ether): An Analysis of Emulsification, Wetting, Oil Soil Removal, and Co-Formulation Compatibility
目录： 技术文章
Wetting and Penetration Mechanisms of Penetrating Agents in Household and Personal Care Cleaning Systems: Representative Structural Analysis Using JFC, OEP-70, and DOSS as Examples
目录： 技术文章
What Are the Differences Among Sodium Dodecylbenzenesulfonate/SDBS, LAS, and Sodium α-Olefin Sulfonate/AOS: A Comparative Overview of Synthesis, Structure, Mechanism of Action, and Formulation Selection
目录： 技术文章
Analysis of the Foaming Performance Differences Between K12 and AOS: Structure, Acid–Base Stability, and Formulation Selection
目录： 技术文章
Understanding Anionic Surfactants in Household and Personal-Care Formulations from a Structural Perspective: Structural and Performance Differences among Representative Raw Materials such as LAS, AES, K12, AOS, MES, and FMES
目录： 技术文章
Analysis of Amino Acid-Based Surfactants: Basic Structure, Performance Origins, Category Selection, and Applications in Personal Care Formulations
目录： 技术文章
The Structural Logic of Amphoteric Surfactants: Representative Ingredients, Performance Mechanisms, and Formulation Applications in Personal Care and Home Care
目录： 技术文章
此产品的引用文献
引用文献
| 1. Yuying Zhang, Ying Wang, Xuhui Huang, Jie Zheng, Libo Qi, Baoshang Fu, Lei Qin. (2023) Nutritional value of different parts from sea eel (Astroconger myriaster) determined by untargeted-lipidomic approach. FOOD RESEARCH INTERNATIONAL, [PMID:37803738] [10.1016/j.foodres.2023.113402] |
| 2. Siwenjie Qian, Yanju Chen, Cheng Peng, Xiaofu Wang, Hui Wu, Yang Che, Huanying Wang, Junfeng Xu, Jian Wu. (2022) Dipstick-based rapid nucleic acids purification and CRISPR/Cas12a-mediated isothermal amplification for visual detection of African swine fever virus. TALANTA, [PMID:35149424] [10.1016/j.talanta.2022.123294] |
| 3. Mengle Huang, Yanjun Tang, Peng Zhu. (2021) Effect of sodium N-lauroylsarcosinate/hypromellose on the dispersibility and rheological behavior of carbon black for paper coating application. PROGRESS IN ORGANIC COATINGS, [10.1016/j.porgcoat.2021.106514] |
| 4. Yu Luo, Shenyu Huang, Lie Ma. (2021) A novel detergent-based decellularization combined with carbodiimide crosslinking for improving anti-calcification of bioprosthetic heart valve. Biomedical Materials, 16 (4): (045022). [PMID:33979785] [10.1088/1748-605X/ac0088] |
| 5. Yu-Ying Zhang, Yu-Xi Liu, Zheng Zhou, Da-Yong Zhou, Ming Du, Bei-Wei Zhu, Lei Qin. (2019) Improving Lipidomic Coverage Using UPLC-ESI-Q-TOF-MS for Marine Shellfish by Optimizing the Mobile Phase and Resuspension Solvents. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:31293164] [10.1021/acs.jafc.9b01343] |
| 6. Shaoxin Deng, Chengxiang Shi, Xueyan Xu, Hui Zhao, Pingchuan Sun, Tiehong Chen. (2014) Synergy between Polyamine and Anionic Surfactant: A Bioinspired Approach for Ordered Mesoporous Silica. LANGMUIR, [PMID:24571136] [10.1021/la404478b] |
| 7. Liang Wang, Zheng Zhou, Ji Wang, Xu-Song Wang, Da-Yong Zhou, Lei Qin, Xu-Hui Huang. (2024) Mechanism of differentiated and targeted catalysis in complex lipid system under lipase and lipoxygenase mediation. FOOD CHEMISTRY, [PMID:39709915] [10.1016/j.foodchem.2024.142503] |
| 8. Li Zhang, Shanxia Jin, Xiaofeng Guo, Yi Yu, Ping Zhou. (2026) Laser-induced photochemical click reaction enabling on-line tagging and detection of phosphatidylethanolamine by MALDI-mass spectrometry. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2026.116916] |
溶液计算器
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