玻连蛋白 来源于人血浆

CAS: 83380-82-9 货号: np001007
有货
级别和纯度: BioReagent ? 生物试剂级(BioReagent)—— 经测试适用于生命科学和分子生物学。适用于需要生物相容性的细胞培养、检测和生化工作。 天然 ? 天然型(Native)—— 处于天然(非重组、非变性)形态的蛋白/生物分子。当需要天然结构和活性时使用。 PBS Only ? 仅 PBS 配方 —— 以磷酸盐缓冲液供应,不含其他添加剂。当需要不含稳定剂/载体的洁净 PBS 缓冲液时使用。 ≥95%(SDS-PAGE) 见COA
Accession #
P04004
★
规格
库存
价格
数量
25μg
np001007-25μg
现货 Stock Image
¥2,799.90
100μg
np001007-100μg
期货 Stock Image
¥5,699.90
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为什么选择此级别

BioReagent,PBS Only,天然 级 提供 ≥95%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述

玻连蛋白(Vitronectin)与 1 型纤溶酶原激活物抑制剂(Plasminogen Activator Inhibitor Type 1,PAI-1)是两种在循环系统和细胞周围区域相互作用的蛋白质,可调控纤溶作用、细胞黏附与迁移过程。其中,1 型纤溶酶原激活物抑制剂属于丝氨酸蛋白酶,它通过与血浆蛋白玻连蛋白结合,影响止血过程的关键调控环节,例如血栓形成与伤口愈合。此外,在肿瘤转移等生理病理过程中,玻连蛋白与 1 型纤溶酶原激活物抑制剂形成的复合物还能调控血小板及细胞与细胞外基质的结合。血浆中玻连蛋白的浓度为 200-400 μg/ml。
本产品由特定血浆制备而成,该血浆经美国食品药品监督管理局(FDA)要求的检测证实,乙型肝炎表面抗原(HBsAg)、丙型肝炎抗体(anti-HCV)、乙型肝炎核心抗体(anti-HBc)检测结果均为阴性,1 型和 2 型人类免疫缺陷病毒抗体(anti-HIV 1 & 2)检测结果也为阴性。
阿拉丁(Aladdin)产品均为实验室试剂,不得用于人体给药,也不得用于任何药物相关用途。仅限科研或进一步生产使用。

 Vitronectin and plasminogen activator inhibitor type 1 are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration. Plasminogen activator inhibitor type 1, a serine proteinase, through its binding to the plasma protein vitronectin, influences processes that are key regulators of hemostatic process, for example, thrombosis and wound healing. In addition the vitronectin and plasminogen activator inhibitor type 1 complex regulates binding of blood platelets and cells to extracellular substrata in events like tumor metastasis. The plasma concentration of vitronectin is 200 to 400 μg/ml.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

规格

产品名称
玻连蛋白 来源于人血浆
别名
玻连蛋白,人血浆 | 天然人玻连蛋白/S蛋白
英文别名
Complement S Protein | Epibolin | S Protein | S-protein | Serum Spreading Factor | Serum-spreading factor | Somatomedin B | Somatomedin-B | V75 | Vitronectin | Vitronectin V10 subunit | Vitronectin V65 subunit | VN | VNT | VTN | VTNC_HUMAN
规格或纯度
BioReagent,天然,PBS Only,≥95%(SDS-PAGE),见COA
生化机理
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. Post-translational: Sulfated on tyrosine residues. N- and O-glycosylated. Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.Phosphorylation sites are present in the extracellular medium.
种属
人(Human)
Accession #
来源
天然
预测分子量
65 kDa, 75 kDa
CAS编号和信息
83380-82-9
分子类型
蛋白质
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10 mM sodium phosphate, pH 7.7
浓度
见COA
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃(>1年);复溶后建议分装,避免反复冻融。

技术文档

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找到2个结果

批号(Lot Number) 证书类型 货号
ZJ26F0333364 分析证书 np001007
ZJ26F0333363 分析证书 np001007
技术文档和文章
纯净提取,智慧溶剂:天然提取试剂实践手册
Clean Extracts, Smart Solvents: The Natural Extraction Reagent Playbook
RGD分子影像:给肺癌“做血管体检”的新工具 —基于整合素αvβ3的成像策略及阿拉丁相关RGD肽、抗体与连接子推荐
RGD-Based Molecular Imaging: A New Tool for “Vascular Check-ups” in Lung Cancer — Imaging Strategies Targeting Integrin αvβ3 and Recommended Aladdin RGD Peptides, Antibodies and Linkers
常用细胞培养包被液的选型逻辑、操作参数与应用边界
Selection Logic, Operating Parameters, and Application Boundaries of Common Cell Culture Coating Solutions
细胞培养包被体系中玻连蛋白、层粘连蛋白与纤连蛋白的适用性比较
Applicability Comparison of Vitronectin, Laminin and Fibronectin in Cell Culture Coating Systems
细胞培养包被体系中玻连蛋白、层粘连蛋白与纤连蛋白的适用性比较
Applicability Comparison of Vitronectin, Laminin and Fibronectin in Cell Culture Coating Systems
人体主要器官类器官的培养体系、分子标志物与研究应用
Culture Systems, Molecular Markers, and Research Applications of Major Human Organ Organoids
纤连蛋白的结构与功能:细胞黏附、皮肤创伤修复与外用应用
Structure and Functions of Fibronectin: Cell Adhesion, Cutaneous Wound Repair, and Topical Applications
环化如何改变多肽行为:以Cyclopeptide-5为例解析构象预组织、皮肤递送与整合素结合
How Cyclization Changes Peptide Behavior: Conformational Preorganization, Skin Delivery, and Integrin Binding, Using Cyclopeptide-5 as an Example
从贴壁困难到稳定培养:细胞附着因子的选择与应用
From Difficult Attachment to Stable Culture: Selection and Application of Cell Adhesion Factors
含小胶质细胞脑类器官的构建、表征与神经疾病建模
Construction, Characterization, and Neurological Disease Modeling of Microglia-Containing Brain Organoids
穿膜肽、靶向肽与自组装肽:作用机制与功能应用
Cell-Penetrating, Targeting, and Self-Assembling Peptides: Mechanisms and Functional Applications
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