计算溶液所需的质量、体积或浓度。
Recombinant Human GM-CSF Protein (rp146523)-Protein Bioactivity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <0.2ng/mL.
ActiBioPure™,PBS Only,无动物源,无叠氮钠,无载体,生物活性,高性能 级 提供 ≥98%(SDS-PAGE&HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
人粒细胞-巨噬细胞集落刺激因子(GM-CSF)由多种不同类型的细胞(包括活化的T细胞、B细胞、巨噬细胞、肥大细胞、内皮细胞和成纤维细胞)在细胞因子或免疫和炎症刺激下分泌。它最初被认为是一种生长因子,可以支持粒细胞-巨噬细胞祖细胞的体外集落形成,并具有刺激各种造血前体细胞生长和分化的功能。GM-CSF也有报道在非造血细胞上有功能作用,可以诱导人内皮细胞迁移和增殖。此外,它可以刺激多种肿瘤细胞系的增殖,包括骨原性肉瘤、癌和腺癌细胞系。GM-CSF被用作一种药物,在化疗后刺激白细胞的产生,最近也在临床试验中评估了它作为hiv感染患者疫苗佐剂的潜力。重组人GM-CSF是非糖基化多肽链,包含127个氨基酸。
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Human Granulocyte-Macrophage Colony Stimulating Factor Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is secreted by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimulation. It was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors and has functions of stimulates the growth and differentiation of hematopoietic precursor cells from various lineages. GM-CSF has also been reported to have a functional role on non-hematopoietic cells and can induce human endothelial cells to migrate and proliferate. Additionally, it can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. GM-CSF is used as a medication to stimulate the production of white blood cells following chemotherapy and has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The recombinant Human GM-CSF is a non-glycosylated polypeptide chain containing 127 amino acids.
Recombinant Human GM-CSF Protein (rp146523)-Protein Bioactivity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <0.2ng/mL.
Recombinant Human GM-CSF Protein (rp146523)-SDS-PAGE
3μg/lane of Recombinant Human GM-CSF Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a single band at 13.7 kDa.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 | |
| 分析证书 | rp146523 |
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