转铁蛋白来源于食蟹猴血浆

Name: 转铁蛋白 来源于食蟹猴血浆
SKU: np001012
Availability: InStock

CAS: 11096-37-0 货号: np001012

19篇引用文献 COA

有货

级别和纯度: 天然 ? 纳米粉末 ? PBS Only ? ≥95%(SDS-PAGE) 冻干前蛋白浓度见COA

Accession #

A0A2K5UXZ0

规格

库存

价格

数量

50μg

np001012-50μg

期货

¥1,199.90

250μg

np001012-250μg

期货

¥3,399.90

1mg

np001012-1mg

期货

¥8,399.90

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概述规格储存与运输技术文档高级数据产品属性质检证书（CoA,COO,BSE/TSE 和分析图谱) 此产品的引用文献技术文档和文章溶液计算器

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为什么选择此级别

PBS Only,天然,纳米粉末级提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 19 篇同行评审文献引用。

概述

转铁蛋白是血浆中主要的铁转运蛋白，可结合两个三价铁离子，介导铁从吸收部位向全身各组织转运。

蛋白生物学功能

转铁蛋白是一种多功能单体糖蛋白，主要在肝脏合成，大量存在于血浆中，在铁代谢与铁稳态调节中发挥核心作用。每个转铁蛋白分子可高亲和力可逆结合 2 个三价铁离子（Fe³⁺），安全且可控地将铁从肠道吸收位点和巨噬细胞转运至全身组织，尤其输送至骨髓用于血红蛋白合成。该铁转运过程依靠细胞表面的转铁蛋白受体介导，通过受体介导的胞吞作用实现细胞精准摄铁。

除铁转运功能外，转铁蛋白还具备显著抗菌活性：通过螯合游离铁，减少细菌、真菌可利用的铁源，属于机体固有免疫防御机制，能够抑制细菌与真菌增殖（抑菌作用）。

临床层面，转铁蛋白水平变化与多种病症相关：缺铁性贫血、妊娠状态下转铁蛋白水平升高；炎症疾病、肾病综合征、低蛋白血症以及无转铁蛋白血症这类罕见遗传病会导致其水平下降，无转铁蛋白血症可引发严重贫血与组织铁过载。

转铁蛋白的应用涵盖临床诊断：作为铁营养状态及部分代谢疾病的生物标志物；生物技术领域，是细胞培养基中保障细胞良好生长的必需添加组分。此外，转铁蛋白及其受体还被研究用于靶向药物递送载体，尤其在穿透血脑屏障、治疗中枢神经系统疾病方向有应用潜力。

Transferrin is the primary plasma iron transporter, bound to two ferric ions, which facilitates the distribution of iron from absorption sites to tissues throughout the body.

Role of protein in biology

Transferrin is a multifunctional monomeric glycoprotein primarily synthesized in the liver and found abundantly in plasma, where it plays a central role in iron metabolism and homeostasis. Each transferrin molecule can reversibly bind two ferric (Fe³⁺) ions with high affinity, facilitating the safe transport and regulated distribution of iron from absorption sites in the gut and macrophages to tissues throughout the body, especially to the bone marrow for hemoglobin synthesis. This iron delivery is mediated through transferrin receptors on cell surfaces, enabling receptor-mediated endocytosis and precise cellular iron uptake.

Beyond iron transport, transferrin possesses significant antimicrobial properties by sequestering free iron, thereby limiting its availability to bacteria and fungi-a process that contributes to innate immune defense and exhibits bacteriostatic and fungistatic effects. Clinically, altered transferrin levels are linked to various conditions: increases are seen in iron-deficiency anemia and pregnancy, while decreases occur in inflammatory diseases, nephrotic syndrome, hypoproteinemia, and rare genetic disorders like atransferrinemia, which causes severe anemia and iron overload in tissues.

Transferrin’s applications extend to clinical diagnostics, where it serves as a biomarker for iron status and certain metabolic disorders, and to biotechnology, where it is an essential supplement in cell culture media for optimal cell growth. Additionally, transferrin and its receptor are being explored as targeted drug delivery vehicles, particularly for crossing the blood-brain barrier and treating central nervous system diseases.

规格

产品名称

转铁蛋白来源于食蟹猴血浆

规格或纯度

天然, 纳米粉末, PBS Only, ≥95%(SDS-PAGE), 冻干前蛋白浓度见COA

生化机理

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

种属

食蟹猴(Cynomolgus monkey)

来源

天然

预测分子量

80 kDa

CAS编号和信息

11096-37-0

分子类型

蛋白质

产品线

生物产品