胰岛素样生长因子-1（IGF-1）是一种分子量为7.6kD的激素，其分子结构与胰岛素类似。IGF-1的主要作用机理是通过与其特异性受体（IGF1R）结合来诱导细胞内的信号传导。IGF-1是AKT信号通路的最有效的激活因子之一，激活AKT信号通路后，刺激细胞生长及增殖，并抑制细胞凋亡。IGF-1 LR3在完整的IGF-1分子的N端添加了13个氨基酸形成83个氨基酸的长链IGF-1，并将IGF-1分子的第3个氨基酸谷氨酸（E）用精氨酸（R）取代，所以称为R3。IGF-1 LR3与未作修饰的IGF-1相比，具有更高的稳定性和生物活性。
规格参数
来源 大肠杆菌
外观 白色冻干粉
活性 ≥1.0×106IU/mg
pH值 6.5-7.5
分子量 7.6kD
内毒素 <5EU/mg
CAS No 946870-92-4
注意事项
复溶：建议用无菌水重溶rIGF-1 LR3冻干粉至100-200 ug/ml，可用其他溶剂进行进一步稀释。溶解后的rIGF-1 LR3 4℃可保存2-7天，尽快用完。若短期不用，请置于-20℃保存。开启后，请尽快使用，避免污染。
使用限制
仅适于科研、实验室和生产使用，不能直接使用于人体
Product Introduction
Insulin like growth factor-1 (IGF-1) is a hormone with a molecular weight of 7.6kd, and its molecular structure is similar to that of insulin.The main mechanism of action of IGF-1 is to induce signaling within the cell by binding to its specific receptor (IGF1R).IGF-1 is one of the most potent activators of the Akt signaling pathway, which, upon activation, stimulates cell growth and proliferation, and inhibits apoptosis.IGF-1 LR3 adds 13 amino acids to the N-terminus of the intact IGF-1 molecule to form 83 amino acid long-chain IGF-1 and replaces the 3rd amino acid of IGF-1 molecule, glutamic acid (E), with arginine (R), so called R3.IGF-1 LR3 has higher stability and bioactivity than IGF-1 without modification.
Specification parameters
Source Escherichia coli
Appearance white lyophilized powder
Activity ≥1.0×106IU/mg
pH 6.5-7.5
Molecular weight 7.6kD
Endotoxin <5EU/mg
CAS No 946870-92-4
Matters needing attention
Reconstitution: it is recommended to reconstitute the rigf-1 LR3 lyophilized powder to 100-200 UG / ml with sterile water and further dilution with other solvents may be performed.Rigf-1 LR3 dissolved at 4 ° C can be stored for 2-7 days and used up as soon as possible.To not use for short periods, store at - 20 ℃.Use as soon as possible after opening to avoid contamination.
Limitations of use
It is suitable for research, laboratory and production use only and cannot be used directly in humans
C2308051
危险品化学品经营许可证（带存储）