Omeprazole is a benzimidazole derivative, a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH.

用途

Omeprazole has been used as an atypical cytochrome P450 (CYP) 1A2 inducer in Dulbecco′s modified eagle′s medium (serum free) to study the effects of inducers on CYP activities in human hepatocytes and also to compare with other classical aryl hydrocarbon receptor ligands.

Information

Omeprazole Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase , used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.
In vitro

Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect.

In vivo

Cell Data

cell lines：HOS, HTB-186 Daoy, TC-71, RD, SK-N-AS, SK-N-DZ, LD and KCNR cells

Concentrations：

Incubation Time：

Powder Purity:≥95%

规格

英文别名

6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Omeprazole

生化机理

奥美拉唑是一种质子泵抑制剂，可阻断 H(+)-K(+)-ATP 酶，用于治疗消化不良、消化性溃疡病、胃食管反流病、喉咽反流和卓-艾综合征。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

ATP4A 抑制剂；ClC-2 激活剂

名称和识别符

分子类型

小分子

Isomeric SMILES

CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC

分子量

345.42

Reaxy-Rn

6489199

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6489199&ln=

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高级数据

关联靶点（人）

ATP4A Tclin 钾转运 ATPase α 链 1(Potassium-transporting ATPase alpha chain 1) (0 活性数据)

点击查看靶蛋白信息： ATP4A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CLCN2 Tclin 氯离子通道蛋白2(Chloride channel protein 2) (0 活性数据)

点击查看靶蛋白信息： CLCN2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

熔点

158-159°C

安全和危险性（GHS）

WGK Germany

RTECS

DD9087000

Merck Index

6845

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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H2617603	分析证书	O407783

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